A5100712523- Probiotics and Fermented Foods
- Gut microbiota and health
- Nanoplatforms for cancer theranostics
- Advanced Materials and Mechanics
- Liquid Crystal Research Advancements
- Infant Nutrition and Health
- Micro and Nano Robotics
- Advanced Nanomaterials in Catalysis
- Advanced Cellulose Research Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Marine Bivalve and Aquaculture Studies
- Advanced biosensing and bioanalysis techniques
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Luminescence and Fluorescent Materials
- Echinoderm biology and ecology
- Photodynamic Therapy Research Studies
- 3D Printing in Biomedical Research
- Insect and Pesticide Research
- Escherichia coli research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Fungal Biology and Applications
- interferon and immune responses
- Ocean Acidification Effects and Responses
- Antibiotic Resistance in Bacteria
Shanghai Xuhui Central Hospital
2023-2024
Fudan University
2022-2024
Nankai University
2024
Zhengzhou University
2022-2023
Shandong Agricultural University
2023
New Technology (Israel)
2023
ZheJiang Academy of Agricultural Sciences
2023
Hunan Normal University
2021
Chinese Academy of Sciences
2018-2019
University of Chinese Academy of Sciences
2018-2019
The delivery of probiotics to the microbiota is a promising method prevent and treat diseases. However, oral will suffer from gastrointestinal insults, especially pathological microenvironment inflammatory diseases such as reactive oxygen species (ROS) exhausted mucus layer, which can limit their survival colonization in intestinal tract. Inspired by fact that colonized grew layer under physiological conditions, we developed strategy for super probiotic (EcN@TA-Ca2+@Mucin) coated with tannic...
Oral drug delivery is a common route for management of inflammatory bowel disease (IBD) but suffers from low bioavailability and systemic side effects during passage through the alimentary canal. Here, we present therapeutic nano reagent ferulic acid-derived lignin nanoparticle (FALNP). We showed that FALNP with favorable antioxidant activity can regulate IBD. More importantly, intestinal pH-responsive degradability allows it to withstand harsh gastric acid environment, bypass physiological...
Abstract Therapeutic approaches that reprogram the gut microbiome are promising strategies to alleviate and cure inflammatory bowel disease (IBD). However, abnormal expansion of Escherichia coli during inflammation can promote pathogenic bacteria occupying ecological niches resist reprogramming microbiome. Herein, a bionic regulator (CaWO 4 @YCW) is developed efficiently precisely regulate by specifically suppressing E. colitis boosting probiotic growth. Inspired binding strains mannose‐rich...
Free radical therapy based on 5-aminolevulinic acid (ALA, a precursor of the photosensitizer protoporphyrin IX (PpIX)) has been approved by US Food and Drug Administration for clinical tumor treatment. However, PpIX can be quickly converted into photoinactive heme, leading to unexpectedly paused production free radicals severely hindering its therapeutic benefits. Here, inspired natural biotransformation ALA (ALA-PpIX-heme), an uninterrupted reactive oxygen species generator (URG) that...
Mitochondria-specific photosensitizer accumulation is highly recommended for photodynamic therapy and mitochondrial DNA (mtDNA) oxidative damage-based innate immunotherapy but remains challenging. 5-Aminolevulinic acid (ALA), precursor of protoporphyrin IX (PpIX), can induce the exclusive biosynthesis PpIX in mitochondria. Nevertheless, its effect limited by intracellular biotransformation ALA tumors. Here, we report a metabolism-regulating strategy using ALA/DNAzyme-co-loaded nanoparticles...
Construction of biomimetic models for structural color evolution not only gives new photonic phenomena but also provide cues biological morphogenesis. Here, a novel confined self-assembly method is proposed the generation hydroxypropyl cellulose (HPC)-based cholesteric liquid crystals (CLCs) microbubbles. The assembly process relies on combination droplet microfluidics, solvent extraction, and volume environment. as-prepared HPC microbubbles have transparent shell, an orderly arranged...
Early weaning in piglets can cause a series of negative effects. This causes serious losses to the livestock industry. N-Acetyl-D-glucosamine (D-GlcNAc) plays an important role regulating homeostasis intestine. study aimed investigate effects D-GlcNAc on growth performance and intestinal function weaned piglets. Twenty-four ([Yorkshire × Landrace] Duroc, 6.58 ± 0.15 kg, n = 8) at 21 d old were fed 3 diets supplemented with 0 (control), 1 g/kg D-GlcNAc. The organoid model was used verify...
Polymer fibers are attracting increasing attention as a type of fundamental material for wide range products. However, to incorporate novel functionality, crucial challenge is simultaneously manipulate their structuring across multiple length scales. In this research, facile and universal approach proposed by directly drawing pre-gel feedstock embedding cellulose cholesteric liquid crystal (CLC). An in situ photo-polymerization process applied, which not only allows the continuous filaments...
Enterohemorrhagic Escherichia coli (EHEC) is an important foodborne pathogen that infects humans by colonizing the large intestine. The genome of EHEC O157:H7 contains 177 unique O islands (OIs). Certain OIs significantly contribute to heightened virulence and pathogenicity exhibited O157:H7. However, function most OI genes remains unknown. We demonstrated here adherence colonization mouse intestine are both dependent on OI-97. Z3495, which annotated as a LysR-type transcriptional regulator...
Colored contact lenses have gained popularity among young individuals owing to their ability alter the appearance of wearer's eyes. However, conventional containing chemical dyes are susceptible detachment pigment layer, which can lead corneal damage. In this research, a novel cellulose-based structural color lens (SCCL) is presented that enhances aesthetic appeal via cholesteric liquid crystal (CLC) layer. Methacrylate-functionalized hydroxypropyl cellulose (HPCMA) molecules self-assemble...
Antibiotic residues and antibiotic resistance genes (ARGs) in fruits vegetables pose public health risks via the food chain with increased attention. Antibiotics such as streptomycin are used directly for grapes seedless or enter vineyard soil through organic fertilizers. However, extensive data to support risk assessment of remains lacking. We metagenomic sequencing characterize resistome mobile genetic elements (MGEs) Shine Muscat grape. Abundant MGEs ARGs were found (174 on grape surface...