A5074620324- Advanced Sensor and Energy Harvesting Materials
- Electronic Packaging and Soldering Technologies
- Cancer Cells and Metastasis
- Conducting polymers and applications
- Cancer, Hypoxia, and Metabolism
- Intermetallics and Advanced Alloy Properties
- Knee injuries and reconstruction techniques
- Aluminum Alloys Composites Properties
- Advanced ceramic materials synthesis
- Educational Robotics and Engineering
- Engineering Education and Curriculum Development
- Gold and Silver Nanoparticles Synthesis and Applications
- IoT-based Smart Home Systems
- Thermal properties of materials
- Epoxy Resin Curing Processes
- Synthesis and properties of polymers
- Cancer Research and Treatments
- Asymmetric Synthesis and Catalysis
- 3D IC and TSV technologies
- 3D Printing in Biomedical Research
- Nanomaterials and Printing Technologies
- Total Knee Arthroplasty Outcomes
- Smart Materials for Construction
- Pancreatic function and diabetes
- X-ray Diffraction in Crystallography
Kyoto University
2012-2025
Chiba University
2004-2025
Mitsubishi Electric (United States)
2025
Gunma University
2015-2024
Osaka International Cancer Institute
2017-2023
Daiichi-Sankyo (Japan)
2014-2023
Keio University
1997-2023
Futaba clinic
2023
Fukuda Denshi (Japan)
2023
Daiichi Sankyo (Germany)
2014-2023
A mouse model involving the human papillomavirus type-16 oncogenes develops cervical cancers by lesional stages analogous to those in humans. In this study angiogenic phenotype was characterized, revealing intense angiogenesis high-grade intraepithelial neoplasias (CIN-3) and carcinomas. MMP-9, a proangiogenic protease implicated mobilization of VEGF, appeared stroma concomitant with switch, expressed infiltrating macrophages, similar what has been observed Preclinical trials sought target...
Primary culture of the cancer cells from patients’ tumors can provide crucial information individual tumors, yet technology has not been optimized until now. We developed an innovative method for primary colorectal cells, based on principle that cell–cell contact was maintained throughout process. When tumor tissue dissociated into cell clusters, in which retained, they rapidly formed spheroids we termed tissue-originated (CTOSs). CTOSs consisted highly purified and viable were prepared with...
In order to assess the healing of medial collateral ligament (MCL) and detect various effects treatment regimens, in vivo animal experiments using a canine model were performed. Thirty-five MCLs surgically transected treated three clinically popular e.g., no repair with cage farm activities (Group 1), 3 weeks immobilization 2), 6 im mobilization 3). The varus-valgus laxity knee joint, structural properties femur-MCL-tibia (FMT) complex mechanical MCL substance (healing site) quantitatively...
To investigate intraarticular lesions producing persist ent postoperative pain, we arthroscopically examined 31 ankles in patients (15 women and 16 men) with lateral ligament injury. The ranged age from 15 to 33 years, a mean of 20 years. Nine were freshly injured, 22 had chronic inju ries. All the underwent arthroscopic exami nation immediately before operation. Chondral found 89% injured 95% injuries. Most these medial half ankle joint, especially anteromedial edge tibial plafond. After...
An electromagnetic theory for the light absorption by a cluster of metal spheres and Raman scattering molecule adsorbed on it is presented, which takes into account retardation effect exactly applicable to an arbitrary size. The applied two-sphere Ag Au. It shown that spectrum doubly peaked maximum enhancement factor intensity amounts 10 7 ∼10 8 when distance between decreased. Absorption spectra three- four-sphere clusters are also calculated, indicate essential features experimental...
The purpose of this study was to explain the functional roles medial collateral ligament (MCL) and ACL how they affect kinematics knee joint after isolated MCL injury. Varus-valgus laxity quantitatively measured using a device which allowed various degrees freedom (DOF) motion during application varus-valgus bending moment canine joint. When limited 3 DOF (varus-valgus rotation, proximal-distal, medial-lateral translation), valgus increased significantly (171%) sectioning MCL. Thus, primary...
Tumour recurrence frequently occurs after radiotherapy, but the characteristics, intratumoural localization and post-irradiation behaviour of radioresistant cancer cells remain largely unknown. Here we develop a sophisticated strategy to track fate cells, which exist in perinecrotic regions at time radiation. Although tumour are originally hypoxia-inducible factor 1 (HIF-1)-negative, they acquire HIF-1 activity surviving radiation, triggers their translocation towards blood vessels....
We have performed an arthroscopic and histological study of the remodelling process allogeneic tendons transplanted into human knee as anterior cruciate ligament substitutes. Arthroscopic observations from six weeks to 55 months after operation showed that grafts were viable, early surface hypervascularity subsided with time; moreover, these appearances remained unchanged 11 postoperatively onwards. Histological studies three all infiltrated fibroblasts, cellularity in their substance...
// Akira Okita 1, 2 , Shin Takahashi Kota Ouchi Masahiro Inoue 3 Mika Watanabe 4 Mareyuki Endo 5 Hiroshi Honda 6 Yasuhide Yamada 7, 8 and Chikashi Ishioka 1 Department of Clinical Oncology, Institute Development, Aging Cancer, Tohoku University, Aoba-ku, Sendai, Japan Medical University Hospital, Akita Graduate School Medicine, Akita, Pathology, Aobaku, Sendai Kousei Surgery, Rosai 7 Hamamatsu Higashiku, Hamamatsu, National Center for Global Health Tokyo, Correspondence to: Ishioka, email:...
Abstract Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small lung cancer (NSCLC) distinct in their histological, molecular clinical presentation. However, metabolic signatures specific to individual NSCLC remain unknown. Here, we perform an integrative analysis human tumour samples, patient-derived xenografts, murine model NSCLC, lines The Cancer Genome Atlas (TCGA) reveal a markedly elevated expression GLUT1 glucose transporter SqCC, which...
Patient‐derived cancer organoid culture is an important live material that reflects clinical heterogeneity. However, the limited amount of organoids available for each case as well considerable time and cost to expand in vitro makes it impractical perform high‐throughput drug screening using cultures from multiple patients. Here, we report advanced system 2427 drugs tissue‐originated spheroid ( CTOS ) method. In this system, apply method ex vivo platform xenograft tumors, machines handle...
Squamous cell carcinoma (SCC), a malignancy arising across multiple anatomical sites, is responsible for significant cancer mortality due to insufficient therapeutic options. Here, we identify exceptional glucose reliance among SCCs dictated by hyperactive GLUT1-mediated influx. Mechanistically, squamous lineage transcription factors p63 and SOX2 transactivate the intronic enhancer cluster of SLC2A1. Elevated influx fuels generation NADPH GSH, thereby heightening anti-oxidative capacity in...
One hundred eighty-seven patients who had undergone intraarticular anterior cruciate ligament reconstruction using either a fresh-frozen allogeneic tendon or central third autogenous pateller 3 to 89 months previously were arthroscopically evaluated. The focus was on secondary changes of the patellofemoral joint at time second-look arthroscopy. Overall, 93 knees deteriorated, 74 remained unchanged, and 14 improved. deteriorative predominantly located around ridge patellae, although all but...
Eighty-four patients who underwent ACL reconstruction with fresh-frozen allogeneic tendon were reviewed and evaluated subjective functional rating scales, physical examinations, instrumented anterior drawer tests, isokinetic testing, arthroscopy. The average followup was 57 months (range, 36 to 90 months) the age at operation 22 years 16 37 years). results rated as excellent in 48 (57%), good 31 (37%), fair 2 (2%). Three (3%) experienced a retear of ACL. Physical examinations tests showed...
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