A5012593699- Dietary Effects on Health
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutrition, Genetics, and Disease
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Cancer, Stress, Anesthesia, and Immune Response
- Aortic aneurysm repair treatments
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Ferroptosis and cancer prognosis
- Psychosomatic Disorders and Their Treatments
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Traumatic Brain Injury Research
- Immune Cell Function and Interaction
- Infectious Aortic and Vascular Conditions
- Acupuncture Treatment Research Studies
Zhongshan Hospital
2021-2025
Fudan University
2021-2025
Sun Yat-sen University
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Shanghai Medical College of Fudan University
2025
Shandong Provincial Hospital
2024
Zunyi Medical University
2024
Fudan University Shanghai Cancer Center
2020
Abstract S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to the S100 family of calcium-binding proteins and plays a role in variety inflammatory diseases. Although S100a8/a9 has been reported trigger endothelial cell apoptosis, mechanisms S100a8/a9-induced dysfunction during sepsis require in-depth research. We demonstrate that high expression levels suppress Ndufa3 mitochondrial complex I via downregulation Nrf1 expression. Mitochondrial deficiency contributes...
Neutrophil extracellular traps (NETs) assist pathogen clearance, while excessive NETs formation is associated with exacerbated inflammatory responses and tissue injury in acute lung (ALI)/acute respiratory distress syndrome (ARDS). Autophagy generally considered to be a protective process, but autophagy dysfunction harmful. Whether how affect autophagic flux during sepsis-induced ALI are currently unknown. Here, we confirmed that the level of was increased ARDS patients mice models, which...
As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal cancer. Single-cell RNA...
Background: Pancreatic cancer is very susceptible to metastasis with a high mortality. Neutrophil extracellular traps (NETs) have been reported be associated poor prognosis in patients suffering from pancreatic cancer. However, the underlying mechanisms by which NETs facilitate progression remain poorly understood. Methods: The expression of was assessed tissues and plasma samples patients. Neutrophils were isolated blood individuals diagnosed evaluate formation. impact on cells...
The excessive formation and release of neutrophil extracellular traps (NETs) in sepsis may represent a substantial mechanism contributing to multiorgan damage, which is associated with poor prognosis. However, the precise role NETs mediating transition from innate immunity adaptive during progression inflammation remains incompletely elucidated. In this study, we provide evidence that, despite reduction number CD4+ T cells late stage sepsis, there notable upregulation proportion Tregs....
Background . Hepatocellular carcinoma (HCC) is a life-threatening cancer, and the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) signalling pathway plays crucial role in apoptosis resistance cancer cells. Fasting reported to mediate tumour growth reduction apoptosis. SET8 involved proliferation, invasiveness, migration. However, whether participates fasting-mediated HCC remains unclear. Methods We used immunohistochemical staining...
Abstract Type A aortic dissection (AD) is a catastrophic cardiovascular disease. Hypoxia‐inducible factor‐1α (HIF‐1α) and autophagy are reported to be upregulated in the AD specimens. However, interaction between HIF‐1α pathogenesis of remains explored. LC3 levels evaluated 10 normal MDC staining, autophagic vacuoles, flux detected human smooth muscle cells (HASMCs) under hypoxia treatment. CCK‐8, transwell, wound healing assay used identify proliferation migration Furthermore, 3‐MA inhibit...
NXPH4 promotes cancer proliferation and invasion. However, its specific role mechanism in remain unclear. Transcriptome clinical data for pan-cancer were derived from the TCGA database. K-M survival curve univariate Cox used prognostic analysis. CIBERSORT TIMER algorithms employed to calculate immune cell infiltration. Gene set enrichment analysis (GSEA) was investigating function of NXPH4. Western blot verified differential expression colon cancer. Functional assays (CCK-8, plate...
<title>Abstract</title> <bold>Objective</bold> This study aimed to investigate the effects of <italic>Xingnao Kaiqiao </italic>(XNKQ)<italic> </italic>needling method and combined with <italic>Shixuan</italic> <italic>Yongquan </italic>points (XNKQSY needling method) on brain function in patients different levels consciousness. <bold>Methods</bold> Thirty-three disorders consciousness (DOCs) were divided into minimally conscious state (MCS) (n=16) unresponsive wakefulness syndrome (UWS)...
<p>Supplemental materials and methods</p>
<div>Abstract<p>As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal...
<p>Supplemental materials and methods</p>
<p>Supplementary figures and tables</p>
<div>Abstract<p>As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD) exhibits excellent antitumor efficacy by regulating metabolism boosting immunity. A better understanding of the specific mechanisms underlying immunoregulatory functions FMD could help improve expand clinical application FMD-mediated immunotherapeutic strategies. In this study, we aimed to elucidate role metabolic reprogramming induced in activation immunity against colorectal...
<p>Supplementary figures and tables</p>