A5056306660- Mast cells and histamine
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Effects and risks of endocrine disrupting chemicals
- Drug-Induced Hepatotoxicity and Protection
- Air Quality and Health Impacts
- Polyamine Metabolism and Applications
- Liver Disease Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Urticaria and Related Conditions
- Natural product bioactivities and synthesis
- Eicosanoids and Hypertension Pharmacology
- Seaweed-derived Bioactive Compounds
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Medicinal plant effects and applications
- Phytochemistry and Biological Activities
- Peroxisome Proliferator-Activated Receptors
- Redox biology and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Endoplasmic Reticulum Stress and Disease
- Lymphatic System and Diseases
- Sulfur Compounds in Biology
Catholic University of Daegu
2016-2025
Chungnam National University
2020-2022
Chungnam National University Hospital
2021
Kangwon National University
2013-2016
Yeungnam University
2009-2011
Yeungnam University College
2010
University of Missouri Hospital
2006-2009
University of Missouri
2005-2007
Many anticancer agents as well ionizing radiation have been shown to induce autophagy which is originally described a protein recycling process and recently reported play crucial role in various disorders. In HCT116 human colon cancer cells, we found that curcumin, polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced conversion of microtubule-associated 1 light chain 3 (LC3)-I LC3-II degradation sequestome-1 (SQSTM1) marker autophagosome degradation. Moreover,...
The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for treating inflammatory diseases. effects on OVA-induced asthmatic mice an Inulae Flos extract (IFE) were evaluated this study. anti-asthmatic IFE determined by observing eosinophil recruitment, airway hyper-responsiveness (AHR), Th2 cytokine and IgE levels, lung histopathology. treatment effectively reduced the percentage eosinophils cytokines bronchoalveolar lavage fluid (BALF) when compared to levels...
Abstract Sirt1, a key regulator of metabolism and longevity, has recently been implicated in the regulation allergic reactions, although underlying mechanism remains unclear. Here we show that Sirt1 negatively regulates FcεRI-stimulated mast cell activation anaphylaxis through two mutually regulated pathways involving AMP-activated protein kinase (AMPK) tyrosine phosphatase 1B (PTP1B). Mast cell-specific knockout dampened AMPK-dependent suppression FcεRI signaling, thereby augmenting both...
Alcoholic liver disease (ALD) is a worldwide health problem and hepatocyte apoptosis has been associated with the development/progression of ALD. However, no definite effective pharmacotherapy for ALD currently available. Cilostazol, selective type III phosphodiesterase inhibitor shown to protect hepatocytes from ethanol-induced apoptosis. In present study, underlying mechanisms protective effects cilostazol were examined. Primary rat treated ethanol in presence or absence cilostazol. Cell...
Hyaluronic acid (HA), a ligand of CD44, accumulates in some types tumors and is responsible for tumor progression. The nuclear factor erythroid 2-like 2 (NRF2) regulates cytoprotective genes drug transporters, which promotes therapy resistance tumors. Previously, we showed that high levels CD44 are associated with NRF2 activation cancer stem like-cells. Herein, demonstrate HA production was increased doxorubicin-resistant breast MCF7 cells (MCF7-DR) via the upregulation synthase-2 (HAS2)....
Mast cells are central players in immediate-type hypersensitvity and inflammatory responses. In the present study, effects of britanin on passive cutaneous anaphylaxis (PCA) reaction mice phorbol 12-myristate 13-acetate calcium ionophore A23187 (PMACI)-induced production pro-inflammatory cytokines human mast cell line (HMC-1) were evaluated. The oral administration (10–20 mg/kg) decreased cell-mediated PCA IgE-sensitized mice. activity mechanism vitro assay, suppressed gene expression...
Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in RatsThis study was conducted to evaluate whether the composition carbohydrate or fat diet affects insulin resistance by measuring muscle glucose transport rate.Both highsucrose high-starch with without high-fat decreased insulin-stimulated transport, but there were no significant differences among groups.Calorie intake both high-sucrose groups higher than chow group.The induced decrease...
Alcoholic hepatitis is a leading cause of liver failure in which the increased production tumor necrosis factor α (TNFα) plays critical role progression alcoholic disease. In present study, we investigated effects cilostazol, selective inhibitor type III phosphodiesterase on ethanol-mediated TNFα vitro and vivo, effect cilostazol was compared with that pentoxifylline, currently used clinical trial. RAW264.7 murine macrophages were pretreated ethanol presence or absence then, stimulated...