A5101742556- Fibroblast Growth Factor Research
- Hedgehog Signaling Pathway Studies
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- MicroRNA in disease regulation
- Developmental Biology and Gene Regulation
- Extracellular vesicles in disease
- Platelet Disorders and Treatments
- Meat and Animal Product Quality
- Metabolomics and Mass Spectrometry Studies
- Cellular transport and secretion
- Proteoglycans and glycosaminoglycans research
- Nerve injury and regeneration
- Cancer Cells and Metastasis
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
Affiliated Hospital of Nantong University
2024-2025
Nantong University
2024-2025
Southwest Medical University
2025
Chengdu University of Technology
2024
Anhui Medical University
2024
Nanjing Medical University
2023
First Hospital of Jilin University
2021-2023
Jilin University
2021-2023
First Affiliated Hospital of Zhengzhou University
2021-2023
Ocean University of China
2020-2022
Ligand-induced down-regulation controls the signaling potency of epidermal growth factor receptor (EGFR/ErbB1). Overexpression studies have identified Cbl-mediated ubiquitinylation EGFR as a mechanism ligand-induced down-regulation. However, role endogenous Cbl in and precise step endocytic pathway regulated by remain unclear. Using Cbl–/– mouse embryonic fibroblast cell lines, we demonstrate that is essential for efficient degradation EGFR. Further analyses using Chinese hamster ovary cells...
ErbB2 overexpression contributes to the evolution of a substantial group human cancers and signifies poor clinical prognosis. Thus, down-regulation signaling has emerged as new anti-cancer strategy. Ubiquitinylation, mediated by Cbl family ubiquitin ligases, physiological mechanism ErbB receptor down-regulation, this appears contribute induced therapeutic anti-ErbB2 antibodies. Hsp90 inhibitory ansamycin antibiotics such geldanamycin (GA) induce rapid ubiquitinylation ErbB2. However,...
Abstract CD151, a master regulator of laminin-binding integrins (α6β4, α6β1, and α3β1), assembles these into complexes called tetraspanin-enriched microdomains. CD151 protein expression is elevated in 31% human breast cancers even more high-grade (40%) estrogen receptor–negative (45%) subtypes. The latter includes triple-negative (estrogen receptor, progesterone HER2 negative) basal-like tumors. ablation markedly reduced mammary cell migration, invasion, spreading, signaling (through FAK,...
Fibroblast growth factor (FGF) 21 is an endocrine actively involved in glucose and lipid metabolism rodents. However, little known about its physiological function regulation humans. This study investigated the diurnal changes circulating FGF21 concentrations their association with other metabolic markers both obese lean individuals.A total of 36 volunteers were assigned to 2 groups. One group received 3 standardized meals another was fasted for 24 h. Blood samples drawn every 30 min...
Aberrant Shh signaling promotes tumor growth in diverse cancers. The importance of is particularly evident medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the pathway component Smoothened (Smo) show great therapeutic promise. However, emergence drug resistance limits long-term efficacy, mechanisms remain poorly understood. Using new models, we identify two distinct paradigms to Smo inhibition. Sufu mutations lead maintenance presence inhibitors. Alternatively...
Resistance to anti-ErbB2 agents is a significant problem in the treatment of human ErbB2+ breast cancers. We show here that adhesion cancer cells basement membrane laminin-5 provides substantial resistance trastuzumab and lapatinib, respectively target extracellular kinase domains ErbB2. Knockdown laminin-binding integrins (alpha6beta4, alpha3beta1) or associated tetraspanin protein CD151 reversed sensitized lapatinib. knockdown, together with treatment, inhibited ErbB2 activation downstream...
Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for it. The tumor microenvironment (TME) in pancreatic cancer, distinguished by fibrosis existence cancer-associated fibroblasts (CAFs), exerts pivotal influence on both advancement resistance to therapy. Recent advancements field engineered extracellular vesicles (EVs) offer novel avenues targeted therapy cancer. This study aimed develop EVs reprogramming...
Significance New effective therapies are desperately needed for lung cancer because most current treatments rarely prevent the metastatic disease that causes majority of patient deaths. We discovered neurotrophin receptor TrkB is an important therapeutic target in using a combination cell line assays, conditional mouse models, and samples.
ErbB2+ human breast cancer is a major clinical problem. Prior results have suggested that tetraspanin CD151 might contribute to ErbB2-driven growth, survival, and metastasis. In other types, sometimes supports tumor growth However, definitive test of effects on de novo initiation, metastasis has not previously been done. We used gene-deleted mice expressing the MMTV-ErbB2 transgene show strongly mammary initiation Delayed onset (by 70-100 days) in absence was accompanied by reduced survival...
