A5101615937- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Conducting polymers and applications
- Circular RNAs in diseases
- Electromagnetic wave absorption materials
- Metamaterials and Metasurfaces Applications
- Organic Electronics and Photovoltaics
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Evolution and Genetic Dynamics
- Advanced Antenna and Metasurface Technologies
- Microbial Metabolic Engineering and Bioproduction
- Lung Cancer Treatments and Mutations
- Fungal and yeast genetics research
- Glioma Diagnosis and Treatment
- Fullerene Chemistry and Applications
- Advanced Mathematical Modeling in Engineering
- Heusler alloys: electronic and magnetic properties
- Plant tissue culture and regeneration
- Lipid metabolism and biosynthesis
- Cancer therapeutics and mechanisms
- Polymer composites and self-healing
- Cooperative Studies and Economics
Shandong First Medical University
2022-2025
Shandong Tumor Hospital
2022-2025
China National Rice Research Institute
2022-2025
Academy of Medical Sciences
2024
Shandong Normal University
2024
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2017-2023
Nankai University
2017-2023
Annoroad Gene Technology (China)
2023
Chinese Academy of Sciences
2019-2022
Beijing Institute of Genomics
2017-2022
Abstract As a next generation of detection technology, terahertz technology is very promising. In this work, highly efficient wave absorber based on 3D graphene foam (3DG) first reported. Excellent absorption property at frequency ranging from 0.1 to 1.2 THz obtained owing faint surface reflection and enormous internal absorption. By precise control the constant properties for 3DG, loss (RL) value 19 dB acquired qualified bandwidth (with RL over 10 dB) covers 95% entire measured normal...
A novel small molecule acceptor MeIC with a methylated end-capping group is developed. Compared to unmethylated counterparts (ITCPTC), exhibits higher lowest unoccupied molecular orbital (LUMO) level value, tighter packing, better crystallites quality, and stronger absorption in the range of 520-740 nm. The MeIC-based polymer solar cells (PSCs) J71 as donor, achieve high power conversion efficiency (PCE), up 12.54% short-circuit current (JSC ) 18.41 mA cm-2 , significantly than that device...
A high-quality Fe3GeTe2 single crystal with good electrical, magnetic, and electromagnetic wave absorption shielding properties was prepared in a large quantity (10 g level) by solid-phase sintering recrystallization method, which would promote its in-depth research practical application. It has room-temperature electrical mobility of 42 cm2/V·s, sheet (bulk) carrier concentration +1.64 × 1018 /cm2 (+3.28 1020 /cm3), conductivity 2196.35 S/cm. Also, Curie temperature 238 K indicates the high...
Abstract Fe 3 GeTe 2 provides an ideal system for the study of itinerant ferromagnetism. However, Curie temperature (Tc) below room limits its further in‐depth research and wide applications. Here, Tc 224 K is greatly increased to 496 /FeTe /Fe Ge by temperature‐induced self‐decomposition doping, contributing improve electromagnetic response enhancing absorption strength bandwidth boosting application potentials at higher temperatures. Then, achieve multispectral compatible strong...
How many incoming travelers (I0 at time 0, equivalent to the 'founders' in evolutionary genetics) infected with SARS-CoV-2 who visit or return a region could have started epidemic of that region? I0 would be informative about initiation and progression epidemics. To obtain , we analyze genetic divergence among viral populations different regions. By applying 'individual-output' model drift diversities, < 10, which been achieved by one traveler long-distance flight. The conclusion is robust...
The pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), etiological agent of disease 2019 (COVID-19), has caused immense global disruption. With rapid accumulation SARS-CoV-2 genome sequences, however, thousands genomic variants are now publicly available. To improve tracing viral genomes' evolution during development pandemic, we analyzed single nucleotide (SNVs) in 121,618 high-quality genomes. We divided these genomes into two major lineages (L and S) based...
Abstract Background In recent years,the lack of specific markers for the diagnosis colorectal cancer has led to an upward trend in both morbidity and mortality from this condition. There is urgent need identify molecular biomarkers that contribute early detection. This study aimed exosomal microRNAs hold potential as diagnostic CRC. Methods We screened differentially expressed miRNAs using CRC exosome dataset GSE39833. To validate results public database, we collected serum 168 patients...
Abstract Establishing the protein–protein interaction network sheds light on functional genomics studies by providing insights from known counterparts. However, rice interactome has barely been studied due to lack of massive, reliable, and cost‐effective methodologies. Here, development a barcode‐indexed PCR coupled with HiFi long‐read sequencing pipeline (BIP‐seq) is reported for high throughput Protein Interaction (PPI)identification. BIP‐seq essentially built integration library versus...
