Blastic plasmacytoid dendritic cell neoplasm: a case report and review of literature

• DOI: 10.3760/cma.j.issn.1009-9921.2015.05.008
• Publication Date: 2015-05-25
• Authors: Zongmin Li; Ping Jiang; Xiaojun Guan; Naiguang Jiang; Yu Liu
• Keywords: Immunophenotyping; Interleukin-3 receptor; Neoplasm; Plasmacytoid dendritic cell

Objective To investigate the feature, pathological diagnosis and differential of blastic plasmacytoid dendritic cell neoplasm(BPDCN).

Methods The clinical histological findings, immunophenotype, treatment prognosis one case with BPDCN were evaluated review relevant literature.

Results The female patient age 32 years presented as cutaneous lesions. Pathologic findings showed skin bone marrow involved. Microscopically, tumors composed diffuse blasts small to medium size, scant cytoplasm, highly irregular nuclear contours, dispersed chromatin faint indistinct nucleolus. Immunohistochemical characteristics positive expression CD4, CD56 CD123, negative CD3, CD20, CD34, TdT, MPO.

Conclusion BPDCN is a rare aggressive hematopoietic neoplasm. Except for skin, lymph node can also be The necessary from other haematopoietic lymphoid tumors.

Key words: Blastic plasmcytoid neoplasm; Immunophenotype; Bone Marrow biopsy