A5089454871- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Tracheal and airway disorders
- Reconstructive Surgery and Microvascular Techniques
- Silk-based biomaterials and applications
- Nanoplatforms for cancer theranostics
- Tendon Structure and Treatment
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Apelin-related biomedical research
- Conducting polymers and applications
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Laser Applications in Dentistry and Medicine
- Sirtuins and Resveratrol in Medicine
- Neuropeptides and Animal Physiology
- Renal and Vascular Pathologies
- Vascular Anomalies and Treatments
- Cancer Mechanisms and Therapy
Shanghai Ninth People's Hospital
2022-2025
Shanghai Jiao Tong University
2021-2025
Universitätsklinikum Erlangen
2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2025
Hainan General Hospital
2024
Hainan Medical University
2024
Tongji University
2024
Nantong University
2018-2019
Tendon injuries, prevalent in clinical settings, predominantly arise from the disruption of collagen matrix and are typically accompanied by pronounced inflammatory responses perturbations tendon's intrinsic electrical microenvironment. Despite advancements bridging tendon few strategies currently target restoration native microenvironment to facilitate repair. Herein, we fabricated electrospun fibers composed polycaprolactone (PCL) loaded with dopamine (PDA) modified piezoelectric...
Conventional wound dressings for infected diabetic wounds (IDWs) typically target only the surface, often neglecting need multifunctional therapies that address deeper tissue layers, resulting in less effective treatment outcomes. Emerging research suggests a comprehensive approach to IDW therapy should involve transdermal delivery of therapeutic agents capable staged bacterial eradication, reactive oxygen species (ROS) scavenging, and angiogenesis. This study introduces novel metal-phenolic...
Keloids pose a considerable worldwide health issue owing to their continual proliferation, invasiveness, and elevated recurrence rates. are abnormal scars formed through dysregulated wound healing processes, characterized by excessive keloid fibroblast (KF) irregular collagen deposits, persistent reticular dermis inflammation, which can lead limited joint mobility, psychological distress, severe pain itching. In this study, we present metal–organic framework (MOF)-derived TiO2-based...
The reconstruction of a stable, nipple-shaped cartilage graft that precisely matches the natural nipple in shape and size on contralateral side is clinical challenge. While 3D printing technology can efficiently accurately manufacture customized complex structures, it faces limitations due to inadequate blood supply, which hampers stability grafts produced using this technology. To address issue, we employed biodegradable biomaterial, Poly(lactic-co-glycolic acid) (PLGA), loaded with...
Abstract Peripheral nerve injuries resulting from various traumatic events can cause mobility problems and sensory impairment, jeopardizing patients’ life quality bringing serious economic burdens. Due to the shortcomings of autologous grafts, such as limited tissue sources, unmatched size, loss innervation at donor site, tissue-engineered grafts using both natural synthetic materials have been employed in treatment peripheral defect promote regeneration. Apart traditional advantages good...
Artificial tracheal substitutes encounter significant challenges during long-segmental defects (LSTD) reconstruction, notably early postoperative anastomotic stenosis and chondromalacia. Mitigating by creating a compliant sutureless substitute is pivotal. Enhancing its chondrogenic capacity equally critical for sustained healthy cartilage regeneration. This study proposes self-healing hydrogel anastomosis to mitigate stenosis, enriched with kartogenin (KGN) transforming growth factor-β1...
Neuropeptide Y (NPY) is an abundant neuropeptide in the mammalian central and peripheral nervous systems. Transgenic mice overexpressing NPY noradrenergic neurons have increased level of hepatic triglycerides, fatty acids cholesterol, which contributed to development hepatosteatosis. However, roles activation stellate cells (HSCs) underlying mechanisms remain unclear. This study aimed investigate expression secretion human immortalized HSC LX-2 regulatory function on fibrogenic response...
Alternative splicing of tau exon 10 generates isoforms with three or four microtubule binding repeats, named 3R-tau and 4R-tau, respectively.Dysregulation could cause neurofibrillary degeneration.Acetylation is one the major post-translational protein modifications in cell by attachment acetyl group to either α-amino N-terminus proteins ε-amino lysine residues.Sirt1, member mammalian Sirtuin family, deacetylates associated closely age-related diseases including Alzheimer's disease.However,...
Abstract Inducing an anti-inflammatory response before neurogenesis is crucial in effectively addressing peripheral nerve damage. Herein, we developed shell-core-structured nanofilms (Cur/PLCL@BDNF/CNT) using poly-( l -Lactide)-Caprolactone (PLCL) and curcumin (Cur, agent) as the shell layer, carbon nanotubes (CNT) brain-derived neurotrophic factor (BDNF, a neurogenic factor) core via coaxial electrospinning technology. The resulting Cur/PLCL@BDNF/CNT film exhibited characteristic fibrous...
ABSTRACT: Recurrent glioblastoma (rGBM) is a highly aggressive form of brain cancer that poses significant challenge for treatment in neurooncology, and the survival status patients after relapse usually means rapid deterioration, also leading cause death among patients. In recent years, immunotherapy has emerged as promising strategy recurrent by stimulate body's immune system to recognize attack cells , which could be used combination with other treatments such surgery, radiation,...
<title>Abstract</title> The reconstruction of a stable, nipple-shaped cartilage graft that precisely matches the natural nipple in shape and size on contralateral side is clinical challenge. While 3D printing technology can efficiently accurately manufacture customized complex structures, it faces limitations due to inadequate blood supply, which hampers stability grafts produced using this technology. To address issue, we employed biodegradable biomaterial, Poly(lactic-co-glycolic acid)...
Cartilage tissue engineering offers hope for tracheal cartilage defect repair. Establishing an anti-inflammatory microenvironment stands as a prerequisite successful restoration, especially in immunocompetent animals. Hence, scaffolds inducing response before chondrogenesis are crucial effectively addressing defects. Herein, we develop shell-core structured PLGA@ICA-GT@KGN nanofilm using poly(lactic-co-glycolic acid) (PLGA) and icariin (ICA, drug) the shell layer gelatin (GT) kartogenin...
Objective To explore the preparation method, physical and chemical properties, biocompatibility of a conductive composite scaffold based on polypyrrole/silk fibroin (PPy/SF) fiber with shell-core structure, to provide preliminary research basis for application in field tissue engineered neuroscience. Methods The fibers structure were prepared by three-dimensional printing combined in-situ polymerization. PPy/SF fiber-based scaffolds formed electrospinning. In addition, core-free PPy SF...