A5001702447- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Histone Deacetylase Inhibitors Research
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Memory and Neural Mechanisms
- Bioinformatics and Genomic Networks
- Nuclear Receptors and Signaling
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Estrogen and related hormone effects
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Pain Mechanisms and Treatments
- Nerve Injury and Rehabilitation
- NF-κB Signaling Pathways
Northwestern University
2015-2025
Northwestern University
2022
Northwest University
2022
Wuhan University of Science and Technology
2021
Jiangsu Second Normal University
2019
Zunyi Medical University
2014-2018
Beihang University
2017
Institute of Behavioral Sciences
2006-2014
Sichuan University
2014
West China Hospital of Sichuan University
2014
Objective: Studies of subjects with dementia the Alzheimer type have reported correlations between increases in activity hypothalamic-pituitary-adrenal (HPA) axis and hippocampal degeneration. In this study, authors sought to determine whether plasma cortisol, a marker HPA activity, were associated clinical cognitive measures rate disease progression Alzheimer-type dementia. Method: Thirty-three very mild 21 without assessed annually for up 4 years Clinical Dementia Rating scale battery...
Aggregation of the amyloid-beta (Abeta) peptide in extracellular space brain is critical pathogenesis Alzheimer's disease. Abeta produced by neurons and released into interstitial fluid (ISF), a process regulated synaptic activity. To determine whether behavioral stressors can regulate ISF levels, we assessed effects chronic acute stress paradigms amyloid precursor protein transgenic mice. Isolation over 3 months increased levels 84%. Similarly, restraint hours. Exogenous...
Conditional loss of BACE1 in adult mouse brain results abnormalities the hippocampal mossy fiber pathway, which is important for learning and memory.
Abstract Depression is a common and devastating neuropsychiatric symptom in the elderly patients with dementia. In particular, nearly 80% of Alzheimer’s Disease dementia experience depression during disease development progression. However, it unknown whether shares same molecular mechanisms as presenting primary psychiatric or occurs persists through alternative mechanisms. this review, we discuss how clinical presentation treatment differ between disease, focus on major depressive...
Although there is evidence that beta-amyloid impairs synaptic function, the relationship between and synapse loss not well understood. In this study we assessed density within hippocampus entorhinal cortex of Tg2576 mice at 6-18 months age using stereological methods both light electron microscope levels. Under microscopy failed to find overall decreases in synaptophysin-positive boutons any brain areas selected, but bouton was significantly decreased 200 mum compact plaques outer molecular...
Abstract Background Bone marrow mesenchymal stem cells (MSCs) are one of the potential tools for treatment spinal cord injury; however, survival and differentiation MSCs in an injured still need to be improved. In present study, we investigated whether Governor Vessel electro-acupuncture (EA) could efficiently promote bone differentiation, axonal regeneration finally, functional recovery transected cord. Results The cords adult Sprague-Dawley (SD) rats were completely at T10, five...
Significance Mutations in the UBQLN2 gene, which encodes ubiquitin-like protein ubiquilin2 (UBQLN2) have been shown to cause ALS and ALS/dementia. Ubiquilin2 links familial sporadic forms of disease through pathology observed spinal cords all cases brains ALS/dementia with or without mutations. In this communication, we develop characterize a mouse model mutant -linked dementia. We demonstrate that mice impairment degradation pathway, abnormal aggregation, synaptic dysfunction, cognitive...
Abstract Background The role of microglia in Alzheimer’s disease (AD) pathogenesis is becoming increasingly important, as activation these cell types likely contributes to both pathological and protective processes associated with all phases the disease. During early AD pathogenesis, one first areas degeneration locus coeruleus (LC), which provides broad innervation central nervous system facilitates norepinephrine (NE) transmission. Though LC-NE influence microglial dynamics, it unclear how...
Mechanisms of oligodendrocyte death after spinal cord injury (SCI) were evaluated by T9 level hemisection in wild-type mice (C57BL/6J and Bax+/+ mice), Wlds which severed axons remain viable for 2 weeks, deficient the proapoptotic protein Bax (Bax-/-). In lateral white-matter tracts, substantial was evident ipsilateral white matter 3-7 mm rostral caudal to site 8 d injury. Ultrastructural analysis expression anti-activated caspase-3 characterized ongoing at as primarily apoptotic....
The effects of kainic acid (KA) on neurogenesis in the developing rat hippocampus were investigated. Neonatal [postnatal day (P) 7] rats received a single bilateral intracerebroventricular infusion KA (50 nmol 1.0 μl) or vehicle. At P14, P25, P40, and P60, spatial temporal relationships between neurodegeneration induced by explored using terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL) to detect dying cells 5-bromodeoxyuridine (BrdU) label newly...