A5018801130- Metabolism, Diabetes, and Cancer
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Urological Disorders and Treatments
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Nanoplatforms for cancer theranostics
- Wnt/β-catenin signaling in development and cancer
- Prostate Cancer Treatment and Research
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Bladder and Urothelial Cancer Treatments
- TGF-β signaling in diseases
- Epigenetics and DNA Methylation
- Genital Health and Disease
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Sexual function and dysfunction studies
- Protein Degradation and Inhibitors
- Circular RNAs in diseases
First Affiliated Hospital of Gannan Medical University
2020-2025
Gannan Medical University
2022-2025
Gansu University of Traditional Chinese Medicine
2024
Ganzhou People's Hospital
2023-2024
Nanchang University
2015-2022
First Affiliated Hospital of Nanchang University
2015-2021
First Affiliated Hospital of Jiangxi Medical College
2015-2019
Boston University
2019
Abstract Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependent on its palmitoylation primarily mediated by the ZDHHC13 protein-acyl transferase, whether increasing represents a viable therapeutic target to limit melanomagenesis in redheads unknown. Here we identify specific and efficient vivo strategy induce benefit. We validate...
Abstract The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at forefront. RNA modification a subfield booming field epigenetics. To date, more than 170 types modifications have been described, and N6-methyladenosine (m6A) abundant well-characterized internal mRNAs involved in various aspects progression. METTL3, first identified key methyltransferase, regulates human mRNA non-coding expression an m6A-dependent manner. This review elucidates biological...
Adenosine monophosphate-activated protein kinase (AMPK) acts as a fuel gauge that maintains energy homeostasis in both normal and cancerous cells, has emerged tumor suppressor. The present study aims to delineate the functional relationship between AMPK transforming growth factor beta (TGF-β). Our results showed expression of liver B1 (LKB1), an upstream AMPK, impeded TGF-β-induced Smad phosphorylation their transcriptional activity breast cancer whereas knockdown LKB1 or AMPKα1 subunit by...
Abstract Autophagy is a cellular self-degradation process that plays crucial role in maintaining metabolic functions cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer. In cancer, dysregulated closely associated with the development of cancer drug resistance, it can have both oncogenic oncostatic effects. Research evidence supports connection between m6A modification human particularly Abnormalities are involved initiation progression by...
Disulfidptosis is a newly discovered form of cell death, and long non-coding RNAs (lncRNAs) play crucial role in tumor growth, migration, recurrence, drug resistance, particularly bladder cancer (BLCA). This study aims to investigate disulfidptosis-related lncRNAs (DRLs) as potential prognostic markers for BLCA patients. Utilizing single-cell sequencing data, RNA corresponding clinical information sourced from the GEO TCGA databases, this conducted annotation intercellular communication...
Abstract Background Solute carrier family 7 member 2 (SLC7A2), a cationic amino acid transporter, is lowly expressed in ovarian and hepatocellular cancers, which associated with their worse prognosis. However, its roles the prognosis, drug resistance immune infiltration non-small-cell lung cancer (NSCLC) are unclear. Methods We chose SLC7A2 from RNA-Seq of paclitaxel/cisplatin-resistant A549 cells, then bioinformatics, cell lines construction, RT-qPCR, CCK8 were performed to investigate...
Abstract Adenine monophosphate‐activated protein kinase ( AMPK ) is a fuel sensing enzyme that activated in shortage of energy and inhibited its surplus. Cancer metabolic disease characteristic aerobic glycolysis, namely Warburg effect, possesses heterogeneity featured by spatiotemporal hypoxia normoxia, where deeply implicated. The present study delineates the regulation mitochondrial functions cancer cells. On one hand, α subunit binds to mitochondria independently β targeting facilitates...
Obesity often concurs with nonalcoholic fatty liver disease (NAFLD), both of which are detrimental to human health. Thus far, exercise appears be an effective treatment approach. However, its effects cannot last long and, moreover, it is difficult achieve for many obese people. Thus, necessary look into alternative remedies. The present study explored a noninvasive, easy, tolerable physical alternative. In our experiment, C57BL/6 mice were fed high-fat diet (HFD) induce overweight/obesity...
The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis. SMAD3 phosphorylation is a crucial prognostic marker cancer.
// Deqiang Huang 1 , Xiaoling He 2, 3 Junrong Zou Pei Guo Shanshan Jiang Nonghua Lv Yuriy Alekseyev 4 Lingyu Luo Zhijun 3, 5 Research Institute of Digestive Diseases, The First Affiliated Hospital Nanchang University, Nanchang, Jiangxi, China 2 Graduate Program, Jiangxi Medical College, P.R. Basic Sciences, Departments Pathology and Laboratory Medicine, Boston University School Boston, MA 02118, USA Department Biochemistry, Correspondence to: Luo, e-mail: zluo@bu.edu 15270855639@163.com...