A5049564058- Plasma Applications and Diagnostics
- Electrohydrodynamics and Fluid Dynamics
- Plasma Diagnostics and Applications
- Microbial Inactivation Methods
- Laser-induced spectroscopy and plasma
- Burn Injury Management and Outcomes
- Aerosol Filtration and Electrostatic Precipitation
- Plasma and Flow Control in Aerodynamics
- Mass Spectrometry Techniques and Applications
- Laser Design and Applications
- Dermatologic Treatments and Research
- Surface Modification and Superhydrophobicity
- Diamond and Carbon-based Materials Research
- Bacillus and Francisella bacterial research
- Electrostatic Discharge in Electronics
- nanoparticles nucleation surface interactions
- Laser-Matter Interactions and Applications
- Methane Hydrates and Related Phenomena
- Laser Applications in Dentistry and Medicine
- Nonmelanoma Skin Cancer Studies
- Nanomaterials and Printing Technologies
- bioluminescence and chemiluminescence research
- Nitric Oxide and Endothelin Effects
- Periodontal Regeneration and Treatments
- Listeria monocytogenes in Food Safety
Drexel University
2013-2024
Coriell Institute For Medical Research
2012-2017
Equilibrium Research
2013
Mechanisms of plasma interaction with living tissues and cells can be quite complex, owing to the complexity both tissue. Thus, unification all mechanisms under one umbrella might not possible. However, authors are attempting make first steps in this direction. In paper, analysis floating electrode dielectric barrier discharge (FE-DBD) is presented biological physical discussed. mechanisms, charged species identified as major contributors desired effect a mechanism proposed. Biological also...
Here we present the results of an experimental study effect ions produced in a dc corona discharge on inactivation bacteria surface agarose gel. Both positive and negative discharges various gases at different humidities were studied. The measurements air, O(2), N(2), Ar He mixtures show that there is no pure O(2) N(2)-H(2)O mixture. best achieved case direct treatment, when was ignited oxygen water-containing mixtures. We neither UV radiation, ozone or H(2)O(2) nor other neutral active...
Several have shown plasma to be efficacious against cancer cells in vitro and vivo with minimal damage non‐cancerous tissue. Most are focused on direct influence of tumor cells. However, the body's immune system also plays a crucial role control cancer. A new concept immunogenic cell death (ICD) has been emerging, where through this modality death, an response may stimulated. The goal presented study was explore regime treatment that induces ICD stimulates anti‐tumor effects macrophages‐ key...
In this paper we report the results on study of non-equilibrium nanosecond discharge generation in liquid media. Here studied both water and silicon transformer oil, present our findings behaviour depending global (applied) electric, emission spectrum shadow imaging discharge. We also discuss possible scenarios development suggest that operates a leader-type regime supported by electrostriction effect—creation nano-sized pores due to high local electric field.
Abstract Plasma has been shown to be effective against cancer cells both in vitro and vivo. Several studies have documented the selectivity of plasma with minimal or reduced damage normal cells. However, complete remission following treatment not achieved yet. In body, immune system plays a vital role prevention control cancer. Presence adaptive tumor microenvironment is usually an indicator good prognosis. Since cell migration key initial step towards defense diseases, it important evaluate...
Abstract In this manuscript, we report on observations of the development nanosecond-pulsed plasma in liquids and examine with two drastically different properties: water liquid nitrogen. Here, compare discharge appearance using high-speed imaging, bubble formation shadow measure time-averaged optical emission spectra these plasmas. Because nitrogen is ignited a that at boiling temperature, also study various temperatures, up to boiling. We demonstrate appears not be affected by type liquid....
In this study, we report experimental results on fast intensified charge-coupled device (ICCD) imaging of the development nanosecond-pulsed dielectric barrier discharge (DBD) in atmospheric air and spectroscopic measurements electric field discharge. The uniformity images obtained with nanosecond exposure times was analysed using chi-square test. indicate that DBD strongly depends applied (global) gap, which is a threshold phenomenon. We show case strong overvoltage gap (provided by rise...
Bacillus spores represent one of the most resistant organisms to conventional sterilization methods. This paper is focused on inactivation two species, cereus and anthracis, using atmospheric-pressure dielectric-barrier-discharge (DBD) plasma. Spores treated in liquid or air-dried a solid surface were effectively inactivated within 1 min DBD plasma treatment at discharge power 0.3 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ....
This paper has been rejected on March 28, 2012, because of a possible breach ethics. The author informed.
Nitric oxide has great potential for improving wound healing through both inflammatory and vascularization processes. can be produced in high concentrations by atmospheric pressure thermal plasmas. We measured the physical characteristics nitric production of a pin-to-hole spark discharge (PHD) plasma, as well plasma-produced delivery into liquid endothelial cells. The plasma temperature was calculated 9030 ± 320 K Boltzmann method, which adequate to produce oxide, although average gas near...
