A5100355823- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Total Knee Arthroplasty Outcomes
- Mesenchymal stem cell research
- Neuropeptides and Animal Physiology
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Tissue Engineering and Regenerative Medicine
- Osteoarthritis Treatment and Mechanisms
- Advancements in Battery Materials
- Nanoplatforms for cancer theranostics
- Advanced Battery Materials and Technologies
- Additive Manufacturing and 3D Printing Technologies
- Extracellular vesicles in disease
- Pelvic and Acetabular Injuries
- Catalytic Processes in Materials Science
- Electrocatalysts for Energy Conversion
- Receptor Mechanisms and Signaling
- Bone and Joint Diseases
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Dental materials and restorations
Peking University
2025
Ningxia Medical University
2025
Second Affiliated Hospital of Jilin University
2020-2024
First Affiliated Hospital of Bengbu Medical College
2020-2024
Bengbu Medical College
2024
Southern University of Science and Technology
2021-2024
Hankou University
2024
Fuzhou University
2023-2024
Beijing Academy of Quantum Information Sciences
2024
Lanzhou University of Technology
2024
We report the isolation of a cDNA clone named GPR54, which encodes novel G protein-coupled receptor (GPCR). A PCR search rat brain retrieved partially encoding GPCR. In library screening this was used to isolate with an open reading frame (ORF) 396 amino acids long shared significant identities in transmembrane regions galanin receptors GalR1 (45%), GalR3 (45%) and GalR2 (44%). Northern blot situ hybridization analyses revealed that GPR54 is expressed (pons, midbrain, thalamus, hypothalamus,...
The morphologies and structures of the scaffold have a significant influence on their mechanical biological properties. In this work, different types porous structures: Triply periodic minimal surface-Schwarz primitive (P), body-centered cubic, cubic pore-shaped (CPS) hydroxyapatite scaffolds with ~70% porosity were fabricated through digital light processing (DLP) 3D printing technology. compressive properties in vitro cell evaluations such as proliferation attachment morphology these...
Reconstruction of osteochondral (OC) defects represents an immense challenge due to the need for synchronous regeneration special stratified tissues. The revolutionary innovation bioprinting provides a robust method precise fabrication tissue-engineered OCs with hierarchical structure; however, their spatial living cues simultaneous fulfilment osteogenesis and chondrogenesis reconstruct cartilage-bone interface OC are underappreciated. Here, inspired by natural bilayer features, anisotropic...
Abstract Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Optical imaging through near-infrared-II window (NIR-II, 1000–1700 nm) can penetrate deep tissues without risk, targeting of contrast agent is non-specific. Here, we report that lanthanide-doped nanocrystals passively target bone marrow, which be effective for over two months. We therefore develop high-resolution NIR-II method disease diagnosis, including 3D instrumentation to show...
Background: Mechanical loading and alendronate (ALN) can be used as noninvasive physical therapy methods for osteoarthritis (OA). However, the timing efficacy treatments are unknown. Purpose: To determine whether of mechanical ALN influences pathobiological changes OA. Study Design: Controlled laboratory study. Methods: Mice with OA induced by anterior cruciate ligament transection were subjected to early (1-3 weeks) or late (5-7 axial compressive dynamic load intraperitoneal injection ALN....
Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive cannot provide sufficient spatial temporal resolutions for regular of gastrointestinal (GI) tract to guide prognosis therapy GI diseases. Here we report a non-invasive method optical tract. It is based on new type lanthanide-doped nanocrystal with near-infrared (NIR) excitation at 980 nm second NIR window (NIR-IIb) (1500~1700 nm) fluorescence emission around 1530 nm. The rational...
Wear particle-induced osteoclast over-activation is a major contributor to periprosthetic osteolysis and aseptic loosening, which can cause pathological bone loss destruction. Hence, inhibiting excessive osteoclast-resorbing activity an important strategy for preventing osteolysis. Formononetin (FMN) has been shown have protective effects against osteoporosis, but no previous study evaluated the of FMN on wear In this study, we found that alleviated CoCrMo alloy particles (CoPs)-induced in...
Anyons, exotic quasiparticles in two-dimensional space exhibiting nontrivial exchange statistics, play a crucial role universal topological quantum computing. One notable proposal to manifest the fractional statistics of anyons is toric code model; however, scaling up its size through simulation poses serious challenge because highly entangled ground state. In this Letter, we demonstrate that modular superconducting processor enables hardware-pragmatic implementation model. Through...
Paraneoplastic pemphigus (PNP) is a rare and potentially fatal autoimmune disease that primarily affects the mucocutaneous tissues. Here we present clinical features of patient with lichenoid variant PNP involving oral mucosa only. The exhibited manifestations resembling both lichen planus pemphigus, yet these lesions remained unresponsive to corticosteroid therapy. A chest computed tomography (CT) scan revealed Castleman disease. Following surgical removal tumor, patient’s healed...
ABSTRACT This study aimed to investigate the impact of in vitro low‐dose arachidonic acid (AA) addition on enhancing sperm motility obese infertile men with asthenozoospermia. Semen samples were collected from 115 men, categorized into two BMI groups: 18.5–23.9 kg/m 2 and ≥ 28 , all subjects demonstrating a concentration 15 × 10 6 /mL. These further divided four cohorts based percentage progressive (PR): control‐normal, control‐asthenozoospermia, obese‐normal, obese‐asthenozoospermia. Normal...
S-acylation is a widespread lipidation form in eukaryotes which various fatty acids can be covalently attached to specific cysteine residues. However, due the low reactivity of lipid moieties and lack antibodies, purification intact S-acylated peptides remains challenging. Here, we developed pretreatment method for direct separation global analysis endogenously by nanographite fluoride-based solid-phase extraction (nGF-SPE), together with investigation optimization enrichment procedure as...
Purpose: To investigate the protective effect of naringin (Nar) on H2O2-induced apoptosis nucleus pulposus-derived mesenchymal stem cells (NPMSC) and potential mechanism in this process.Methods: Rat NPMSC were cultured MSC culture medium or with different concentrations H2O2. Nar combination LY294002 was added into to effects Nar. Cell viability evaluated by cell counting kit-8 (CCK-8) assay. The rate determined using Annexin V/PI dual staining terminal deoxynucleotide transferase-mediated...
Microrobots can expand our abilities to access remote, confined, and enclosed spaces. Their potential applications inside body are obvious, e.g., diagnose diseases, deliver medicine, monitor treatment efficacy. However, critical requirements exist in relation their operations gastrointestinal environments, including resistance strong gastric acid, responsivity a narrow proton variation window, locomotion confined cavities with hierarchical terrains. Here, we report proton-activatable...