The probabilistic diffusion model (DM), generating content by inferencing through a recursive chain structure, has emerged as powerful framework for visual generation. After pre-training on enormous unlabeled data, the needs to be properly aligned meet requirements downstream applications. How efficiently align foundation DM is crucial task. Contemporary methods are either based Reinforcement Learning (RL) or truncated Backpropagation (BP). However, RL and BP suffer from low sample...
Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack of comprehensive multi-omics analysis TOP2A from pan-cancer perspective, despite its significance. A multiomics was conducted to investigate across various cancer types. This study involved the integration over 10,000 multidimensional genomic datasets 33 distinct types, obtained The Cancer Genome Atlas (TCGA). focused on evaluating overall activity...
Two new non-fullerene acceptors, IDTC and IDTO, were designed synthesized for the application in organic solar cells (OSCs). Compared with IDTC, introduction of electron-donating alkoxy groups IDTO leads to a higher LUMO level slightly blue-shifted absorption. Using polymer PBDB-T as donor two small molecules acceptors conventional device structure, IDTC-based OSC exhibits power conversion efficiency (PCE) 9.35% an open-circuit voltage (VOC) 0.917 V, short-circuit current density (JSC) 16.56...
Abstract Background Tumor-derived exosomal miRNAs play crucial roles in cancer diagnosis. Current studies aim to identify associated with colorectal (CRC) that are noninvasive, sensitive, and specific. Patients methods Exosomes were extracted from CRC patients healthy donors via ultracentrifugation, followed by verification transmission electron microscopy (TEM), qNano, Western blot analysis. The differential expression levels clinical characteristics of miR-205-5p analyzed data Cancer...
Abstract Colorectal cancer is a common malignant tumor, whose growth and metastasis are influenced by numerous factors. MicroRNAs have garnered increasing attention in recent years due to their involvement tumor development. Exosomes involved intercellular signaling influence development promoting cell proliferation through activation of angiogenesis other mechanisms. This study aimed investigate how the exosomes containing miR-320d from colorectal (CRC) cells promote regulating...
Abstract Uncovering the functionally essential variations related to tumorigenesis and tumor progression from cancer genomics data is still challenging due genetic diversity among patients, extensive inter- intra-tumoral heterogeneity at different levels of gene expression regulation, including but not limited genomic, epigenomic, transcriptional levels. To minimize impact germline heterogeneities, in this study, we establish multiple primary cultures recurrent tumors a single patient with...
Fullerene and non-fullerene hybrids were designed synthesized for polymer solar cells as small molecule acceptors.
Spatial genetic and phenotypic diversity within solid tumors has been well documented. Nevertheless, how this heterogeneity affects temporal dynamics of tumorigenesis not rigorously examined because do evolve as the standard population model due to spatial constraint. We therefore, propose a neutral (NS) whereby mutation accumulation increases toward periphery; genealogical relationship is spatially determined selection efficacy blunted (due kin competition). In model, mutations are accrued...
Topoisomerases are nuclear enzymes that get to the bottom of topological troubles related with DNA all through a range genetic procedures. More and more studies have shown topoisomerase-mediated cleavage plays crucial roles in tumor cell death carcinogenesis. There is however still lack comprehensive multi-omics topoisomerase family genes from pan-cancer perspective. In this study, multiomics analysis was conducted by integrating over 10,000 multi-dimensional cancer genomic data across 33...
Abstract Astrocytoma and glioblastoma (GB) are reclassified subtypes of adult diffuse gliomas based on distinct isocitrate dehydrogenase ( IDH ) mutation in the fifth edition WHO Classification Tumors Central Nervous System. The recurrence is a common inevitable challenge, analyzing genomic alterations astrocytoma GB could provide insights into their progression. This study conducted longitudinal investigation, utilizing whole-exome sequencing, 65 paired primary/recurrent gliomas. It...
Abstract Background: Tumor-exosomal miRNA play crucial roles in cancer diagnosis. The current reports aimed to found an exosomal for colorectal cancer(CRC) with non-invasiveness, sensitivity and specificity. Patients methods: exosome was extracted from CRC patients healthy donors using ultracentrifugation verify by TEM, qNano western blot. Differential expression level clinical characterization of miR-205-5p were analyzed via TCGA. Real Time Quantitative PCR employed determine the different...
In China, private-owned cooperatives are becoming increasingly involved in agricultural production. order to find the key characteristics of smallholders’ social networks after appearance and better organize different farmland operators, this study completed a field survey 114 smallholders who adopted trusteeship service cooperative China applied network analysis reveal following results. (1) Compared theoretical ideal value, showed low density, efficiency, little relevancy. (2)...
Given the limitations of backpropagation, perturbation-based gradient computation methods have recently gained focus for learning with only forward passes, also referred to as queries. Conventional consumes enormous queries on each data point accurate estimation through Monte Carlo sampling, which hinders scalability those algorithms. However, not all points deserve equal estimation. In this paper, we study problem improving efficiency from a novel perspective: how reduce variance minimum...