A5100357786- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Chemical Synthesis and Analysis
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- HVDC Systems and Fault Protection
- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Cardiovascular Issues in Pregnancy
- Ferroptosis and cancer prognosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Congenital Heart Disease Studies
- BRCA gene mutations in cancer
- Intraperitoneal and Appendiceal Malignancies
- Genetic Associations and Epidemiology
- Coronary Interventions and Diagnostics
- Sperm and Testicular Function
- Genomic variations and chromosomal abnormalities
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
First Affiliated Hospital of Wannan Medical College
2025
Nanjing University of Chinese Medicine
2022-2024
Affiliated Hospital of Guizhou Medical University
2024
Guizhou University
2024
Suzhou Traditional Chinese Medicine Hospital
2024
Ganzhou People's Hospital
2024
Gannan Medical University
2024
First Affiliated Hospital of Gannan Medical University
2024
Nanjing Medical University
2010-2023
Jiangsu Province Hospital
2006-2023
Objective. Inflammatory bowel disease (IBD), which mainly refers to Crohn's and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. Recent reports have demonstrated that exosomes derived from interleukin-10 (IL-10)-treated bone marrow-derived dendritic cells (DCs) can reduce incidence severity established collagen-induced arthritis (CIA) in mice. Based on essential role IL-10 development normal mucosal immunity, we investigated whether DCs treated with...
Abstract Autophagy is a cellular self-degradation process that plays crucial role in maintaining metabolic functions cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer. In cancer, dysregulated closely associated with the development of cancer drug resistance, it can have both oncogenic oncostatic effects. Research evidence supports connection between m6A modification human particularly Abnormalities are involved initiation progression by...
Abstract Objective Gastric cancer (GC) is one of the most prevalent malignant tumors in Asian countries. Studies have proposed that lncRNAs can be used as diagnostic and prognostic indicators GC due to high specificity expression involvement GC. Recently, N6-methyladenosine (m6A) has also emerged an important modulator This study aimed at establishing a novel m6A-related signature construct accurate models for predicting prognosis population. Methods First, levels m6A modification...
Indisulam exhibits antitumor activity against several cancer cells. Although the DCAF15-indisulam-RBM39 axis has been well documented in inhibition of cell growth, it is unknown whether RBM39 degradation alone mechanism action indisulam. Here, we verified inhibitory effect indisulam on proliferation gastric cells and its dependence DCAF15. Proximity-dependent biotin labeling with TurboID quantitative proteomics revealed that indeed promoted interaction between DCAF15 RBM39. Immunoblotting...
Sertoli cells are highly polarized testicular that provide a nurturing environment for germ cell development and maturation during spermatogenesis. The class III phosphatidylinositol 3-kinase (PtdIns3K) plays core roles in macroautophagy various types; however, its role remains unclear. Here, we generated mouse line which the gene encoding catalytic subunit, Pik3c3, was specifically deleted (cKO) found after one round of normal spermatogenesis, cKO mice quickly became infertile showed...
Background Comparisons between one‐ and two‐stent strategies for unprotected left main (UPLM) coronary bifurcation disease have yielded inconsistent results. This large‐sample, long‐term follow‐up study comparatively assessed stenting strategy impact in patients with distal disease. Methods Totally, 1,528 consecutive underwent percutaneous intervention a single center from January 2004 to December 2010 were enrolled; among them, 1033 UPLM lesions treated by one ( n = 661) or two 372)...
Comfrey is consumed by humans as a vegetable and tea, has been used an herbal medicine for more than 2000 years. Comfrey, however, hepatotoxic in livestock carcinogenic experimental animals. Our previous study suggested that comfrey induces liver tumors genotoxic mechanism the pyrrolizidine alkaloids plant are responsible mutation induction tumor initiation rat liver.In this study, we identified comfrey-induced gene expression profile livers of rats. Groups 6 male transgenic Big Blue rats...
Previous a genome-wide association study (GWAS) of colorectal cancer in Japanese population has identified risk region at the chromosome 6q26-q27 associated with risk. However, causal gene this locus remained unclear. In our study, we enrolled total 14 candidate functional single nucleotide polymorphisms (SNPs) (318 kb), and then genotyped them by TaqMan method Chinese including 1,147 cases 1,203 controls. Among that, 5 SNPs were statistical logistic regression analysis. Of which, SNP...
