A5046473456- Non-Invasive Vital Sign Monitoring
- melanin and skin pigmentation
- Cancer, Hypoxia, and Metabolism
- ECG Monitoring and Analysis
- Glutathione Transferases and Polymorphisms
- Biochemical effects in animals
- Magnetism in coordination complexes
- Skin Protection and Aging
- Single-cell and spatial transcriptomics
- Aldose Reductase and Taurine
- Lanthanide and Transition Metal Complexes
- Gout, Hyperuricemia, Uric Acid
- Pesticide and Herbicide Environmental Studies
- Pesticide Exposure and Toxicity
- Melanoma and MAPK Pathways
- Mitochondrial Function and Pathology
- Heart Rate Variability and Autonomic Control
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Chromosomal and Genetic Variations
- Histone Deacetylase Inhibitors Research
- Weed Control and Herbicide Applications
- Advanced biosensing and bioanalysis techniques
- Plant Disease Resistance and Genetics
Guangdong Provincial People's Hospital
2019-2025
Jinan University
2025
Nanjing Tech University
2023-2024
Nanyang Normal University
2014-2024
University of Wisconsin–Madison
2019-2024
Cranfield University
2023-2024
Xi’an Jiaotong-Liverpool University
2024
Southern Medical University
2019-2024
Anyang Normal University
2024
Zhongshan Hospital
2024
Abstract Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate PRC2, H3K27M, is associated with certain pediatric brain cancers and linked to a global decrease H3K27me3 affected cells thought be mediated by inhibition PRC2 activity. We present here crystal structure human inhibitory H3K27M peptide bound active site domain, methionine residue located pocket that...
Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing part by installing methylation marks on lysine 27 of histone 3. Dysregulation PRC2 function correlates with certain malignancies and poor prognosis. EZH2 is the catalytic engine thus represents key candidate oncology target for pharmacological intervention. Here we report optimization our indole-based inhibitor series that led identification CPI-1205, highly potent (biochemical IC50 = 0.002...
Abstract The major genetic determinants of cutaneous melanoma risk in the general population are disruptive variants ( R alleles) melanocortin 1 receptor MC1R ) gene. These alleles also linked to red hair, freckling, and sun sensitivity, all which known phenotypic factors. Here we report that melanomas for somatic C>T mutations, a signature exposure, expected single-nucleotide variant count associated with presence an allele is estimated be 42% (95% CI, 15–76%) higher than among persons...
Several have shown plasma to be efficacious against cancer cells in vitro and vivo with minimal damage non‐cancerous tissue. Most are focused on direct influence of tumor cells. However, the body's immune system also plays a crucial role control cancer. A new concept immunogenic cell death (ICD) has been emerging, where through this modality death, an response may stimulated. The goal presented study was explore regime treatment that induces ICD stimulates anti‐tumor effects macrophages‐ key...
Hypoxia-inducible factor 1 (HIF-1) transcriptionally promotes production of adenosine triphosphate (ATP) whereas AMPK senses and regulates cellular energy homeostasis. A histone deacetylase (HDAC) activity has been proven to be critical for HIF-1 activation but the underlying mechanism its role in homesostasis remain unclear. Here, we demonstrate that depends on a cytosolic, enzymatically active HDAC5. HDAC5 knockdown impairs hypoxia-induced HIF-1α accumulation transactivation,...
Abstract Spatial transcriptomics is a powerful and widely used approach for profiling the gene expression landscape across tissue with emerging applications in molecular medicine tumor diagnostics. Recent spatial experiments utilize slides containing thousands of spots spot-specific barcodes that bind RNA. Ideally, unique identifiers (UMIs) at spot measure expression, but this often not case practice due to bleed from nearby spots, an artifact we refer as swapping. To improve power precision...
The DOT1L histone H3 lysine 79 (H3K79) methyltransferase plays an oncogenic role in MLL-rearranged leukemogenesis. Here, we demonstrate that, contrast to leukemia, a protective ultraviolet radiation (UVR)-induced melanoma development. Specifically, the gene is located frequently deleted region and undergoes somatic mutation human melanoma. Specific mutations functionally compromise enzyme activity leading reduced H3K79 methylation. Importantly, absence of DOT1L, UVR-induced DNA damage...
Abstract Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependent on its palmitoylation primarily mediated by the ZDHHC13 protein-acyl transferase, whether increasing represents a viable therapeutic target to limit melanomagenesis in redheads unknown. Here we identify specific and efficient vivo strategy induce benefit. We validate...
Glutaminolysis and Warburg effect are the two most noticeable metabolic features of tumor cells whereas their biological significance in cell proliferation remains elusive. A widely accepted current hypothesis is that use glutamine as a preferred carbon source for energy reducing power, which has been used to explain both glutaminolysis effect. Here we provide evidence show supplying nitrogen, not skeleton, underlies major importance proliferating cells. We alternative nitrogen mechanisms...
Twin-core fiber (TCF)-based sensor was proposed for non-invasive vital sign monitoring, including respiration and heartbeat.The TCF homemade the corresponding fabricated by sandwiching single-mode (SMF) on both ends.The offset distance between SMF optimized while length of identified from preliminary measurement results.Then, TCF-based attached under a mattress to realize monitoring.Both heartbeat signal can be obtained simultaneously, which is consistent with reference signals.For further...
Abstract Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC) variants are associated with impaired DNA damage repair and increased melanoma risk. MC1R signaling is critically dependent on palmitoylation, primarily mediated by protein acyltransferase zinc finger DHHC-type palmitoyltransferase 13 (ZDHHC13). A better understanding of how ZDHHC13 physiologically activated could help identify approaches to prevent melanomagenesis redheads....
Polyvinylidene fluoride (PVDF) based polymer nanocomposites with ceramics as nanofiller have been investigated a solution for energy storage devices due to their unique and attractive combination of processability electrical properties. This work assesses two dopants (fluorine nitrogen) zinc oxide (ZnO) nanoparticles PVDF matrix composites means improving dielectric properties targeting capacitive storage. Fluorine doping achieves improved performance compared pure ZnO increasing the...
We report the synthesis and characterization of a symmetric dinucler DyIII complex (1) based on use bulk pentapyridyldiamine (BPA-TPA) bridging hydroquinone ligands. Each ion is wrapped by BPA-TPA ligand, leaving only one site to bond O donor atom from hydroquinone, which generates triangular dodecahedral coordinate geometry. Magnetic measurements reveal that 1 exhibits high anistropy barrier 727(4) K temperature hysteresis loops up 20 with remanence at zero field. However, Y(III)-diluted...