A5051330682- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Bone fractures and treatments
- Total Knee Arthroplasty Outcomes
- Spine and Intervertebral Disc Pathology
- Knee injuries and reconstruction techniques
- Anesthesia and Pain Management
- Lower Extremity Biomechanics and Pathologies
- Spinal Hematomas and Complications
- Advanced X-ray and CT Imaging
- Bone Metabolism and Diseases
- Bone health and treatments
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
Jinan University
2021-2025
Southern University of Science and Technology
2021-2024
University of Colorado Anschutz Medical Campus
2019-2024
First Affiliated Hospital of Zhengzhou University
2016-2022
Background: Mechanical loading and alendronate (ALN) can be used as noninvasive physical therapy methods for osteoarthritis (OA). However, the timing efficacy treatments are unknown. Purpose: To determine whether of mechanical ALN influences pathobiological changes OA. Study Design: Controlled laboratory study. Methods: Mice with OA induced by anterior cruciate ligament transection were subjected to early (1-3 weeks) or late (5-7 axial compressive dynamic load intraperitoneal injection ALN....
Abstract The physis is a cartilaginous tissue in children's long bones that responsible for bone elongation. Physeal injuries can heal with bony repair known as “bony bar,” and this cause growth deformities. Current treatments involve surgical resection of the bar insertion inert materials hopes preventing re‐formation preserving However, these frequently fail commonly returns. This study investigated alginate–chitosan hydrogels interpositional to block formation rat model physeal injury....
Abstract Growth plate injuries affecting the pediatric population may cause unwanted bony repair tissue that leads to abnormal bone elongation. Clinical treatment involves bar resection and implantation of an interpositional material, but success is limited often reforms. No attempts regenerate growth cartilage. Herein we develop a 3D printed mimetic composite as potential regenerative medicine approach with goal preventing limb length discrepancies inducing cartilage regeneration. A...
Human adipose-derived stem cells (ADSCs) exert a strong anti-inflammatory effect, and synovium-derived (SDSCs) have high chondrogenic potential. Thus, this study aims to investigate whether combination of human ADSCs SDSCs will synergistic effect that increase the potential osteoarthritis (OA) chondrocytes in vitro attenuate cartilage degeneration early advanced OA vitro. ADSCs, SDSCs, were isolated from patients who underwent total knee arthroplasty. The ADSCs–SDSCs mixed cell ratios 1:0...
Physeal injuries can lead to bony repair tissue formation, known as a bar. This result in growth arrest or angular deformity, which is devastating for children who have not yet reached their full height. Current clinical treatment involves resecting the bar and replacing it with fat graft prevent further bone formation disturbance, but these treatments frequently fail do so require additional interventions. Novel that could also regenerate injured physeal cartilage restore normal elongation...
Physeal injuries can result in the formation of a "bony bar" which lead to bone growth arrest and deformities children. Vascular endothelial factor (VEGF) has been shown play role bony bar formation, making it potential target inhibit repair tissue after physeal injury. The goal this study was investigate whether local delivery anti-VEGF antibody (α-VEGF; 7.5 μg) from alginate:chitosan hydrogels tibial injury site rats prevents formation. We tested effects quick or delayed α-VEGF using both...
Rat spine fusion model.The present study aimed to determine whether administration of osteoprotegerin (OPG) in a rat model spinal increases bone volume, density, and decreases osteoclasts the mass.OPG is soluble RANK-ligand inhibitor that blocks osteoclast differentiation activation. This makes it potential agent control remodeling process enhance mass during fusion.Forty-eight male Sprague-Dawley rats received one-level L4-L5 with allograft. Rats were then divided into four groups according...
Knee Osteoarthritis is one of the most common degenerative diseases. Although morbidity knee osteoarthritis increases dramatically, there no effective medication that can repair damaged articular cartilage and restore joint function. Recently, with technical development cell transplantation regulation, more attentions have been paid in this area. The techniques included osteochondral autograft transplantation, mosaicplasty, chondrocytes based matrix-induced autologous chondrocyte...