A5100322947- Metabolism, Diabetes, and Cancer
- Traditional Chinese Medicine Analysis
- Medical Research and Treatments
- Pancreatic function and diabetes
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Cancer-related Molecular Pathways
- Healthcare and Venom Research
- PI3K/AKT/mTOR signaling in cancer
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- Cancer Risks and Factors
- Peroxisome Proliferator-Activated Receptors
- Biological and pharmacological studies of plants
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Neuroblastoma Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Spectroscopy and Chemometric Analyses
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Medicinal plant effects and applications
- Mental Health Treatment and Access
Hebei Medical University
2012-2025
Third Hospital of Hebei Medical University
2012-2025
Xi'an Jiaotong University
2020-2025
AstraZeneca (United Kingdom)
2024
National Institute of Biological Sciences, Beijing
2024
Jinzhong University
2024
Ningxia Medical University
2022-2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
Beijing Hospital of Traditional Chinese Medicine
2023
Diabetic wounds represent a severe clinical challenge in which impaired M2 macrophage polarization and continuous glycolysis play crucial roles. Calycosin-7-glucoside (CG) is an isoflavone component Astragali Radix (AR), has become research focus for treating diabetic following reports indicating that it anti-inflammatory effects. However, the mechanism through CG can treat yet to be deciphered.This study aimed evaluate therapeutic effect of on its underlying mechanism.The potential...
BACKGROUND Metformin has been reported to inhibit the growth of different types cancers, including prostate cancer. We were interested understand if effect metformin on cancer is AR‐dependent and, so, whether could act synergistically with other anti‐AR agents serve as a therapeutic regimen high efficacy and low toxicity. METHODS Cell viabilities apoptosis determined by MTT assay annexin V‐FITC staining, respectively, when two human cell lines, androgen‐dependent LNCaP androgen‐independent...
This study was aimed to explore the mechanism of Sishen Wan (SSW) in treating ulcerative colitis (UC) a rat model spleen-kidney yang deficiency pattern by regulating gut microbiota and content butyric acid short-chain fatty (SCFAs) restoring regulatory T (Treg)/T helper type 17 (Th17) balance from perspective correlation between immune function.The UC established method combining disease syndrome (intragastric administration senna leaf, subcutaneous injection hydrocortisone, enema with...
Objective This study aimed to investigate the association between four insulin resistance (IR) surrogates and bone mineral density (BMD) whether IR could be risk factors for osteoporosis (OP) in Chinese non-diabetic postmenopausal individuals.
Abstract Adenine monophosphate‐activated protein kinase ( AMPK ) is a fuel sensing enzyme that activated in shortage of energy and inhibited its surplus. Cancer metabolic disease characteristic aerobic glycolysis, namely Warburg effect, possesses heterogeneity featured by spatiotemporal hypoxia normoxia, where deeply implicated. The present study delineates the regulation mitochondrial functions cancer cells. On one hand, α subunit binds to mitochondria independently β targeting facilitates...
Chloroquine can induce an increase in the cellular uptake of glucose; however, underlying mechanism is unclear.In this study, translocation GLUT4 and intracellular Ca2+ changes were simultaneously observed by confocal microscope L6 cells stably over-expressing IRAP-mOrange. The fusion with plasma membrane (PM) was traced using HA-GLUT4-GFP. Glucose measured a cell-based glucose assay. protein detected Western blotting mRNA level RT-PCR.We found that chloroquine induced significant increases...
Insulin stimulates glucose uptake by inducing translocation of transporter 4 (GLUT4) from intracellular resides to the plasma membrane. How GLUT4 storage vesicles are translocated cellular interior membrane remains be elucidated. In present study, transport and kinetics their docking at were comprehensively investigated single vesicle level in control microtubule‐disrupted 3T3‐L1 adipocytes time‐lapse total internal reflection fluorescence microscopy. It is demonstrated that microtubule...
Type 2 diabetes mellitus (T2DM) is a kind of disorder glucose and lipid metabolism with the main clinical manifestation long-term higher blood level than normal value. Farnesol X receptor (FXR)/ceramide signaling pathway plays an important role in regulating cholesterol metabolism, homeostasis, absorption fat vitamins diet. Gegen Qinlian Decoction (GQD) classical herbal formula, which has good therapeutic effect on diabetes-related metabolic syndrome.To investigate hepatic gluconeogenesis...
Background and purpose: Previous studies have found that metformin can inhibit tumor growth improve outcomes for cancer patients. However, the association between addition of to treatment regimen survival in non-small cell lung (NSCLC) patients receiving antineoplastic agents such as chemotherapy drugs, epidermal factor receptor tyrosine kinase inhibitors (EGFR-TKIs), immune checkpoint (ICIs) remains unclear. This study aimed evaluate effect NSCLC who received aforementioned therapies....
PEG–poly(amino acid)s are used as a novel drug carrier for the treatment of hepatoma.
Abstract Chronic inflammation plays a positive role in the development and progression of colitis‐associated colorectal cancer (CAC). Medicinal plants their extracts with anti‐inflammatory immunoregulatory properties may be an effective treatment prevention strategy for CAC. This research aimed to explore potential chemoprevention paeoniflorin (PF) CAC by network pharmacology, molecular docking technology, vivo experiments. The results showed that interleukin‐6 (IL‐6) is key target PF...
Abstract Background Insulin-stimulated glucose uptake into skeletal muscle occurs via translocation of GLUT4 from intracellular storage vesicles to the plasma membrane. Elevated free fatty acid (FFA) availability a lipid infusion reduces disposal, but this in absence impaired proximal insulin signalling. Whether localisation membrane is subsequently affected by elevated FFA not known. Methods Trained ( n = 11) and sedentary 10) individuals, matched for age, sex body mass index, received...
The purpose of this study is to investigate college students and examine the current status their mental health, so as provide a basis for improving health students. Three hundred ninety-six were selected research subjects was investigated by questionnaire method. results showed that: 1. mean scores each dimension SCL-90 total ranged from 1.2654 1.7997, which higher than theoretical value asymptomatic (1 point); also (90 points). 2. number whose 10 dimensions SCL-90, score scale reached...
<sec> <title>BACKGROUND</title> Virtual community, as a platform providing social connections, has received research attention in the medical field. However, there is currently no virtual community tailored for outpatient cancer patients. This study presents preliminary data on customized designed to offer companionship and sharing </sec> <title>OBJECTIVE</title> aims assess feasibility initial effectiveness of newly developed application improving quality life (QOL) among...