A5066721131- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Anesthesia and Neurotoxicity Research
- COVID-19 and healthcare impacts
- S100 Proteins and Annexins
- Hip disorders and treatments
- Bacteriophages and microbial interactions
- Congenital Heart Disease Studies
- Artificial Intelligence in Healthcare and Education
- Rabies epidemiology and control
- Bone health and treatments
- Bone fractures and treatments
- Cellular Mechanics and Interactions
- Chemokine receptors and signaling
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Muscle Physiology and Disorders
- Tracheal and airway disorders
- Bioinformatics and Genomic Networks
- Molecular Biology Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Cardiac, Anesthesia and Surgical Outcomes
Hospital for Special Surgery
2020-2025
New York Hospital Queens
2021
NewYork–Presbyterian Hospital
2021
Cornell University
2021
Brigham and Women's Hospital
2020
Harvard University
2020
Massachusetts General Hospital
2017-2018
Sun Yat-sen University
2018
The First Affiliated Hospital, Sun Yat-sen University
2018
Large language model (LLM) chatbots possess a remarkable capacity to synthesize complex information into concise, digestible summaries across wide range of orthopedic subject matter. As LLM become widely available they will serve as powerful, accessible resource that patients, clinicians, and researchers may reference obtain about science clinical management. Here, we examined the performance three well-known easily chatbots-ChatGPT, Bard, Bing AI-in responding inquiries relating management...
Abstract Transformer-based large language models (LLMs) have demonstrated significant potential in the biological and medical fields due to their ability effectively learn from large-scale, diverse datasets perform a wide range of downstream tasks. However, LLMs are limited by issues such as information processing inaccuracies data confabulation, which hinder utility for literature searches other tasks requiring accurate comprehensive extraction extensive scientific literature. In this...
Abstract Administration of bisphosphonates following total joint arthroplasty might be beneficial to reduce aseptic loosening. However, their effects on peri‐implant bone formation and bone–implant interface strength have not been investigated yet. We used a physiologically loaded mouse implant model investigate the short‐term postoperative systemic alendronate osseointegration. A titanium with rough surface was inserted in proximal tibiae 17‐week‐old female C57BL/6 mice ( n = 44)....
ABSTRACT The number of total joint replacements (TJRs) in the United States is increasing annually. Cementless implants are intended to improve upon traditional cemented by allowing bone growth directly on surface implant longevity. One major complication TJR loosening, which related deficient osseointegration cementless TJRs. Although poor aged patients typically attributed decreased basal mass, little known about molecular pathways that compromise onto porous titanium implants. To identify...
The current murine models of peri-implant osseointegration failure are associated with wear particles. However, the clinical is not Here, we develop a model particles and validate it by comparing cellular composition interfacial tissues human samples collected during total joint arthroplasty revision for aseptic loosening.
To delineate differences in short-term complications between outpatient versus inpatient open reduction and internal fixation (ORIF) of proximal humerus fractures.Retrospective database review.Hospitals participating the American College Surgeons National Surgical Quality Improvement Program database.Patients with fractures from 2005 to 2017.Proximal fracture ORIF.Thirty-day readmission, reoperation, thromboembolic events, other complications.In total, 920 2490 ORIF cases were identified....
An in vivo animal model of a weight-bearing intra-articular implant is crucial to the study osseointegration and aseptic loosening caused by failure. Osseointegration, defined as direct structural functional attachment between living bone tissue surface load-carrying implant, essential for stability considered prerequisite long-term clinical success implants total joint arthroplasty. Compared large models, murine models offer extensive genetic tools tracing cell differentiation...
Despite the success of standard antiseptic irrigation solutions in reducing periprosthetic joint infection (PJI) rates, there is still a need for more effective solutions. Synergistic use povidone-iodine (PI) and hydrogen peroxide (H
Background: Active recruitment of osteogenic cells by secreted signaling factors, such as stromal-cell-derived factor 1 (SDF-1), has recently been proposed a novel strategy to enhance osseointegration. However, the intrinsic importance SDF-1/C-X-C chemokine receptor type 4 (CXCR4) axis in promoting osseointegration is unknown. To study role SDF-1/CXCR4 osseointegration, we blocked pathway murine tibial implant model through repeated administrations an antibody against SDF-1. Methods: Using...