Atmospheric pressure non‐equilibrium plasmas are efficacious in killing both prokaryotic and eukaryotic cells. While the mechanism of plasma induced cell death has been thoroughly studied prokaryotes, detailed investigation mediated is still pending. When generated, four major components that interact with cells produced: electric fields, radiation, charged particles, neutral gas species. The goal this study was to determine which responsible for plasma‐induced by isolating removing each...
In this study we have studied the initial stage of nanosecond-pulsed discharge development in liquid phase. Modelling predicts that case fast rising strong nonhomogeneous electric fields vicinity high-voltage pin electrode a region saturated with nanoscale non-uniformities may be developed. This phenomenon is attributed to electrostriction mechanisms and used explain breakdown work, schlieren method was order demonstrate formation negative pressure liquids different dielectric permittivity...
For the energy industry, a process that is able to transform methane—being prime component of natural gas—efficiently into liquid product would be equivalent goose with golden eggs. As such it no surprise research efforts in this field already date back nineteen hundreds. Plasma technology can considered novel player field, but nevertheless one great potential. Over past decades has evolved from sole hydrogen production, over indirect methane liquefaction eventually direct plasma‐assisted...
The article presents the results of studies on modification cement stone with microadditives inorganic salts, such as CaCl2, Ca(NO3)2, CaSO4 and CuSO4. Salts were introduced into composition in form a 2 % solution amount 0,2 to 1 %, while consumption dry salt ranged from 0,004 0,02 by weight cement. All additives microdosages based mass are accelerators hardening modifiers that increase its strength. It has been proven strength salts occurs early stages hardening. maximum values shown...
Cold atmospheric pressure plasmas have emerged as a promising new tool for medical applications. Compared to conventional thermal plasma, such arc coagulators and desiccators, cold plasma can be more selective in its application may used effective sterilization of skin wound tissue, healing tissue regeneration, cancer treatment blood coagulation. One the key questions that has answered before these technologies are introduced practice is safety living tissues, i.e. toxic dose levels exposure...
In this article we present an in vitro model based on agarose gel that can be used to simulate a dirty, oily, bloody, and morphologically complex surface of, for example, open wound. We show model's effectiveness simulating the depth of penetration reactive species generated plasma (e.g., hydrogen peroxide) deep into tissue rat confirm depths using model. envision such could future study discharges (and other modalities) minimize use live animals; optimized wound then finally verified actual
This work investigates the development of nanosecond pulsed discharges in water ignited with application both positive and negative polarity pulses to submerged pin plane electrodes. Optical diagnostics are used study two main aspects these discharges: initiation phase, phase. Nanosecond up 24 kV 4 ns rise time, 10 duration 5 fall time ignite a 1.5 mm gap between copper plate tungsten needle radius curvature 25 um. Fast ICCD imaging is trace discharge over varying applied pulse amplitudes...
The microsecond spark discharge plasma jet is experimentally analyzed, and numerical modeling performed. It shown that appears as a the number of microdischarges resulting in average gas temperature about 40 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> C-50 C. Fast imaging are performed order to study development on both nanosecond time scales. biochemical production delivery reactive oxygen nitrogen species ( H <sub...
The goal of this study was to investigate whether cold plasma generated by dielectric barrier discharge (DBD) modifies extracellular matrices (ECM) influence chondrogenesis and endochondral ossification. Replacement cartilage bone during ossification is essential in fetal skeletal development, growth fracture healing. Regulation process the ECM occurs through matrix remodelling, involving a variety cell attachment molecules factors, which morphology protein expression. commercially available...
Using a multi-gas plasma jet, we generated plasmas of various gas species such as argon, oxygen, nitrogen, carbon dioxide, and air. Photometric measurements colorforming reactions were used to identify singlet OH radicals, hydrogen peroxide, NO nitrite, nitrate, which are important sterilization agents that in the liquid phase. Oxygen largest amount peroxide. Air nitrate. The pH air plasma−treated water for 120 s dropped below 3.0. sterilized Escherichia coli distilled after treatment. In...
In this paper, based on a theoretical model [1], it has been shown experimentally that the initial stage of development nanosecond breakdown in liquids is associated with appearance discontinuities liquid (cavitation) under influence electrostriction forces. Comparison measured area dimensions and its temporal were found to be good agreement calculations.
Cold plasma discharges have been shown to medically-relevant therapeutic effects when applied living tissues, including blood coagulation and wound healing; thus, treatment of inflamed tissues in ulcerative colitis disease may be an effective approach reduce adverse consequences if not cure the disease. Here we discuss results first experimental study cold a mouse model. As source, spark discharge has used. The show that model mice some beneficial by suppressing progression while no damage...