Protein ubiquitination is essential for multiple physiological processes through regulating the stability or function of target proteins and has been found to play critical roles in human cancers. However, protein profile metastatic colon adenocarcinoma tissue not elucidated yet. In this study, a proprietary ubiquitin branch (K-ε-GG) antibody-based label-free quantitative proteomics bioinformatics were performed identify global between primary (Colon) (Meta) tissues. A total 375 sites from...
Full-endoscopic discectomy is associated with a high risk of disc reherniation due to the poor mechanical strength annulus fibrosus after scar healing. It technically difficult place full-endoscopic suture. We designed an suture device that can be used defects under microendoscopy. The present study investigated safety and feasibility this technology. retrospectively analyzed outcomes patients who underwent surgical treatment for lumbar herniation (LDH) from January 2018 October 2020....
Our previous studies identified that the expression of microRNA‑29c (miR‑29c‑3p) was significantly increased in serum pregnant women carrying fetuses with congenital heart disease (CHD) compared normal women. However, mechanism by which miR‑29c‑3p affects development embryonic remained unclear. The aim present study to investigate effect and potential molecular overexpression on P19 cell proliferation, apoptosis differentiation. miR‑29c‑3p‑overexpression protein kinase Bγ (Akt3)‑knockdown...
The biological function of circular RNA 0000514 (circ_0000514) in breast cancer (bc) is still unknown. In this study, we downloaded the microarray dataset GSE101123 from Gene Expression Omnibus database and then analysed differentially expressed RNAs bc tissues compared with adjacent tissues, demonstrated that circ_0000514 was up-regulated tissues. Circ_0000514, miR-296-5p CXC chemokine ligand10 (CXCL10) expressions cell lines were probed by quantitativereal-time polymerase chain reaction...
The aim of this study was to compare the outcomes laparoscopic appendectomy (LA) using purse string invaginating sutures (PS) with those intracorporeal knotting (IK) or Hem-o-lock polymeric clips (HL). A total 882 patients who underwent from January 2015 December 2017 were studied retrospectively. Of these, 538 used PS, 229 IK and 115 HL close appendiceal stump. Their demographic characteristics, intraoperative findings postoperative complications analysed There similar percentages...
Abstract Objective E26 transformation‐specific (ETS) factors have emerged as key mediators underlying human tumorigenesis. Here, we sought to characterize the expression pattern, biological roles, and clinical significance of ETS Variant Transcription Factor 5 (ETV5) in head neck squamous cell carcinoma (HNSCC). Subjects Methods ETV5 pattern HNSCC was determined by bioinformatics interrogations immunohistochemical staining primary samples. The associations between its abundance with...
Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in Pfam database. It consists of 143 amino acids and has an isoelectric point 10.9. Crystals belonged to space group P1, with unit-cell parameters = 54.97, b 69.60, c 70.32 Å, α 103.71, β 111.06, γ 105.83°. The structure transcription regulator was solved at resolution 2.0 Å R(cryst) R(free) 21.2 24.9%, respectively. dimeric resembles that other proteins, each subunit comprising winged helix-turn-helix...
Abstract Congenital heart disease is one of the largest class birth defects. Eight subjects with ventricular septal defect (VSD, a kind congenital disease) and 11 health children were enrolled in tandem mass tags label‐based quantitative proteomic analysis to compare plasma proteins differentially abundance. A total 66 significantly upregulated or downregulated VSD patients compared healthy children. These involved pathways linked platelet activation, fructose mannose metabolism, complement...
To investigate the prognostic value of t(11; 18) (q21; q21) in gastric mucosa-associated lymphoid tissue lymphoma.A cohort thirty-six lymphoma patients who were pathologically identify diagnosis from January 1994 to June 2004 followed up retrospectively and studied using fluorescence situ hybridization(FISH) technique detect chromosomal translocation on preservative paraffin specimen.Among patients, fifteen (41.67%) positive for t (11; q21). All but one March 2010, general median survival...
Extracellular matrix (ECM) remodeling is one of the hallmark events in cancer and has been shown to be closely related tumor immunity. Immunotherapy evolved as an important tool treat various cancers improve patient prognosis. The positive response immunotherapy relies on unique interaction between microenvironment (TME). However, relationship ECM clinical outcomes, immune cell infiltration, colorectal (CRC) remains unknown. We systematically evaluated 69 remodeling-associated genes (EAGs)...