A5070341270- Immune cells in cancer
- Dietary Effects on Health
- Gut microbiota and health
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- Cancer Immunotherapy and Biomarkers
- Palliative Care and End-of-Life Issues
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Cancer survivorship and care
- MicroRNA in disease regulation
- Family Support in Illness
- Cancer, Stress, Anesthesia, and Immune Response
- Autoimmune and Inflammatory Disorders Research
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Parvovirus B19 Infection Studies
- CAR-T cell therapy research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Kruppel-like factors research
- Blood disorders and treatments
- Plant Disease Resistance and Genetics
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Zhongshan Hospital
2023-2024
Fudan University
2021-2024
Sun Yat-sen University
2023-2024
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
Nantong University
2023-2024
Shanghai First People's Hospital
2024
Songjiang District Central Hospital
2024
Shanghai Jiao Tong University
2024
Lysosomes are one of the major centers for regulating cargo degradation and protein quality control. Transcription factor EB (TFEB)-promoted lysosome biogenesis enhances lysosome-mediated alleviates neurodegenerative diseases, but mechanisms underlying TFEB modification activation still poorly understood. Here, we report essential roles acetylation in nuclear translocation biogenesis, which independent dephosphorylation. By screening small molecules, find that Trichostatin A (TSA),...
As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal cancer. Single-cell RNA...
Abstract Background In recent years,the lack of specific markers for the diagnosis colorectal cancer has led to an upward trend in both morbidity and mortality from this condition. There is urgent need identify molecular biomarkers that contribute early detection. This study aimed exosomal microRNAs hold potential as diagnostic CRC. Methods We screened differentially expressed miRNAs using CRC exosome dataset GSE39833. To validate results public database, we collected serum 168 patients...
Pancreatic adenocarcinoma (PAAD) remains challenging to diagnose and treat clinically due its difficult early diagnosis, low surgical resection rate, high risk of postoperative recurrence metastasis. SMAD4 is a classical mutated gene in pancreatic cancer lost up 60%-90 % PAAD patients, mutation often predicts poor prognosis treatment resistance. In this study, based on the expression profile data The Cancer Genome Atlas database, we identified ceRNA network composed 2 lncRNAs, 1 miRNA, 4...
Gastrointestinal cancers, including gastric and colorectal are major contributors to cancer-related morbidity mortality worldwide, placing significant burdens on patients their informal caregivers. This study aims evaluate the level of supportive needs among caregivers with gastrointestinal cancer identify key factors influencing these needs. We conducted a descriptive survey involving 335 at large hospital in Shanghai, China, from September 2023 April 2024. Multivariate linear regression...
Abstract Colorectal cancer is a common malignant tumor, whose growth and metastasis are influenced by numerous factors. MicroRNAs have garnered increasing attention in recent years due to their involvement tumor development. Exosomes involved intercellular signaling influence development promoting cell proliferation through activation of angiogenesis other mechanisms. This study aimed investigate how the exosomes containing miR-320d from colorectal (CRC) cells promote regulating...
Millions of people are suffering from Alzheimer's disease globally, but there is still no effective treatment for this neurodegenerative disease. Thus, novel therapeutic approaches needed, which requires further evaluation the regulatory mechanisms protein aggregate degradation. Lysosomes crucial degradative organelles that maintain cellular homeostasis. Transcription factor EB-mediated lysosome biogenesis enhances autolysosome-dependent degradation, subsequently alleviates diseases,...
As immune checkpoint inhibitors have shown good clinical efficacy, blockade has become a vital strategy in cancer therapy.However, approximately only 12.5% patients experience benefits from immunotherapy.Herein, we identified the differentiation inducer chlorogenic acid (CGA, now phase II trial China for glioma treatment) to be small-molecular inhibitor that boosted antitumor effects of anti-PD-1 antibody.CGA suppressed expression PD-L1 induced by interferon-γ tumor cell culture through...
Neurodegenerative diseases are characterized by neuron loss and accumulation of undegraded protein aggregates. These phenotypes partially due to defective degradation in neuronal cells. Autophagic clearance aggregated proteins is critical quality control, but the underlying mechanisms still poorly understood. Here we report essential role WDR81 autophagic aggregates models Huntington’s disease (HD), Parkinson’s (PD) Alzheimer’s (AD). In hippocampus cortex patients with HD, PD AD, level...
<title>Abstract</title> <bold>Purpose:</bold> Despite the growing body of research on cancer patient caregivers, unique experiences spouses caring for elderly colorectal patients remain underexplored. This study aimed to fill this gap by examining caregiving during palliative chemotherapy Chinese patients. <bold>Methods:</bold> Using a qualitative descriptive design, we recruited spousal caregivers undergoing chemotherapy. Semistructured interviews were conducted, and thematic analysis was...
<title>Abstract</title> PD-1 blockade is essential in treating progressive colorectal cancer (CRC). However, some CRC patients do not respond well to immunotherapy, possibly due the exhaustion of CD8<sup>+</sup> T cells tumor microenvironment. Acetylcysteine (NAC) can reduce cell vitro and induce their differentiation into long-lasting phenotypes, thus enhancing anti-tumor effect adoptive transfer. whether NAC be combined with treatment how regulates remains unclear. We demonstrated that...
Immunogenic cell death (ICD) is a functionally specialized form of apoptosis induced by endoplasmic reticulum (ER) stress and associated with variety cancers, including gastric cancer (GC). In recent years, long non-coding RNAs (lncRNAs) have been shown to be important mediators in the regulation ICD. However, specific role prognostic value ICD-related lncRNAs GC remain unclear. This study aims develop an signature for risk assessment GC.
Programmed cell death protein 1 (PD-1) blockade is essential in treating progressive colorectal cancer (CRC). However, some patients with CRC do not respond well to immunotherapy, possibly due the exhaustion of CD8
<p>Supplemental materials and methods</p>
<div>Abstract<p>As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal...
<p>Supplemental materials and methods</p>
<p>Supplementary figures and tables</p>