A5059658106- Quantum Dots Synthesis And Properties
- Biosensors and Analytical Detection
- Silicone and Siloxane Chemistry
- Advanced biosensing and bioanalysis techniques
- Microbial bioremediation and biosurfactants
- Synthesis and properties of polymers
- Bone Tissue Engineering Materials
- ZnO doping and properties
- Advanced ceramic materials synthesis
- Silk-based biomaterials and applications
- Graphene and Nanomaterials Applications
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Air Quality and Health Impacts
- Photonic Crystals and Applications
- Epoxy Resin Curing Processes
- Cancer Mechanisms and Therapy
- Advanced Cellulose Research Studies
- Flame retardant materials and properties
- MXene and MAX Phase Materials
- Biofuel production and bioconversion
- Advanced Chemical Physics Studies
- Microplastics and Plastic Pollution
- Chemotherapy-related skin toxicity
- Photonic Crystal and Fiber Optics
Zhongyuan University of Technology
2022-2025
Inner Mongolia Medical University
2015-2025
Peking University
2017-2024
Peking University Third Hospital
2024
Capital Medical University
2011-2024
Henan University
2014-2024
Beijing Jishuitan Hospital
2019-2024
China Automotive Technology and Research Center
2024
Harbin Engineering University
2024
Beijing Institute of Neurosurgery
2019-2023
Bone fractures and defects pose serious health-related issues on patients. For clinical therapeutics, synthetic scaffolds have been actively explored to promote critical-sized bone regeneration, electrical stimulations are recognized as an effective auxiliary facilitate the process. Here, we develop a three-dimensional (3D) biomimetic scaffold integrated with thin-film silicon (Si)-based microstructures. This Si-based hybrid not only provides 3D hierarchical structure for guiding cell growth...
This study characterized the occurrence patterns of microplastics (MPs) in bronchoalveolar lavage fluid (BALF) children with pulmonary diseases. MPs were detected 89.6% BALF samples an average 4.31 ± 2.77 items/10 mL, supporting hypothesis that inhalation is a significant pathway airborne MP exposure to pediatric lungs. Inhaled predominantly composed 10 polymer types [e.g., polypropylene (41.9%), polyethylene (19.4%), and polyester (13.6%)], majority being smaller than 20 μm. levels...
The regeneration of critical-size bone defects, especially those with irregular shapes, remains a clinical challenge. Various biomaterials have been developed to enhance regeneration, but the limitations on shape-adaptive capacity, complexity operation, and unsatisfied osteogenic bioactivity greatly restricted their application. In this work, we construct mechanically robust, tailorable water-responsive shape-memory silk fibroin/magnesium (SF/MgO) composite scaffold, which is able quickly...
The selective oxidation of alcohols is widely regarded as one the most important reactions in organic synthesis. Although efficient and environmentally friendly catalysts for alcohol are highly desirable, their development remains an enormous challenge. Metal-organic framework (MOF)-based have demonstrated great potential catalytic remarkably progressed past few decades owing to advantages large surface area, tunable porous structure, abundant accessible active sites, ease reuse recycling....
Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well-known for its roles in regulation of energy homeostasis and glucose metabolism. Here, we show that mice lacking TGR5 were much more susceptible to lipopolysaccharide (LPS)-induced acute gastric inflammation than wild-type (WT) negative regulator through antagonizing NF-κB signaling pathway. We found the treatment ligands 23(S)-mCDCA GPBARA (3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide) suppressed gene...
The latest progress of blue light-emitting diodes based on II–VI semiconductor QDs was reviewed, covering the synthesis QDs, device structures, carrier transport materials, interface regulation, and light outcoupling technology.
Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of genetic factors in tuberculosis (TB) susceptibility. Despite having third highest global TB burden, no TB-related GWAS has been performed China. Here, we first three-stage on Han Chinese population. In stage 1 (discovery stage), after quality control, 691 388 SNPs present 972 patients and 1537 controls were retained. After replication an additional 3460 4862 (stages 2 3), identified three significant loci...
Abstract The farnesoid X receptor (FXR) is a key metabolic and homeostatic regulator in the liver. In present work, we identify novel role of FXR antagonizing c-Jun N-terminal kinase (JNK) signaling pathway liver carcinogenesis by activating superoxide dismutase 3 (SOD3) transcription. Compared with wild-type mouse liver, FXR−/− showed elevated JNK phosphorylation. JNK1 deletion suppressed increase diethylnitrosamine-induced tumor number mice. These results suggest that plays...
A comparative experimental and numerical study of the impact behaviour carbon-fiber-reinforced thermoplastic (TP) thermoset (TS) composites has been carried out. On one hand, low velocity (LVI) tests were performed on TP TS with different lay-up sequences at energy levels, damage modes microscopic mechanisms after investigated using macroscale inspection, C-scan X-ray-computed tomography. The results show that initial valve force under LVI depends not only material, but also layup sequence....
