A5013082890- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Hip disorders and treatments
- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Bone health and treatments
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Gut microbiota and health
- Mesenchymal stem cell research
- Image and Signal Denoising Methods
- Virus-based gene therapy research
- Cancer Research and Treatments
- Cancer-related gene regulation
- Occupational and environmental lung diseases
- Biochemical Acid Research Studies
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Maritime Navigation and Safety
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
First Affiliated Hospital of Zhengzhou University
2021-2025
Second Affiliated Hospital of Jilin University
2014-2024
First People's Hospital of Kunshan
2014-2024
Zhengzhou University
2019-2024
Qingdao Binhai University
2024
Jiangsu University
2014-2024
Zhejiang Normal University
2023
State Key Laboratory of Respiratory Disease
2023
Guangzhou Medical University
2023
First Affiliated Hospital of Guangzhou Medical University
2023
Abstract Thymic stromal lymphopoietin (TSLP) is said to increase expression of chemokines attracting Th2 T cells. We hypothesized that asthma characterized by elevated bronchial mucosal TSLP and Th2-attracting, but not Th1-attracting, as compared with controls, selective accumulation cells bearing receptors for these chemokines. used in situ hybridization immunohistochemistry examine the cellular provenance TSLP, Th2-attracting (thymus activation-regulated chemokine (TARC)/CCL17,...
Abstract Asthma and chronic obstructive pulmonary disease (COPD) are associated with Th2 Th1 differentiated T cells. The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of cells secretion chemokines which preferentially attract them. We hypothesized that there is distinct airways expression TSLP Th1- Th2-type cells, influx bearing their receptors in asthma COPD. In situ hybridization, immunohistochemistry, ELISA were used to examine the cellular provenance TSLP,...
The delivery of probiotics to the microbiota is a promising method prevent and treat diseases. However, oral will suffer from gastrointestinal insults, especially pathological microenvironment inflammatory diseases such as reactive oxygen species (ROS) exhausted mucus layer, which can limit their survival colonization in intestinal tract. Inspired by fact that colonized grew layer under physiological conditions, we developed strategy for super probiotic (EcN@TA-Ca2+@Mucin) coated with tannic...
Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as calcium-activated chloride channel (CaCC) reported be overexpressed several malignancies; however, its expression function (CRC) remains unclear. In this study, we found of mRNA protein high-metastatic-potential SW620, HCT116 LS174T cells, but not primary HCT8 SW480 using RT-PCR, western blotting...
Steroid-induced osteonecrosis of the femoral head (SONFH) is a common debilitating orthopedic disease. The bone marrow mesenchymal stem cells (BMSCs) are type which play crucial roles in repair. adipogenic/osteogenic differentiation disorder BMSCs has been widely perceived contributing to SONFH. However, regulatory mechanism still remains unclear. Circular RNA (circRNA), kind stable ncRNA, plays important regulating gene expression via various ways. To date, there no studies uncover circRNA...
Abstract Objectives To compare the effectiveness and safety between autologous platelet‐rich plasma ( PRP ) Local Anesthetic (LA) /corticosteroid in intra‐articular injection for treatment of lumbar facet joint syndrome. Methods Forty‐six eligible patients with syndrome were randomized into group A (intra‐articular B LA /corticosteroid). The following contents evaluated: pain visual analog scale VAS at rest during flexion, Roland‐Morris Disability Questionnaire RMQ ), Oswestry Index ODI...
Abstract Therapeutic approaches that reprogram the gut microbiome are promising strategies to alleviate and cure inflammatory bowel disease (IBD). However, abnormal expansion of Escherichia coli during inflammation can promote pathogenic bacteria occupying ecological niches resist reprogramming microbiome. Herein, a bionic regulator (CaWO 4 @YCW) is developed efficiently precisely regulate by specifically suppressing E. colitis boosting probiotic growth. Inspired binding strains mannose‐rich...
Abstract The modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation progression various tumor types. However, precise role potential mechanism Y‐box‐binding protein 1 (YBX1) esophageal squamous cell carcinoma (ESCC) remains unclear. Here, it is found that YBX1 frequently upregulated ESCC compared with matched nontumor tissues. Gain‐ loss‐of‐function assays show promoted proliferation metastasis cells both vitro vivo. Functional studies revealed NOP2/Sun RNA...
Abstract Hepatic encephalopathy (HE) is a neurological disease occurring in patients with hepatic insufficiency and/or portal-systemic blood shunting based on cirrhosis. The pathogenesis not completely clear till now, but it believed that hyperammonemia the core of HE. Hyperammonemia caused by increased sources ammonia and decreased metabolism further causes mental problems through gut–liver–brain axis. vagal pathway also plays bidirectional role Intestinal microorganisms play an important...
Abstract NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), posttranscriptional modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function pancreatic cancer (PC) needs to be elucidated. Herein, we determined that was overexpressed PC tissues and related aggressive clinical features. Silence by lentivirus weakened capability proliferation, migration invasion cells vitro inhibited growth...
Background: The purpose of this study was to test the hypothesis that periodontal pathogens associated with aggressive periodontitis persist in extracrevicular locations following scaling and root planing, systemic antibiotics, antimicrobial rinses. Methods: Eighteen patients received a clinical examination during which samples subgingival plaque buccal epithelial cells were obtained. Treatment consisted full‐mouth chlorhexidine Clinical measurements sampling repeated at 3 6 months....
Long noncoding RNAs (lncRNAs) are critical gene expression regulators and involved in several bone diseases. To explore the potential roles of lncRNAs osteonecrosis femoral head (ONFH), we investigated for first time lncRNA profile marrow mesenchymal stem cells (BMSCs) from patients with steroid-induced ONFH (SONFH) microarray bioinformatics analysis. A total 1878 838 mRNAs were significantly up-regulated while 1842 1937 statistically down-regulated SONFH group compared control group. The...
BACKGROUND:Globally, gastric cancer (GC) is the third most common source of cancer-associated mortality. The aim this study was to identify key genes and circular RNAs (circRNAs) in GC diagnosis, prognosis, therapy further explore potential molecular mechanisms GC. MATERIAL AND METHODS:Differentially expressed (DEGs) circRNAs (DE circRNAs) between tissues adjacent non-tumor were identified from 3 mRNA circRNA expression profiles. Functional analyses performed, protein–protein interaction...
Background: Hepatocellular carcinoma (HCC) is a common malignancy with high mortality worldwide. Despite advancements in diagnosis and treatment recent years, there still an urgent unmet need to explore the underlying mechanisms novel prognostic markers. Anoikis has received considerable attention because of its involvement progression human malignancies. However, potential mechanism anoikis-related genes (ANRGs) HCC remains unclear. Methods: We use comprehensive bioinformatics analyses...