A5036809264- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Bone Metabolism and Diseases
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Connective tissue disorders research
- Hedgehog Signaling Pathway Studies
- Computational Drug Discovery Methods
- Craniofacial Disorders and Treatments
- Natural Antidiabetic Agents Studies
- Melanoma and MAPK Pathways
- Kruppel-like factors research
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- Bioactive natural compounds
- Immune responses and vaccinations
- Zebrafish Biomedical Research Applications
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Hematopoietic Stem Cell Transplantation
- Phytochemicals and Antioxidant Activities
Cornell University
2017-2023
Weill Cornell Medicine
2018-2023
Cedars-Sinai Medical Center
2022-2023
University of California, Los Angeles
2022-2023
Institute of Science and Technology
2012
Diabetes mellitus is a metabolic disorder caused due to insulin deficiency.Banana flower rich source of flavonoids that exhibit anti diabetic activity.Insulin receptor tetramer belongs family tyrosine kinases.It contains two alpha subunits form the extracellular domain and beta constitute intracellular kinase domain.Insulin binds region causes conformational changes lead activation kinase.This leads autophosphorylation, step crucial in signaling pathway.Hence, compounds augment activity...
The c-Jun N-terminal kinases (JNKs) are ancient and evolutionarily conserved regulators of proliferation, differentiation, cell death responses. Currently, in vitro studies offer conflicting data about whether the JNK pathway augments or represses osteoblast contribution to regulation bone mass vivo remains unclear. Here we show that Jnk1-/- mice display severe osteopenia due impaired formation, whereas Jnk2-/- a mild only evident long bones. In order both confirm these effects were...
Abstract The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict their nomination of osteoblasts versus osteoclasts the key producers skeletal and additionally offer conflicting data on effects osteoclastogenesis. Here, aiming to address this discrepancy, we found no observable expression during human or mouse osteoclastogenesis only modest SLIT3-mediated osteoclast differentiation. Conditional deletion cathepsin K...
Hedgehog signaling is essential for bone formation, including functioning as a means the growth plate to drive skeletal mineralization. However, mechanisms regulating hedgehog specifically in bone-forming osteoblasts are largely unknown. Here, we identified SLIT and NTRK-like protein-5(Slitrk5), transmembrane protein with few functions, negative regulator of osteoblasts. Slitrk5 selectively expressed loss enhanced osteoblast differentiation vitro vivo. Loss SLITRK5 leads increased...
Objective We aimed to investigate the hypothesis that interferon (IFN)–stimulated gene (ISG) expression in systemic lupus erythematosus (SLE) monocytes is linked changes metabolic reprogramming and epigenetic regulation of ISG expression. Methods Monocytes from healthy volunteers patients with SLE at baseline or following IFNα treatment were analyzed by extracellular flux analysis, proteomics, metabolomics, chromatin immunoprecipitation, The histone demethylases KDM6A/B inhibited using...
In brief: A newly discovered periosteal stem cell pool with features distinct from other skeletal mesenchymal cells (MSCs) is present in murine and human bone reveals a pivotal function intramembranous ossification, cortical architecture fracture healing conditional knockout mouse strains.
Rauwolfia serpentina also known as Sarpagandha is an integral part of Ayurvedic medical system for over centuries the treatment various ailments.The leaves and roots contain alkaloids which are secondary metabolites.Major identified Reserpine, Rauwolfine, Serpentine, Sarpagine, Ajmaline, Yohimbine Ajmalicine.Insulin binds to insulin receptors that present on different cells body.Insulin mediates absorption glucose into cell.Insulin receptor belongs class tyrosine kinase receptor.The three...
Vertebral bone is subject to a distinct set of disease processes from those long bones, notably including much higher rate solid tumor metastases that cannot be explained by passive blood flow distribution alone. The basis for this biology vertebral has remained elusive. Here we identify skeletal stem cell (vSSC), co-expressing the transcription factors ZIC1 and PAX1 together with additional surface markers, whose expression profile function are markedly cells (lbSSCs). vSSCs display formal...
Most skeletal fragility disorders are characterized by bone loss with a concurrent gain in marrow adipocytes 1-8. This suggests that cell forms at the expense of osteoblasts is central to pathogenesis disorders. However, this cellular point bifurcation between adipocyte and osteoblast differentiation pathways remains unknown. Here, we identify new type defined co-expression stem precursor markers, 9-13 (CD24+CD29+ cells (SSCs)), serves as key pathways, giving rise closely related...
Abstract Craniosynostosis is a group of disorders premature calvarial sutural fusion. An incomplete understanding the stem cells (CSCs) that produce fusion-driving osteoblasts has limited development non-surgical therapeutic approaches for craniosynostosis. Here we show both physiologic mineralization and pathologic fusion in craniosynostosis reflect interaction two separate cell lineages; recently reported CathepsinK (CTSK) lineage CSC (CTSK+ CSC)1 Discoidin domain-containing receptor 2...
<h3></h3> The authors have declared that no conflict of interest exists. <h3>Objective</h3> To investigate the hypothesis interferon (IFN) stimulated gene (ISG) expression in systemic lupus erythematosus (SLE) monocytes is linked to changes metabolic reprogramming and epigenetic regulation ISG expression. <h3>Methods</h3> Monocytes from healthy volunteers SLE patients at baseline or following IFNα treatment were analyzed by extracellular flux analysis, proteomics, metabolomics, chromatin...