A5101626368- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Biochemical Analysis and Sensing Techniques
- Facial Rejuvenation and Surgery Techniques
- Gene expression and cancer classification
- Sepsis Diagnosis and Treatment
- Ion channel regulation and function
- RNA modifications and cancer
- Renal function and acid-base balance
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Cancer Research and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Biotin and Related Studies
- Phagocytosis and Immune Regulation
- Advanced MRI Techniques and Applications
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- Ocular Disorders and Treatments
- Supramolecular Self-Assembly in Materials
Northern Jiangsu People's Hospital
2025
Hangzhou Hospital of Traditional Chinese Medicine
2025
Hangzhou City University
2025
Jiangxi Maternal and Child Health Hospital
2023
Institute of Biophysics
2015-2020
Chinese Academy of Sciences
2016-2020
Fujian Agriculture and Forestry University
2018
Huazhong University of Science and Technology
2015
Tongji Hospital
2015
Peking University Cancer Hospital
2009
Objective To investigate the application value of ultrasound artificial intelligence S-Detect technology in differential diagnosis benign and malignant breast nodules. Methods Suspicious nodules were examined using technology, conventional (US), contrast-enhanced (CEUS). The diagnoses compared with final pathological results to analyze diagnostic efficacy these three techniques distinguishing from Results accuracy diagnosing was 0.859, a sensitivity 0.915, specificity 0.839, an area under...
Chloroquine can induce an increase in the cellular uptake of glucose; however, underlying mechanism is unclear.In this study, translocation GLUT4 and intracellular Ca2+ changes were simultaneously observed by confocal microscope L6 cells stably over-expressing IRAP-mOrange. The fusion with plasma membrane (PM) was traced using HA-GLUT4-GFP. Glucose measured a cell-based glucose assay. protein detected Western blotting mRNA level RT-PCR.We found that chloroquine induced significant increases...
Abstract Uncovering the functionally essential variations related to tumorigenesis and tumor progression from cancer genomics data is still challenging due genetic diversity among patients, extensive inter- intra-tumoral heterogeneity at different levels of gene expression regulation, including but not limited genomic, epigenomic, transcriptional levels. To minimize impact germline heterogeneities, in this study, we establish multiple primary cultures recurrent tumors a single patient with...
To provide superior cosmetic results and reduce complications, unlike traditional evisceration coupled with implant insertion technique its modifications, we have developed a novel simple for anophthalmic patients.All patients who underwent the scleral-muscle flaps procedure in placement of hydroxyapatite were included study. Main outcome measures complications such as exposure, infection, chemosis, conjunctival inclusion cysts, granulomas. Meanwhile, motility was indirectly measured...
In order to provide a new method for the identification of Placenta hominis, COI barcode has been employed identify P. hominis medicinal materials and its adulterants. Genomic DNA was extracted from experimental samples. The sequences were amplified sequenced bi-directionally. Sequence assembly consensus sequence generation performed using CodonCode Aligner. NJ tree constructed by MEGA6.0 software. can be successfully obtained all intra-specific variation inter-specific divergence...
Background: Phenylalanine hydroxylase deficiency (PAHD) is an autosomal recessive disorder of amino acid metabolism and caused by mutations in the phenylalanine (PAH) gene. Without timely appropriate dietary management, disturbance may impair cognitive development neurophysiological function. Newborn screening (NBS) can aid early diagnosis PAHD, which give accurate therapy to PAHD patients time. In China, incidence PAH mutation spectrum vary enormously across provinces. A total 5,541,627...
Objective To observe the influence on sensitivity of pancreatic cancer cell line BxPC-3 to gemcitabine silencing PAUF gene. Methods BxPC-3 cells, which overexpress PAUF, was stably transfected with PAUF-shCtrl and PAUF-shRNA establish BxPC-3_shCtrl BxPC-3_shPAUF cells as control experiment group. Then mRNA protein expression level in these two lines were detected by RT-PCR western blot, respectively. The growth inhibition rates treated different concentrations (0, 3.1, 6.25, 12.5, 25,...
Abstract To uncover the functionally essential variations related to tumorigenesis and tumor progression from large amount of cancer genomics data is still challenging due genetic diversity between patients, extensive inter- intra-tumor heterogeneity at genomic, epigenomic, transcription levels. Multiple primary cultures derived phenotypically distinct subpopulations a single patient may not only represent cell types states (such as metastasis drug-resistant), but also narrow analysis in...