A5101778763- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Cell Adhesion Molecules Research
- Phytochemistry and Bioactivity Studies
- Tissue Engineering and Regenerative Medicine
- Reproductive System and Pregnancy
- TGF-β signaling in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Caveolin-1 and cellular processes
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Endometriosis Research and Treatment
- Renal and related cancers
- Natural Compounds in Disease Treatment
- Enzyme function and inhibition
- Phytochemistry and Bioactive Compounds
- Cancer-related gene regulation
Peking University First Hospital
2024
Peking University
2024
Breast Cancer Research Foundation
2024
Wuhan University of Science and Technology
2015-2021
Obstetrics and Gynecology Hospital of Fudan University
2005-2020
Shanghai Medical College of Fudan University
2005-2020
Zhejiang Pharmaceutical College
2020
Wuhan Hankou Hospital
2018-2020
Wuhan Puai Hospital
2019
Yanbian University Hospital
2017
Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis. To better understand the Snail metastasis ovarian carcinoma, expression was knocked down by antisense-Snail highly metastatic cell line HO8910PM. Gene array analysis revealed that blocking suppressed activity matrix metalloproteinases (MMPs) and upregulated TIMP3, MMP inhibitor. These findings suggest interacts with during tumor invasion In addition, we examined orthotopic model...
Recent studies have highlighted the role of long non-coding RNAs (lncRNAs) in carcinogenesis and suggested that genes this class might be used as biomarkers cancer. However, whether lncRNAs are involved serous ovarian cancer (SOC) remains largely unknown. In present study, we focused on lncRNA antisense RNA INK4 locus (ANRIL) investigated its expression pattern, clinical significance, biological function SOC. We found ANRIL levels were elevated SOC tissues compared with normal controls...
Phyllanthus niruri L. is a well-known hepatoprotective and antiviral medicinal herb. Recently, we identified Corilagin as major active component with anti-tumor activity in this herbal medicine. member of the tannin family that has been discovered many plants used an anti-inflammatory agent. However, there have few reports effects Corilagin, its mechanism not investigated clearly. The aim present study to investigate anticancer properties ovarian cancer cells.The cell lines SKOv3ip, Hey...
Abstract Persistent unopposed estrogen stimulation is a central oncogenic mechanism driving the formation of type I endometrial cancer. Recent epidemiologic and clinical studies cancer have also revealed role for insulin resistance, clinically manifested by chronic inflammation. However, inflammation in estrogen-driven not well characterized. In this study, we investigated association between infiltrating macrophages sensitivity Evaluating tissue samples serum from patients with precancerous...
ErbB2+ human breast cancer is a major clinical problem. Prior results have suggested that tetraspanin CD151 might contribute to ErbB2-driven growth, survival, and metastasis. In other types, sometimes supports tumor growth However, definitive test of effects on de novo initiation, metastasis has not previously been done. We used gene-deleted mice expressing the MMTV-ErbB2 transgene show strongly mammary initiation Delayed onset (by 70-100 days) in absence was accompanied by reduced survival...
Abstract Background ARHI is a Ras-related imprinted gene that inhibits cancer cell growth and motility. downregulated in the majority of breast cancers, loss its expression associated with progression from ductal carcinoma situ (DCIS) to invasive disease. In ovarian cancer, re-expression induces autophagy leads autophagic death culture; however, enables cells remain dormant when they are grown mice as xenografts. The purpose this study examine whether evaluate effects combination paclitaxel....
Altered expression of centromere protein-A (CENP-A) is observed in various types human cancers. However, the clinical significance and pathological role CENP-A epithelial ovarian cancer (EOC) remains unclear. The main objective this investigation was to clarify relationships between clinicopathological features patients with EOC. Real-time quantitative PCR Western blot were performed examine 20 pairs fresh-frozen EOC tissues corresponding noncancerous tissues. Using immunohistochemistry, we...
An ideal carrier that delivers small interfering RNA (siRNA) should be designed based on two criteria: cellular-mediated internalization and endosomal escape. Poly(histidine-arginine)6(H6R6) peptide was introduced into chitosan (CS) to create a new CS derivative for siRNA delivery, 6-polyarginine (R6) as cell-penetrating peptides facilitated nanoparticle cellular has been proved in our previous research, 6-polyhistidine (H6) mediated the endosome escape resulted rapid releasing tumor...
// Lauren A. Baldwin 1,2,* , John T. Hoff Jason Lefringhouse Michael Zhang 1 Changhe Jia Zeyi Liu Sonia Erfani Hongyan Jin Mei Xu Qing-Bai She R. van Nagell 2 Chi Wang Li Chen Rina Plattner David M. Kaetzel 3 Luo Lu 4 Dava West Chunming Fred Ueland Ronny Drapkin 5 Binhua P. Zhou and Xiuwei H. Yang Department of Pharmacology Nutritional Science, Molecular Cellular Biochemistry, Markey Cancer Center, University Kentucky, Lexington, KY Division Gynecologic Oncology, Obstetrics Gynecology,...
Tumor growth and metastasis are the major causes of high mortality in breast cancer. We previously constructed pH-sensitive nanoparticles (D/D NPs) for codelivery docetaxel (DTX) dihydroartemisinin (DHA) demonstrated that D/D NPs showed anticancer activity cancer cells vitro. The present study further investigated therapeutic effect on orthotopic vivo examined antitumor mechanism NPs. significantly increased apoptosis 4T1 with a synergistic DTX DHA. reactive oxygen species, reduced...
Human homeobox gene (HOX) A10 is a allotype of the HOXA family in HOX family. may play an important role cancer development. However, HOXA10 carcinogenesis ovarian clear cell adenocarcinoma (OCCA) has not been established. We have evaluated prognostic significance expression for human OCCA and effects on proliferation, motility, invasion cells. found that was expressed normal epithelium, endometrial cysts, serous carcinomas, but 20 (68.9%) 29 OCCAs were positive HOXA10. negatively correlated...
Recent studies have suggested that FSH plays an important role in ovarian epithelial carcinogenesis. We demonstrated stimulates the proliferation and invasion of cancer cells, inhibits apoptosis facilitates neovascularisation. Our previous work has shown transient receptor potential channel C3 (TRPC3) contributes to progression human cancer. In this study, we further investigated interaction between TRPC3. found stimulation enhanced expression TRPC3 at both mRNA protein levels....
To explore the antiprostate cancer effects of Celastrol on prostate cells' proliferation, apoptosis, and cell cycle distribution, as well correlation to regulation hERG.DU145 cells were treated with various concentrations (0.25-16.0 μmol/L) for 0-72 hours. MTT assay was used evaluate inhibition effect growth DU145 cells. Cell apoptosis detected through both Annexin-V FITC/PI double-labeled cytometry Hoechst 33258. examined by a propidium iodide method. Western blot RT-PCR technologies...
Genistein, the most abundant phytoestrogen in soybeans, may bind to estrogen receptors and perform anticancer activities. Choriocarcinoma is a malignant, trophoblastic aggressive cancer of placenta. Few studies are currently available concerning effects genistein on choriocarcinoma. In present study, we investigated effect invasive potential choriocarcinoma cell line JAR its underlying mechanism. Our data revealed that inhibited invasion dose-dependent manner by matrigel assay. Moreover, was...