A5100759964- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Liver physiology and pathology
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone health and treatments
- Gastric Cancer Management and Outcomes
- Cloud Computing and Resource Management
- Face Recognition and Perception
- Mesenchymal stem cell research
- SARS-CoV-2 detection and testing
- Genetic factors in colorectal cancer
- Electrospun Nanofibers in Biomedical Applications
- Education and Islamic Studies
Beihang University
2023-2025
Shanghai Jiao Tong University
2021-2025
Tianjin Medical University
2022-2025
Sichuan University
2017-2024
Bengbu Medical College
2024
University of South China
2024
Chenzhou First People's Hospital
2024
Wuhan University
2023-2024
Renmin Hospital of Wuhan University
2023-2024
University of Southampton
2023
Abstract Purpose: Immune checkpoint inhibitors (ICI) have revolutionized cancer management. However, molecular determinants of response to ICIs remain incompletely understood. Experimental Design: We performed genomic profiling 78 patients with non–small cell lung (NSCLC) who underwent anti–PD-(L)1 therapies by both whole-exome and targeted next-generation sequencing (a 422-cancer-gene panel) explore the predictive biomarkers ICI response. Tumor mutation burden (TMB), specific somatic...
Serverless computing is increasingly being used for parallel computing, which have traditionally been implemented as stateful applications. Executing complex, burst-parallel, directed acyclic graph (DAG) jobs poses a major challenge serverless execution frameworks, will need to rapidly scale and schedule tasks at high throughput, while minimizing data movement across tasks. We demonstrate that, computations, decentralized scheduling enables be distributed Lambda executors that can in...
Alkaline environments such as alkaline lands, lakes, and industrial wastewater are not conducive to the growth of plants microorganisms due high pH salinity. ChbZIP1 is a bZIP family transcription factor isolated from an alkaliphilic microalgae (Chlorella sp. BLD). Previous studies have demonstrated its ability enhance tolerance in Arabidopsis thaliana. However, potential confer similar other remains unclear, specific mechanisms fully understood. The analysis cellular physiological...
Periodontal tissue regeneration is a major challenge in engineering due to its regenerated environment complexity. It aims regenerate not only the supporting alveolar bone and cementum around teeth but also key connecting periodontal ligament. Herein, constructed aligned porous hydrogel scaffold carrying cells based on chitosan (CHI) oxidized chondroitin sulfate (OCS) treated with freeze-casting technique was fabricated, which aimed induce arrangement of regeneration. The microscopic...
Long noncoding RNAs (lncRNAs) are critical gene expression regulators and involved in several bone diseases. To explore the potential roles of lncRNAs osteonecrosis femoral head (ONFH), we investigated for first time lncRNA profile marrow mesenchymal stem cells (BMSCs) from patients with steroid-induced ONFH (SONFH) microarray bioinformatics analysis. A total 1878 838 mRNAs were significantly up-regulated while 1842 1937 statistically down-regulated SONFH group compared control group. The...
Live poultry markets are a source of human infection with avian influenza A (H7N9) virus. On February 21, 2014, farmer infected H7N9 virus was identified in Jilin, China and H9N2 viruses were isolated from the patient's farm. Reassortment between these subtype generated five genotypes, one which caused infection. The date introduction to farm is estimated be August 2013 (95% confidence interval [CI] June 6, 2013-October 2013) September 25, CI May 28, 2013-January 4, 2014), suggesting that...
Papillary thyroid carcinoma (PTC) is the most common malignancy of gland, with a relatively high cure rate. Distant metastasis (DM) PTC uncommon, but when it occurs, significantly decreases survival patients. The molecular mechanisms DM in have not been systematically studied. We performed whole exome sequencing and GeneseeqPrime (425 genes) panel primary tumor, plasma matched white blood cell samples from 20 46 without DM. identified somatic mutations, gene fusions copy number alterations...
Abstract Single‐cell arrays have emerged as a versatile method for executing single‐cell manipulations across an array of biological applications. In this paper, innovative microfluidic platform is unveiled that utilizes optoelectronic tweezers (OETs) to and sort individual cells at flow rate 20 µL min −1 . This also adept dielectrophoresis (DEP)‐based, light‐guided retrievals from designated micro‐wells. presents compelling non‐contact the rapid straightforward sorting are hard distinguish....
Macrophage infiltration and activation is a critical step during acute pancreatitis (AP). NLRP3 inflammasomes in macrophages plays role mediating pancreatic inflammatory responses. Qing-Yi Decoction(QYD)has been used for many years clinical practice of Nankai Hospital combined with traditional Chinese western medicine treatment pancreatitis. Although QYD has well-established efficacy, little known about its bioactive ingredients, how they interact different therapeutic targets the pathways...
BACKGROUND Steroid-induced osteonecrosis of the femoral head (SONFH) is a common orthopedic disease associated with application glucocorticoid (GC). In this study, we detected microRNAs (miRNAs) differentially expressed in bone marrow mesenchymal stem cells (BMSCs) from SONFH patients, and target gene predictions were performed, functions genes was verified. MATERIAL AND METHODS BMSCs collected patients neck fracture (FNF) constituted group (n=3) FNF (control) (n=3), respectively. MiRNA...
Background Anti-programmed death (PD)-1 therapy has recently been used in recurrent or metastatic (R/M) nasopharyngeal carcinoma (NPC). The long-term survival and its biomarkers responding to anti-PD-1 treatment patients with R/M NPC remain unclear. Methods Patients were enrolled between March 2016 January 2018 from two phase I clinical trials. median follow-up period was 24.7 months. Eligible progressed on standard chemotherapy had measurable disease by Response Evaluation Criteria Solid...
Abstract The incidence of melanoma is rising globally including China. Comparing to Caucasians, the non‐cutaneous melanomas significantly higher in Chinese. Herein, we performed genomic profiling 89 Chinese surgically resected primary melanomas, acral ( n = 54), cutaneous 22), and mucosal 13), by hybrid capture‐based next‐generation sequencing. We show that tended harbor more pathogenic mutations than other types melanoma, though biological significance this finding remains uncertain....
Exploiting new non-metal-based peroxidase-mimic nanoenzymes for chemodynamic therapy (CDT) in cancer treatment is an active and challenging field. Here, we found that activated carbon nanoparticles (denoted as ANs) fabricated from coconut shell have satisfactory nanoenzyme activity. Based on this positive result, gadodiamide, a clinically used nuclear magnetic imaging contrast agent, was loaded inside the AN pores encapsulated by polyvinylpyrrolidone (PVP) to obtain Gd@PANs. PANs (ANs...
miR-206 plays an essential role in repressing the growth of multiple cancer cells. Glucose-6-phosphate dehydrogenase (G6PD) is rate-limiting enzyme pentose phosphate pathway. However, it mostly unknown whether G6PD associated with miR-206-mediated repression hepatocellular carcinoma (HCC) In this study, we found that expression was upregulated HCC patients and cell lines, whereas negatively clinical staging criterion primary liver cancer. Overexpression increased lipid accumulation promoted...
Cloud object storage such as AWS S3 is cost-effective and highly elastic but relatively slow, while high-performance cloud ElastiCache expensive provides limited elasticity. We present a new service called ServerlessMemory, which stores data using the memory of serverless functions. ServerlessMemory employs sliding-window-based management strategy inspired by garbage collection mechanisms used in programming language to effectively segregate hot/cold fine-grained elasticity, good...