// Jia Su 1, * , Qiqi Zhang Hui Qi 2, Linlin Wu 1 Yuanqiang Li Donna Yu 4 Wendong Huang Wei-Dong Chen 3 and Yan-Dong Wang State Key Laboratory of Chemical Resource Engineering, College Life Science Technology, Beijing University Beijing, P.R. China 2 Receptors-Mediated Gene Regulation Drug Discovery, School Medicine, Henan University, Kaifeng, Henan, Molecular Pathology, Basic Medical Science, Inner Mongolia Hohhot, Mongolia, Department Diabetes Metabolic Diseases Research, Beckman Research...
CCR4 is highly expressed on Th2 cells. ligands include CCL22 and CCL17. Chemokine-like factor 1 can also mediate chemotaxis via CCR4. We designed synthetized novel antagonists, which were piperazinyl pyridine derivatives, for disrupting the interaction between three determined whether these antagonists could alleviate allergic asthma in a mouse. For identifying potent compounds vitro, we used inhibition competition binding assays induced by CCL22, CCL17 one of CKLF1's C-terminal peptides,...
Abstract Breaking the theoretical limits of external quantum efficiency (EQE) and obtaining dot light‐emitting diodes (QLEDs) with high brightness, efficiency, low operating voltage is basis commercial applications in display illumination. Devices an EQE over 20% can be realized by carrier equilibrium injection light out‐coupling enhancement. However, it difficult to synergistically enhance performance QLEDs combining hole enhancement injection. In this paper, holes are simultaneously only...
Enhancing light outcoupling in quantum dot light‐emitting diodes (QLEDs) is one of the most important tasks to boost external efficiency (EQE); this improvement crucial for advancing fields illumination and displays. Herein, multilevel wrinkle structure with richer Fourier spectra has been fabricated, such structures possess advantages increasing scattering decreasing reflection. A strategy utilizing a demonstrated achieve spectrally independent green QLEDs. The device shows maximum EQE...
Tripartite motif-containing 44 (TRIM44) involves in various tumor development. This study investigated role of TRIM44 multiple myeloma (MM). levels bone marrow tissues and MM cell lines was detected by quantitative reverse transcription PCR (RT-qPCR). Cell viability, migration, invasion cells were evaluated under the interference expression. The on regulating growth vivo also subcutaneous xenograft models. protein interact between Zinc Finger E-Box Binding Homeobox 1 (ZEB1) studied according...
Chronic inflammation is increasingly recognized as an important component of tumorigenesis and metabolic diseases. The roles microRNA149* (miRNA149*) in remain poorly understood. Here, we demonstrate that miR-149* a suppressor STAT3-mediated inflammation. MiR-149*-/- mice were generated with CRISPR/CAS9 technique. In lipopolysaccharide (LPS)-induced model, miR-149*-/- show more severe liver injury inflammation, compared wild-type (WT) mice. also displayed elevated messenger RNA (mRNA) levels...
Although titanium (Ti) and Ti-based alloy have been widely used as dental orthopedic implant materials, its bioinertness hindered the rapid osseointegration. Therefore, it is recommended to acquire ideal topographic chemical characteristics through surface modification methods. 3D printing a delicate manufacture technique which possesses superior controllability reproducibility. While aspirin serve well-established non-steroidal anti-inflammatory agent. Recently, importance of immune system...
Dihydroartemisinin (DHA), a semisynthetic derivative of artemisinin isolated from the traditional Chinese herb Artemisia annua, is an effective novel antimalarial drug. Recent studies suggest that it also has anticancer effects. The present study investigated apoptosis activity DHA in cultured human lung cancer cells by terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) assay and flow cytometry. Intracellular free calcium concentrations were evaluated laser scanning...
Surface coating modification of titanium-based alloys is an efficient way to accelerate early osseointegration in dental implant fields. Icariin (ICA) a traditional Chinese medicine that has bone activating functions, while aspirin (ASP) classical non-steroidal anti-inflammatory drug with good antipyretic and analgesic capabilities. Moreover, poly(lactic–co–glycolic acid) (PLGA) attracted great attention due its excellent biocompatibility biodegradability. We superimposed ASP/PLGA onto ICA...
As the information available on treatment of angiostrongyliasis with a combination albendazole and dexamethasone is limited, efficacy such therapy was assessed using data collected during 2006 outbreak in Beijing. In retrospective controlled study, 35 patients treated albendazole–dexamethasone (given 20 mg albendazole/kg 3 daily for 7 days) were compared 34 controls who only symptomatically (with acetaminophen or other drugs). Compared controls, given less likely to have headaches after days...
Improving the light extraction efficiency by introducing optical-functional structures outside of quantum dot emitting diodes (QLEDs) for further enhancing external (EQE) is essential their application in display and lighting industries. Although QLEDs has been optimized controlling synthesis dots, low outcoupling indeed unresolved because total internal reflections, waveguides metal surface absorptions within device. Here, we utilize multiscale nanostructures attached to outer glass...
Quasi-periodic wrinkles are successfully used as a diffraction grating for extracting trapped light at the substrate/air interface, which can be adjusted from nano-scale to micron-scale, optimized wrinkle device shows peak EQE of 15.41%.