A5079261021- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Supramolecular Self-Assembly in Materials
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- PARP inhibition in cancer therapy
- Computational Drug Discovery Methods
- Intraperitoneal and Appendiceal Malignancies
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Traumatic Brain Injury and Neurovascular Disturbances
First Hospital of Jilin University
2014-2025
Jilin University
2014-2025
Tsinghua University
2023-2025
Shanghai Jiao Tong University
2021-2023
Daping Hospital
2023
Jilin Province Tumor Hospital
2023
Army Medical University
2023
Dalian Medical University
2023
Harbin Medical University
2023
Peking University
2019-2022
Mechanically interlocked molecules are considered promising candidates for the construction of self-adaptive materials by virtue their fascinating structural and dynamic features. However, it is still a great challenge to fabricate such with higher complexity richer functionality. Herein, we propose concept mechanically aerogels (MIAs) in which three-dimensional (3D) porous frameworks made dense modules, thereby enabling integration mechanical adaptivity multifunctionality single entity. The...
Supramolecular polymer networks (SPNs) demonstrate great potential in the development of smart materials owing to their attractive dynamic properties. However, as they suffer from inherent weak bonding most noncovalent cross-links, it remains a significant challenge construct SPNs with outstanding mechanical performance. Herein, we exploit cryptand/paraquat host-guest recognition motifs cross-links prepare class highly strong and tough SPNs. Unlike those supramolecular relatively binding...
Colorectal cancer (CRC) is a common malignancy with notable recent shifts in its burden distribution. Current data on CRC can guide screening, early detection, and treatment strategies for efficient resource allocation. This study utilized from the latest Global Burden of Diseases, Injuries, Risk Factors (GBD) Study. Initially, series descriptive statistics were performed incident cases, deaths, disability-adjusted life years (DALYs), age-standardized rates (ASRs) CRC. Percentage changes...
Abstract Background The aim of this clinical trial is to evaluate the influence high and low ligation inferior mesenteric artery with apical lymph node dissection on anastomotic blood supply, retrieval rate, operative time leakage rate in rectal cancer surgery. Methods A total 57 C hinese patients were randomly distributed into group B underwent radical resection cancer. Patients artery, around root preservation left colic artery. marginal stump pressure was measured after colon...
BACKGROUND:Globally, gastric cancer (GC) is the third most common source of cancer-associated mortality. The aim this study was to identify key genes and circular RNAs (circRNAs) in GC diagnosis, prognosis, therapy further explore potential molecular mechanisms GC. MATERIAL AND METHODS:Differentially expressed (DEGs) circRNAs (DE circRNAs) between tissues adjacent non-tumor were identified from 3 mRNA circRNA expression profiles. Functional analyses performed, protein–protein interaction...
Robotic-assisted total mesorectal excision (RaTME) may be associated with reduced conversion to an open approach and a higher rate of complete (TME); however, studies on its advantages in intersphincteric resection (ISR) are inadequate.
Abstract Integrating non-invasive brain imaging techniques, particularly computed tomography (CT) and magnetic resonance (MRI), coupled with the advancement of artificial intelligence, is forging a key pathway for disease diagnosis, playing vital role in safeguarding human health 1–4 . A robust intelligence copilot essential clinical emergencies, functioning as central processing unit medical systems, aiming to revolutionize process, expedite diagnosis diseases, support treatment 5–7 In this...
Abstract Background Liver cancer is one of the most commonly diagnosed cancers and fourth leading cause cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib lenvatinib provide only modest survival benefit to patients with hepatocellular carcinoma (HCC). This study aims identify novel therapeutic strategies for HCC patients. Methods Integrated bioinformatics analyses a non-biased CRISPR loss function genetic screen were performed potential targets cells....
Understanding how colorectal cancer escapes from immunosurveillance and immune attack is important for developing novel immunotherapies cancer. In this study we evaluated the role of canonical Wnt signaling in regulation T cell function a mouse model. We found that cells expressed abundant ligands, intratumoral various Frizzled proteins. Meanwhile, both active β-catenin total were elevated cells. vitro indicated suppressed IFN-γ expression increased IL-17a activated CD4+ However, cytotoxic...
Background: Immune-related genes (IRGs) are critically involved in the tumor microenvironment (TME) of colon adenocarcinoma (COAD).Here, study was mainly designed to establish a prognostic model IRGs predict survival COAD patients.Methods: The Cancer Genome Atlas (TCGA), Immunology Database and Analysis Portal (ImmPort) database, Cistrome database were utilized for extracting data regarding expression immune gene-and tumor-related transcription factors (TFs), aimed at identification...
Abstract CO gas therapy has attracted enormous attention in tumor due to the abilities of mitochondrial damage and inhibition cellular respiration. However, inefficient random release greatly limit its application. Taking this into account, study constructs an acid‐unlocked nanostructure based on MPDA‐MnCO‐GOx@DSNPs, designated as MMGD. The enables microenvironment (TME) specific enzyme prodrug (manganese carbonyl, MnCO) cascade reaction, thus facilitating situ. Mesoporous polydopamine...
An increasing number of studies have shown that abnormal metabolism processes are closely correlated with the genesis and progression colorectal cancer (CRC). In this study, we systematically explored prognostic value metabolism-related genes (MRGs) for CRC patients. A total 289 differentially expressed MRGs were screened based on The Cancer Genome Atlas (TCGA) Molecular Signatures Database (MSigDB), 72 transcription factors (TFs) obtained from TCGA Cistrome Project database. clinical...
To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we generated mice deficient for colonic epithelial cells (CECs). Colons these displayed architectural changes mucosa signs inflammation, as well increased proliferation CECs associated with appearance low- high-grade dysplasias. The main initial events triggering those alterations A2–deficient appeared to be abnormal mitoses DNA damage. Cyclin deletion promoted development dysplasia adenocarcinomas a...
Almost all the current therapies against liver cancer are based on "one size fits all" principle and offer only limited survival benefit. Fortunately, synthetic lethality (SL) may provide an alternate route towards individualized therapy in cancer. The concept that simultaneous losses of two genes lethal to a cell while single loss is non-lethal can be utilized selectively eliminate tumors with genetic aberrations. Methods: To infer cancer-specific SL interactions, we propose computational...
Meckel's diverticulum is a remnant of the omphalomesenteric duct. It can lead to intestinal perforation, obstruction and gastrointestinal bleeding. While internal hernia caused by rarely reported.We report case 45-year old female patient who presented with on laparotomy was found have causing gangrene. Segmental bowel resection performed had uneventful recovery.In patients acute without previous abdominal surgery, its complications should be suspected.
PD0332991 (palbociclib/Ibrance®) is a cyclin-dependent kinase (CDK)4/6 inhibitor that has recently been approved for the treatment of estrogen receptor‑positive advanced breast cancer. The present study investigated antiproliferative effects on gastric cancer (GC) cells and underlying molecular mechanisms. activity was tested in several GC cell lines, including AGS, KATO‑Ⅲ, NCI‑N87 HS746T. Growth inhibitory PD0332991, alone or combination with fluorouracil (5‑FU), measured by MTT assay....