A5049839849- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Antimicrobial Resistance in Staphylococcus
- Bone Tissue Engineering Materials
- Infective Endocarditis Diagnosis and Management
- Dental materials and restorations
- Diet and metabolism studies
- Viral Infections and Immunology Research
- Intraocular Surgery and Lenses
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Glaucoma and retinal disorders
- Additive Manufacturing and 3D Printing Technologies
- Total Knee Arthroplasty Outcomes
- Cerebrospinal fluid and hydrocephalus
- 3D Printing in Biomedical Research
- Bone fractures and treatments
- Pelvic and Acetabular Injuries
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Hip disorders and treatments
- Infectious Diseases and Tuberculosis
- Liver Disease and Transplantation
- Calcium Carbonate Crystallization and Inhibition
United States Army Institute of Surgical Research
2020
University of Rochester
2015-2019
University of Rochester Medical Center
2018-2019
University of Milan
2003
Although Staphylococcus aureus osteomyelitis is considered to be incurable, the major bacterial reservoir in live cortical bone has remained unknown. In addition biofilm bacteria on necrotic tissue and implants, studies have implicated intracellular infection of osteoblasts osteocytes as a mechanism chronic osteomyelitis. Thus, we performed first systematic transmission electron microscopy (TEM) formally define reservoirs S. chronically infected mouse (Balb/c J) long tissue. rare, evidence...
Abstract Biphasic calcium phosphate scaffolds formed via three dimensional (3D) printing technology to exhibit porosity and chemical resorbability promote osseointegration often lack the strength toughness required withstand loading in bone tissue engineering applications. Herein, sintering CaP:poly(caprolactone) (PCL) composite formation were explored improve 3D printed scaffold toughness. Hydroxyapatite α‐tricalcium (α‐TCP) biphasic powders using phosphoric acid binder, which generated...
Drug repurposing offers an expedited and economical route to develop new clinical therapeutics in comparison traditional drug development. Growth-based high-throughput screening is concomitant with enables rapid identification of therapeutic uses for investigated drugs; however, this method not compatible microorganisms abnormal growth patterns such as Staphylococcus aureus small-colony variants (SCV). SCV subpopulations are auxotrophic key compounds biosynthetic pathways, which result low...
Osteomyelitis is a chronic bone infection that often treated with adjuvant antibiotic-impregnated poly(methyl methacrylate) (PMMA) cement spacers in multi-staged revisions. However, failure rates remain substantial due to recurrence of infection, which attributed the poor performance PMMA as drug release device. Hence, objective this study was design and evaluate bioresorbable calcium phosphate scaffold (CaPS) for sustained antimicrobial investigate its efficacy murine model femoral...
Femoroacetabular impingement (FAI) represents complex alterations in the bony morphology of proximal femur and acetabulum. Imaging studies have become crucial diagnosis treatment planning for symptomatic FAI but also limited patient understanding satisfaction. Exploration alternative counseling modalities holds promise improved understanding, satisfaction, ultimately outcomes.To compare perceived functional anatomy pathomorphology among patients counseled with routine computed tomography...
Abstract Background Chronic wound infections continue to plague the U.S. healthcare system, especially in trauma scenarios. Multidrug resistance and capacity form biofilm enables pathogens survive clinical regimens of antibiotics prompting need find antibiotic alternatives. In past years, cholesterol lowering class drugs, statins, were identified have antibacterial effects on responsible for various infections. The objective this study was screen all available statins against a panel ( S....