A5016057251- Alzheimer's disease research and treatments
- Photochromic and Fluorescence Chemistry
- Retinal Development and Disorders
- Electrochemical sensors and biosensors
- Computational Drug Discovery Methods
- Chemical Synthesis and Analysis
- Wnt/β-catenin signaling in development and cancer
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
- Dementia and Cognitive Impairment Research
Scripps Research Institute
2024
Yonsei University
2020-2023
Abstract Pyroglutamate amyloid-β 3-42 (Aβ pE3-42 ) is an N-terminally truncated and pyroglutamate-modified Aβ peptide retaining highly hydrophobic, amyloidogenic, neurotoxic properties. In Alzheimer’s disease (AD) patients, peptides accumulate into oligomers induce cellular toxicity synaptic dysfunction. aggregates further seed the formation of amyloid plaques, which are pathological hallmarks AD. Given that play critical roles in development neurodegeneration, a reliable reproducible...
Alzheimer's disease (AD) is the most prevalent type of dementia and characterized by cognitive deficits accumulation pathological plaques. Owing to complexity AD development, paradigms for research drug discovery have shifted target factors that mediate multiple pathogenesis in AD. Increasing evidence suggests suppression Wnt/β-catenin signaling pathway plays substantial roles progression. However, underlying mechanism associated with remains unexplored. In this study, we identified CXXC5, a...