A5063204371- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Protein Degradation and Inhibitors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Streptococcal Infections and Treatments
- Ubiquitin and proteasome pathways
- Neonatal Respiratory Health Research
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Amphibian and Reptile Biology
- Cancer-related gene regulation
- Species Distribution and Climate Change
- Cell Adhesion Molecules Research
- Plant and animal studies
- FOXO transcription factor regulation
- Sarcoma Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
St. Jude Children's Research Hospital
2017-2025
Chinese Academy of Sciences
2020-2025
Institute of Zoology
2025
Shanghai Stomatological Hospital
2023
Fudan University
2015-2023
Zhejiang University
2007-2022
Sir Run Run Shaw Hospital
2016-2022
Washington University in St. Louis
2021
Northwestern University
2012-2020
Oregon College of Oriental Medicine
2005-2020
The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. To examine this possibility directly, adult mice were durably engrafted with BM isolated transgenic expressing enhanced GFP. Induction such chimera by endotracheal bleomycin (BLM) injection caused large numbers GFP(+) appear active fibrotic lesions, while only a few could identified control lungs....
The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. To examine this possibility directly, adult mice were durably engrafted with BM isolated transgenic expressing enhanced GFP. Induction such chimera by endotracheal bleomycin (BLM) injection caused large numbers GFP+ appear active fibrotic lesions, while only a few could identified control lungs....
Abstract FoxA1 (FOXA1) is a pioneering transcription factor of the androgen receptor (AR) that indispensible for lineage-specific gene expression prostate. To date, there have been conflicting reports on role in prostate cancer progression and prognosis. With recent discoveries recurrent mutations human tumors, comprehensive understanding function has become very important. Here, through genomic analysis, we reveal regulates two distinct oncogenic processes via disparate mechanisms. induces...
Polycomb repressive complexes (PRCs) play crucial roles in transcriptional repression and developmental regulation both plants animals. In plants, depletion of different members PRCs causes overlapping unique phenotypic defects. However, the underlying molecular mechanism determining target specificity functional diversity is not sufficiently characterized. Here, we quantitatively compared changes tri-methylation at H3K27 Arabidopsis mutants deprived various key PRC components. We show that...
Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic inactivation RB1 gene. Children germline mutations in have high likelihood retinoblastoma and other malignancies later life. Genetically engineered mouse models share some similarities human but there are differences their cellular differentiation. To develop laboratory model formation, we make induced pluripotent stem cells (iPSCs) from 15 participants mutations. Each cell lines validated,...
SUMMARY Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated comprehensive cell atlas of 55 neuroblastoma patient tumors, collected two institutions, spanning range clinical, genetic, histologic features. Our combines single-cell/nucleus RNA-seq (sc/scRNA-seq), bulk RNA-seq, whole exome sequencing, DNA methylation profiling, spatial transcriptomics, proteomic...
Long-term persistence of species with low genetic diversity is the focus widespread attention in conservation biology. The snow leopard, Panthera uncia, a big cat from high-alpine regions Asia. However, its subspecies taxonomy, evolutionary history, potential, and survival strategy remain unclear, which greatly hampers their conservation. We sequence high-quality chromosome-level genome leopard genomes 52 wild leopards. Population genomics reveal existence two large lineages global leopards,...
Abstract Found in inflammatory zone (FIZZ)1, also known as resistin-like molecule α, belongs to a novel class of cysteine-rich secreted protein family, named FIZZ/resistin-like molecule, with unique tissue expression patterns. FIZZ1 is induced alveolar type II epithelial cells (AECs) bleomycin (BLM)-induced lung fibrosis, and found induce myofibroblast differentiation vitro. The objective this study was elucidate the regulation AEC pulmonary fibrosis. AECs were isolated from rat lungs...
Abstract Innate immunity plays an important role in pulmonary host defense against Pneumocystis carinii, pathogen individuals with impaired cell-mediated immunity. We investigated the of GM-CSF a model P. carinii pneumonia induced by intratracheal inoculation CD4-depleted mice. Lung levels increased progressively during infection and were significantly greater than those uninfected controls 3, 4, 5 wk after inoculation. When gene-targeted mice (GM−/−) depleted CD4+ cells inoculated...
Chromosomal translocations juxtaposing the androgen-responsive TMPRSS2 promoter with ETS-family transcription factor ERG result in aberrant upregulation approximately 50% of prostate cancers. Studies to date have shown important roles inducing oncogenic properties cancer. Its molecular mechanisms action, however, are yet be fully understood. Here, we report that activates Wnt/LEF1 signaling cascade through multiple mechanisms. bound promoters various Wnt genes directly increase ligand...
The transcriptional activity of the androgen receptor (AR) is not only critical for normal development and function prostate but also pivotal to onset progression cancer (PCa). studies AR regulation were previously limited a handful AR-target genes. Owing various high-throughput genomic technologies, significant advances have been made in recent years. Here we discuss discoveries genome-wide androgen-regulated genes PCa cell lines, animal models tissues using expression microarray...
The histone acetyltransferase GCN5 has been suggested to be involved in promoting cancer cell growth. But its role human colon development remains unknown. Herein we discovered that expression is significantly upregulated adenocarcinoma tissues. We further demonstrate at the mRNA level. Surprisingly, two transcription factors, oncogenic c-Myc and proapoptotic E2F1, are responsible for transcription. Knockdown of inhibited proliferation largely through downregulating transcription, which can...
Degradation of RBM39 by indisulam leads to exceptional response in high-risk neuroblastoma.
A lack of relevant genetic models and cell lines hampers our understanding hepatoblastoma pathogenesis the development new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that recapitulates pathological features embryonal type hepatoblastoma, with transcriptomics resembling high-risk gene signatures human disease. Single-cell RNA-sequencing spatial identify distinct subpopulations cells. After deriving from mouse model, map cancer...
Abstract Langerhans cell histiocytosis (LCH) is an enigmatic histiocytic proliferative disorder of unknown etiology that affects children primarily. We have investigated the possibility viruses are etiological or they a “triggering effect” in LCH. Sensitive situ hybridization and polymerase chain reaction (PCR) techniques were used 56 cases sought failed to find evidence genomes for adenovirus, cytomegalovirus, Epstein‐Barr virus, herpes simplex human herpesvirus type 6, immunodeficiency...