A5070928572- Dermatologic Treatments and Research
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Connective Tissue Growth Factor Research
- Collagen: Extraction and Characterization
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Sports injuries and prevention
- Tissue Engineering and Regenerative Medicine
- Kruppel-like factors research
- Software System Performance and Reliability
- Laser Applications in Dentistry and Medicine
- Remote Sensing in Agriculture
- Fungal Plant Pathogen Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Polymer Surface Interaction Studies
- ATP Synthase and ATPases Research
- Pregnancy and Medication Impact
- Vascular Tumors and Angiosarcomas
- Surgical Sutures and Adhesives
- COVID-19 Impact on Reproduction
- Angiogenesis and VEGF in Cancer
- Hair Growth and Disorders
Shanghai Ninth People's Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2020-2021
Sun Yat-sen University
2020-2021
Beijing Obstetrics and Gynecology Hospital
2020
Capital Medical University
2020
Army Medical University
2017
Southwest Hospital
2017
Traditional Chinese medicine (TCM) with the characteristics of "multi-component-multi-target-multi-pathway" has obvious advantages in prevention and treatment complex diseases, especially aspects "treating same disease different treatments". However, there are still some problems such as unclear substance basis molecular mechanism effectiveness formula. Network pharmacology is a new strategy based on system biology poly-pharmacology, which could observe intervention drugs networks at...
Complex disease is a cascade process which associated with functional abnormalities in multiple proteins and protein-protein interaction (PPI) networks. One drug one target has not been able to perfectly intervene complex diseases. Increasing evidences show that Chinese herb formula usually treats diseases the form of multi-components multi-targets. The key step elucidate underlying mechanism traditional medicine (TCM) optimize capture important components formula. At present, there are...
Abstract Keloid is considered as a tumor‐like skin disease with multiple aetiologies including immunological factors and mechanical microenvironment. Macrophages are plastic diverse immune cells that play critical role in maintaining tissue homeostasis by removing dead cells, debris, pathogens repairing tissues after inflammation. The imbalance of M1/M2 macrophages disturbances macrophage functions can steer the progression chronic inflammation lead to development pathological fibrosis...
Native-like endothelium regeneration is a prerequisite for material-guided small-diameter vascular regeneration. In this study, novel strategy proposed to achieve phase-adjusted endothelial healing by step-wise modification of parallel-microgroove-patterned (i.e., micropatterned) nanofibers with polydopamine-copper ion (PDA-Cu2+) complexes, polylysine (PLys) molecules, and Cys-Ala-Gly (CAG) peptides (CAG@PLys@PDA-Cu2+). Using electrospun poly(l-lactide-co-caprolactone) random as the...
The pathogenesis of diabetic nephropathy (DN) is accompanied by alterations in biological function and signaling pathways regulated through complex molecular mechanisms. A number regulatory factors, including transcription factors (TFs) non-coding RNAs (ncRNAs, lncRNAs miRNAs), have been implicated DN; however, it unclear how the interactions among these contribute to development DN pathogenesis. In this study, we developed a network-based analysis decipher interplays between TFs ncRNAs...
Our previous work demonstrated the tendon-derived extracellular matrix (ECM) extracts as vital niches to specifically direct mesenchymal stem cells towards tenogenic differentiation. This study aims further define effective ECM molecules capable of teno-lineage induction on human adipose-derived (hASCs) and test their function for tendon engineering. By detecting teno-markers expression levels in hASCs exposed various substrate coatings, collagen I (COL1) fibromodulin (FMOD) were identified...
Abstract Biomimetic dressings are considered as one of the ideal medical to combat bacterial infections, shorten tissue regeneration process, and facilitate wound repair. Researchers committed developing a new generation with unique functions promote repair healing. Here, strategy for composite nanofiber membrane construction based on natural biopolymers HA, Gel PLGA carrying vascular endothelial growth factor (VEGF) was provided pro-angiogenic The prepared by electrospinning technology can...
<b><i>Objective:</i></b> This study investigates the synergistic effects of Gleevec (imatinib) and rapamycin on proliferative angiogenic properties mouse bone marrow-derived endothelial progenitor cells (EPCs). <b><i>Materials Methods:</i></b> EPCs were isolated from marrow treated with different concentrations or individually in combination. The cell viability proliferation examined using MTT assay. An analysis cycle apoptosis was performed...
The treatment of keloids, particularly in high‐tension areas, is challenging due to their extension beyond the original wound boundaries and high recurrence rates, thereby rendering traditional treatments ineffective. In this study, we investigated effectiveness a novel single‐stage approach that combined acellular dermal matrix (ADM) with keloid‐specific epidermal skin grafting. To further prevent after neo‐skin formation, was followed by fractionated laser radiation therapy (LCR). Seven...
Gliomas are the most common tumors of central nervous system, with glioblastoma (GBM) being particularly aggressive and fatal. Current treatments for GBM, including surgery chemotherapy, limited by tumor aggressiveness blood-brain barrier. Therefore, understanding molecular mechanisms driving GBM growth is essential. Mitochondria, key players in cellular energy production, have been implicated cancer development. In this study, we investigated expression mitochondrial transcription...
The effect of stereoscopic cultivation on the growth, photosynthetic characteristics and yield Tulipa edulis was studied to explore feasibility efficient T.edulis. Total leaf area parameters T.edulis under (the upper, middle lower layers ) control were measured using LI-3100 meter LI-6400XT photosynthesis system in growing peak period T.edulis.Plant biomass allocation also determined.In addition, bulb regeneration harvesting time.The results indicated that layer cultivation, proportion...
Objectives: The mechanistic target of rapamycin (mTOR) controls cell growth and proliferation via translation regulation in eukaryotes. present study investigated the effects mTOR on differentiation tendon stem cells (TSCs). Methods: ability TSCs was tested response to antagonist (MHY1485), a depressor (Rapamycin KU0063794). CCK test performed proliferation; quantitative real-time PCR (RT-PCR) Western blot were evaluate TSCs. Results: Blocking mTOR1 inhibited blocking mTOR2 enhanced TSCs;...
The driving cycles for testing (i.e. DC) are the basis of automotive performance testing. Generally, because lack key data, such as air-conditioning usage, whole vehicle loading, selection shift gears, and so on, significant difference between results DC actual road cannot be reduced when was developed. So factors were studied in this paper, including air-conditioner usage characteristics its effects on automotive’s fuel consumption. Three typical cities, Changchun, Hefei Nanchang,...