// Pengcheng Zhou 1, * , Sonia Erfani 2, Zeyi Liu 3, Changhe Jia 4, Yecang Chen 5, Bingwei Xu 2 Xinyu Deng Jose E. Alfáro 1 Li Dana Napier 6 Michael Lu 8 Jian-An Huang 3 Chunming 7 Olivier Thibault Rosalind Segal Binhua P. Natasha Kyprianou 9 Craig Horbinski 6, # Xiuwei H. Yang Department of Cancer Biology and Pediatric Oncology, Dana-Farber Institute Harvard Medical School, Boston, MA, USA Pharmacology Nutritional Sciences, Markey Center University Kentucky, Lexington, KY, Respiratory...
Sonic hedgehog (Shh) signaling is critical in development and oncogenesis, but the mechanisms regulating this pathway remain unclear. Although protein phosphorylation clearly affects Shh signaling, little known about phosphatases governing pathway. Here, we conducted a small hairpin RNA (shRNA) screen of phosphatome identified Eya1 as positive regulator signaling. We find that catalytically active phosphatase cooperates with DNA-binding Six1 to promote gene induction response Eya1/Six1...
O-GlcNAc transferase (OGT) acts in the development of various cancers, but its role clear cell renal carcinoma (ccRCC) remains unclear. In this study, we found that OGT was upregulated ccRCC and upregulation associated with a worse survival. Moreover, promoted proliferation, clone formation, invasion VHL-mutated cells. Mechanistically, increased protein level hypoxia-inducible factor-2α (HIF-2α) (the main driver phenotype) by repressing ubiquitin‒proteasome system-mediated degradation....
Current myocardial infarction (MI) treatment strategies remain challenged in suboptimal pharmacokinetics and potential adverse effects. Here we present a bioelectronic interface capable of producing on-demand abundant bioactive extracellular vesicles (EVs) near the MI area for in-situ localized treatment. The technology, termed electroactive patch wirelessly controllable EV generation (ePOWER), leverages wireless to stimulate embedded electrosensitive macrophages, actively modulating...
<title>Abstract</title> BACKGROUND Cotton phenol is a yellowish-brown polyphenol hydroxybinaphthyl aldehyde compound mainly found in the roots, stems, leaves and seeds of cotton; plant mallow family that has been widely used study antifertility antitumor drugs. However, there no report serious renal injuries caused by cotton phenol. We case granulomatous acute interstitial nephritis exposure to large amounts CASE DESCRIPTION The patient was 56-year-old male with nausea blood creatinine level...
Cotton phenol is a yellowish-brown polyphenol hydroxybinaphthyl aldehyde compound mainly found in the roots, stems, leaves and seeds of cotton; plant mallow family that has been widely used study antifertility antitumor drugs. However, there no report serious renal injuries caused by cotton phenol. We case granulomatous acute interstitial nephritis exposure to large amounts The patient was 56-year-old male with nausea blood creatinine level 4.95 mg/dL 2 month prior admission. He admitted...
Transcription factor PAX8 expression is upregulated in several types of cancers. However, little known about the function progression hepatoma and its regulatory mechanisms. Here, we show that silencing inhibits proliferation clonogenicity cells growth vivo. The HBV X protein (HBx) does not directly interacts, but stabilizes by inhibiting proteasome-dependent ubiquitination degradation. Furthermore, E3 ubiquitin ligase complex component Skp2 through LRR domain interacts with Prd targets...
Abstract Compelling evidence has indicated the vital role of lysine-specific demethylase 4 A (KDM4A), hypoxia-inducible factor-1α (HIF1α) and mechanistic target rapamycin (mTOR) signaling pathway in nasopharyngeal carcinoma (NPC). Therefore, we aimed to investigate whether KDM4A affects NPC progression by regulating HIF1α/DDIT4/mTOR pathway. First, adjacent tissue samples were collected, protein expression was examined immunohistochemistry. Then, interactions among KDM4A, HIF1α DDIT4...
Abstract Background & Aims Hepatocellular carcinoma (HCC) is one of the leading causes tumour‐related death. Here, we investigated molecular mechanism HCC by studying function circ_GLIS2. Methods Human specimens and cell lines were used. Sanger sequencing, actinomycin D RNase R treatment performed to validate circular RNA features qRT‐PCR, western blotting, immunostaining, IHC employed examine levels circ_GLIS2, GLIS2 mRNA, EMT‐related markers. CCK‐8, colony formation, flow cytometry,...
Objective: Fibroblast growth factor 19 (FGF19) plays an indispensable role in regulating bile acid, glucose and lipid metabolism, alterations of its circulating concentration is associated with the development type 2 diabetes (T2D). Atherosclerosis directly related to death-deriving diabetic macroangiopathy T2D, yet relationships between FGF19 atherosclerosis T2D remain unclear. The aim this study was investigate association levels subclinical (subAS) patients a 3-year prospective study....