A5107975802- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Electroconvulsive Therapy Studies
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Multiple Myeloma Research and Treatments
- Protein Tyrosine Phosphatases
- Hepatitis B Virus Studies
- Prostate Cancer Treatment and Research
- Sepsis Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Peripheral Neuropathies and Disorders
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Renal and Vascular Pathologies
- Renal and related cancers
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Fibroblast Growth Factor Research
- Glioma Diagnosis and Treatment
- Diet, Metabolism, and Disease
Southwest Medical University
2024-2025
University of Macau
2021-2024
University of Nottingham Ningbo China
2023-2024
City University of Macau
2024
First Affiliated Hospital of Chengdu Medical College
2022-2023
Chengdu Medical College
2022
Zhujiang Hospital
2022
Southern Medical University
2022
Affiliated Hospital of Southwest Medical University
2021
North Carolina Central University
2015-2016
Abstract Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy among primary liver cancers, with an increasing overall incidence and poor prognosis. The intertumoral intratumoral heterogeneity of ICC makes it difficult to find efficient drug therapies. Therefore, essential identify tumor suppressor genes oncogenes that induce formation progression. Here, we performed CRISPR/Cas9-mediated genome-wide screening in a liver-specific Smad4/Pten knockout mouse model ( Smad4...
Genistein is a soy isoflavone with phytoestrogen and tyrosine kinase inhibitory properties. High intake of soy/genistein has been associated reduced breast cancer risk. Despite the advances in genistein-mediated antitumor studies, underlying mechanisms remain unclear. In present study, we investigated genistein-induced regulation cancerous inhibitor protein phosphatase 2A (CIP2A), novel oncogene frequently overexpressed cancer, its functional impact on growth inhibition apoptosis. We...
Abstract Fibroblast growth factor receptor 2 (FGFR2) is a membrane‐spanning tyrosine kinase that mediates FGF signaling. Various FGFR2 alterations are detected in breast cancer, yet it remains unclear if activation of signaling initiates tumor formation. In an attempt to answer this question, mouse model berrying mutation (FGFR2‐S252W) the mammary gland generated. It found FGF/FGFR2 drives development triple‐negative cancer accompanied by epithelial‐mesenchymal transition regulated...
Changes in the serum proteome were identified during early, fulminant, and recovery phases of liver injury from acetaminophen rat. Male F344 rats received a single, noninjury dose or high, injury-producing for evaluation at 6 to 120 h. Two-dimensional gel electrophoresis immunodepleted separated approximately 800 stained proteins per sample which differentially expressed by mass spectrometry. Serum alanine aminotransferase/aspartate aminotransferase levels histopathology revealed greatest...
<title>Abstract</title> BACKGROUND Cotton phenol is a yellowish-brown polyphenol hydroxybinaphthyl aldehyde compound mainly found in the roots, stems, leaves and seeds of cotton; plant mallow family that has been widely used study antifertility antitumor drugs. However, there no report serious renal injuries caused by cotton phenol. We case granulomatous acute interstitial nephritis exposure to large amounts CASE DESCRIPTION The patient was 56-year-old male with nausea blood creatinine level...
Cotton phenol is a yellowish-brown polyphenol hydroxybinaphthyl aldehyde compound mainly found in the roots, stems, leaves and seeds of cotton; plant mallow family that has been widely used study antifertility antitumor drugs. However, there no report serious renal injuries caused by cotton phenol. We case granulomatous acute interstitial nephritis exposure to large amounts The patient was 56-year-old male with nausea blood creatinine level 4.95 mg/dL 2 month prior admission. He admitted...
Rapamycin, an anti-proliferative agent, is effective in the treatment of renal cell carcinoma and recurrent breast cancers. We proposed that this potent mammalian target rapamycin inhibitor may be useful for gliomas as well. examined cytotoxicity against a rodent glioma line, determined toxicity when delivered intracranially, investigated efficacy local delivery experimental malignant vivo. also dose-dependent effect locally was combined with radiation therapy. Rapamycin cytotoxic to 9L...
Cholangiocarcinoma (CC), the most lethal type of liver cancer, remains very difficult to treat due an incomplete understanding cancer initiation and progression mechanisms no effective therapeutic drugs.Thus, identification genomic drivers delineation underlying are urgently needed.Here, we conducted a genome-wide CRISPR-Cas9 screening in liver-specific Smad4/Pten knockout mice (Smad4 co/co ;Pten ;Alb-Cre, abbreviated as SPC), identified 15 putative tumor suppressor genes, including Cullin3...
Background Microsatellite instability (MSI), or mismatch repair-deficiency (dMMR), is rare in prostate cancers (PCas). The histological and molecular features of PCas with MSI/dMMR are incompletely described. Thus, we sought to identify the characteristics MSI/dMMR. Methods results We analyzed 1,141 primary treatment-naive by MMR-related protein immunohistochemistry (MLH1, PMS2, MSH2, MSH6). identified eight cases exhibiting (0.7%, 8/1141). Of these, six tumors had both MSH2 MSH6 loss, one...
Rhabdomyolysis (RM) induced by electric blankets is exceedingly rare, with only three cases identified in our literature review. Both RM and Guillain–Barré syndrome (GBS) present similar clinical manifestations of myalgia muscle weakness, posing a potential challenge for accurate diagnosis settings. This report presents the case 22-year-old man who developed subsequent to use an blanket. Despite undergoing plasma exchange renal replacement therapy, patient continued exhibit poor strength...
Abstract Deregulation of erbB-2 and EGFR is frequently detected in breast cancer, which has been associated with poor prognosis. Lapatinib, an orally active small molecule acting as a dual inhibitor EGFR, used for the treatment patients advanced or metastatic erbB-2+ cancer. Lapatinib resistance, however, emerging clinical challenge. Understanding molecular mechanisms Lapatinib-mediated anti-cancer activities identifying relevant resistance factors are pivotal significance cancer treatment....
Abstract The transcriptional profile of PC-3 human prostate cancer cells infected with tumor-targeting Salmonella typhimurium A1-R (A1-R) was analyzed by microarray. is highly sensitive to A1-R. Numerous genes involved in diverse cellular processes, including apoptosis, necrotic cell death, neutrophil chemotaxis and innate immunity were significantly up-regulated bacterial infection. Such include TNF-a, Fos JUN which are death IL-1A CXCL chemotaxes. Knowledge the gene will be exploited for...
Background and Aim. Daphnetin, an active monomer ingredient extracted from D. marginata, is proved to have anti-inflammatory antioxidant effect. The aim of this study explore the effect possible mechanism daphnetin on acute lung injury (ALI) associated with pancreatitis (AP) in mice. Methods. A total 36 mice were randomly assigned into three groups: control group, AP group. mouse model was induced by caerulein lipopolysaccharide. Animals sacrificed at 6 12 h after treatment, respectively....
Background Renal transplantation is a very effective treatment for renal failure patients following kidney transplant. However, the clinical benefit restricted by high incidence of organ rejection. Therefore, there exists wealth literature regarding mechanism transplant rejection, including large library expression data. In recent years, research has shown immune microenvironment to play an important role in Nephrology web analysis tools currently exist address chronic nephropathy, tumors...