A5074784021- Echinoderm biology and ecology
- Marine Bivalve and Aquaculture Studies
- Ocean Acidification Effects and Responses
- Invertebrate Immune Response Mechanisms
- Aquatic life and conservation
- Coral and Marine Ecosystems Studies
- Marine Biology and Environmental Chemistry
- Aquaculture disease management and microbiota
- Seaweed-derived Bioactive Compounds
- Physiological and biochemical adaptations
- Cell death mechanisms and regulation
- Aquaculture Nutrition and Growth
- Gut microbiota and health
- Marine Sponges and Natural Products
- Marine and coastal plant biology
- Spacecraft and Cryogenic Technologies
- Endometrial and Cervical Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- Extracellular vesicles in disease
- Cardiac tumors and thrombi
- ATP Synthase and ATPases Research
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
South China Sea Institute Of Oceanology
2017-2024
Institute of Oceanology
2017-2024
Chinese Academy of Sciences
2017-2024
Qingdao National Laboratory for Marine Science and Technology
2017-2024
Marine Biology Institute of Shandong Province
2021-2024
Shenzhen Institutes of Advanced Technology
2024
University of Chinese Academy of Sciences
2017-2024
Cornell University
2022-2024
Weifang People's Hospital
2020-2024
Boston University
2021
Abstract Embryonic stem cell (ESC)-derived epitopes can act as therapeutic tumor vaccines against different types of tumors Jin (Adv Healthc Mater 2023). However, these have poor immunogenicity and stimulate insufficient CD8 + T responses, which motivated us to develop a new method deliver enhance their effectiveness. Bacterial outer membrane vesicles (OMVs) serve immunoadjuvants delivery vector for antigens. In the current study, we engineered OMV platform co-delivery ESC-derived antigens...
Hypoxia is one of the most frequently occurring stressors confronted by industrial cultures sea cucumber and can cause large economic losses resource degradation. However, its responsive mechanisms are still lacking. In this paper, physiological responses Apostichopus japonicus to oxygen deficiency was illustrated, including induced oxidative response immune defense changed digestive enzymes activities. Significantly increased activities alpha-amylase (AMS), acid phosphatase (ACP), lactate...
The Pacific white shrimp (Litopenaeus vannamei) is an important cultured crustacean species worldwide. However, little known about the molecular mechanism of this involved in response to cold stress. In study, four separate RNA-Seq libraries L. vannamei were generated from 13°C stress and control temperature. Total 29,662 Unigenes overall 19,619 annotated genes obtained. Three comparisons carried out among libraries, which 72 top 20% differentially-expressed obtained, 15 GO 5 KEGG...
Abstract Low dissolved oxygen (LO) conditions represent a major environmental challenge to marine life, especially benthic animals. For these organisms, drastic declines in availability (hypoxic events) can trigger mass mortality events and thus, act as agents of selection influencing the evolution adaptations. In sea cucumbers, one most successful groups invertebrates, exposure hypoxic triggers adaptive adjustments metabolic rates behaviour. It is unclear, however, how responses are...
The sea cucumber, an important economic species, has encountered high mortality since 2013 in northern China because of seasonal environmental stress such as hypoxia, temperature, and low salinity. MicroRNAs (miRNAs) are regulating gene expression marine organisms response to change. In this study, high-throughput sequencing was used investigate alterations miRNA the cucumber under different levels dissolved oxygen (DO). Nine small RNA libraries were constructed from respiratory trees. A...
The optimal chemotherapy-free regimens for treatment-naive CLL still remains undefined. We searched relevant published reports. Three trials with 1017 subjects were identified. In the network meta-analysis, acalabrutinib plus obinutuzumab (Aca + Obi) improved PFS than ibrutinib (Ibu (HR:0.43, p = .02) and venetoclax (Ven (HR:0.30, < .001) as IRC assessment. Sensitivity analysis of investigator assessment also showed Aca Obi Ibu (HR:0.46, .04) Ven (HR:0.34, .002). Among these first-line...
Abstract Background The sea cucumber Holothuria leucospilota belongs to echinoderm, which is evolutionally the most primitive group of deuterostomes. Sea has a cavity between its digestive tract and body wall that filled with fluid suspended coelomic cells similar blood cells. humoral immune response based on secretion various factors from coelomocytes into cavity. aim this study lay out foundation for mechanisms in echinoderms their origins chordates by using RNA-seq. Results primary were...
Sea cucumbers are predominant deposit feeders in benthic ecosystems, providing protective benefits to coral reefs by reducing disease prevalence. However, how they receive sufficient nutrition from seabed sediments remains poorly understood. Here, we investigate Holothuria leucospilota, an ecologically significant tropical sea cucumber, elucidate digestive mechanisms underlying marine deposit-feeding. Genomic analysis reveals intriguing evolutionary adaptation characterized expansion of...
Genetic linkage maps have become an indispensable tool for genetics and genomics research. Sea cucumber (Apostichopus japonicus), which is economically important mariculture species in Asia, edible echinoderm with medicinal properties. In this study, the first SNP-based high-density genetic map was constructed by sequencing 132 A. japonicus individuals (2 parents 130 offspring) according to a genotyping-by-sequencing (GBS) method. The consensus 3181.54 cM long, average distance of 0.52 cM. A...