A5064634628- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Liver physiology and pathology
- Supramolecular Self-Assembly in Materials
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Probiotics and Fermented Foods
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Advanced biosensing and bioanalysis techniques
- Liver Diseases and Immunity
- Phagocytosis and Immune Regulation
- Drug-Induced Hepatotoxicity and Protection
- Cell death mechanisms and regulation
- Polydiacetylene-based materials and applications
- Pharmacological Effects of Natural Compounds
- 3D Printing in Biomedical Research
- Cystic Fibrosis Research Advances
- Metabolomics and Mass Spectrometry Studies
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
Zhejiang Chinese Medical University
2020-2025
Xiangya Hospital Central South University
2025
Central South University
2025
Southwest Medical University
2019-2024
Soochow University
2024
Okayama University
2024
Zhengzhou University
2022-2023
Osaka University
2023
Shantou University
2023
Shantou University Medical College
2023
Abstract Synthetic biology based on bacteria has been displayed in antitumor therapy and shown good performance. In this study, an engineered bacterium Escherichia coli MG1655 is designed with NDH‐2 enzyme (respiratory chain II) overexpression (Ec‐pE), which can colonize tumor regions increase localized H 2 O generation. Following from this, magnetic Fe 3 4 nanoparticles are covalently linked to act as a catalyst for Fenton‐like reaction, converts toxic hydroxyl radicals (•OH) therapy....
Abstract In this paper, a simple, but effective method is reported to construct the core−shell gold nanorod@metal–organic frameworks (AuNR@MOFs) as multifunctional theranostic platform by using functionalized AuNRs seed crystal for growth of porphyrinic MOFs on surface AuNR. Such delicate tunable composite not only possesses improved drug loading efficiency, near‐infrared light‐trigger release, and fluorescence imaging, also can produce reactive oxygen species well photothermal activity...
The delivery of probiotics to the microbiota is a promising method prevent and treat diseases. However, oral will suffer from gastrointestinal insults, especially pathological microenvironment inflammatory diseases such as reactive oxygen species (ROS) exhausted mucus layer, which can limit their survival colonization in intestinal tract. Inspired by fact that colonized grew layer under physiological conditions, we developed strategy for super probiotic (EcN@TA-Ca2+@Mucin) coated with tannic...
Abstract Therapeutic approaches that reprogram the gut microbiome are promising strategies to alleviate and cure inflammatory bowel disease (IBD). However, abnormal expansion of Escherichia coli during inflammation can promote pathogenic bacteria occupying ecological niches resist reprogramming microbiome. Herein, a bionic regulator (CaWO 4 @YCW) is developed efficiently precisely regulate by specifically suppressing E. colitis boosting probiotic growth. Inspired binding strains mannose‐rich...
The effective delivery and colonization of probiotics are recommended for therapeutic interventions during colitis, the efficacy which is hampered by abnormally colonized Enterobacteriaceae at pathological sites. To improve probiotics, a calcium tungstate microgel (CTM)-based oral probiotic system proposed herein. CTM can selectively disrupt ecological niche occupied expanded colitis to facilitate colonization. In addition, calcium-binding protein, calprotectin, highly expressed in...
ABSTRACT Saikosaponin b1 (Ssb1), a natural oleanane‐type triterpenoid saponin, exhibits antifibrosis activity by inhibiting the activation of hepatic stellate cells (HSCs), but specific underlying molecular mechanisms are unknown. Here, it is found that Ssb1 could directly bind with signal transducer and activator transcription 3 (STAT3) effectively inhibit HSCs. Proteomic techniques simulation revealed mainly bound to S319 residues STAT3 in coiled‐coil domain. Further studies indicated...
A multifunctional nanosystem based on two-dimensional molybdenum disulfide (MoS2) was developed for synergistic tumor therapy. MoS2 stabilized with lipoic acid (LA)-modified poly(ethylene glycol) and modified a pH-responsive charge-convertible peptide (LA-K11(DMA)). Then, positively charged photosensitizer, toluidine blue O (TBO), loaded via physical absorption. The negatively LA-K11(DMA) converted into one under acidic conditions. Charge conversion of the could reduce binding force between...
Free radicals have emerged as new-type and promising candidates for hypoxic tumor treatment, further study of their therapeutic mechanism by real-time imaging is great importance to explore biomedical applications. Herein, we present a smart free-radical generator AuNC-V057-TPP therapy; the not only exhibits good effect under both normoxic conditions but also can monitor release free in vitro vivo. What more, with mitochondria-targeting ability, demonstrated improved antitumor efficacy...
Liver fibrosis and hepatocellular carcinoma (HCC) have been worldwide threats nowadays. is reversible in early stages but will develop precancerosis of HCC cirrhotic stage. In pathological liver, excessive H2O2 generated accumulated, which impacts the functionality hepatocytes, Kupffer cells (KCs) hepatic stellate (HSCs), leading to genesis HCC. accumulation associated with overproduction superoxide anion (O2•-) abolished antioxidant enzyme systems. Plenty therapeutics focused on shown...
Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves wide range content, along with high requirements for doctor's professionalism multi-specialty teamwork, as well great demand time-sensitive treatments. However, this not matched care professionals current state medical in China. Telemedicine, which shortens distance gap disease diagnosis treatments regions through...
Abstract Hypoxia and hydrogen peroxide (H 2 O ) accumulation form the profibrogenic liver environment, which involves fibrogenesis chronic stimulation of hepatic stellate cells (HSCs). Catalase (CAT) is major antioxidant enzyme that catalyzes H into oxygen water, loses its activity in different diseases, especially fibrosis. Clinical specimens cirrhosis patients fibrotic mice are collected this work, results show CAT decrease closely correlated with hypoxia-induced transforminmg growth...
A programmed pre-targeting system for tumor cell imaging and targeting therapy was established based on the "biotin–avidin" interaction. In this functional system, transferrin-biotin can be actively captured by cells with overexpression of transferrin receptors, thus achieving modality. Depending upon avidin–biotin recognition, attachment multivalent FITC–avidin to biotinylated not only offered rapid fluorescence labelling, but also endowed pre-targeted sites specifically designed peptide...
Camptothecin (CPT)-based drugs always undergo the reversible, pH-dependent lactone ring-opening reaction, yielding inactive but toxic carboxylate form. Self-assembly strategy provides an effective route for preserving their bio-stability. In this article, nano-sized self-assemblies from CPT-based antitumor were simply built up by directly diluting stock dimethylsulfoxide solutions of (S)-(+)-CPT, (S)-10-hydroxyl camptothecin and carboxylic CPT with water/phosphate-buffered saline solution....