A5108712382- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Cutaneous lymphoproliferative disorders research
- Chronic Lymphocytic Leukemia Research
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
- Cardiac Valve Diseases and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrhythmias and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- CAR-T cell therapy research
- Cardiac pacing and defibrillation studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Digital Imaging for Blood Diseases
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Tulane University
2024-2025
Chinese University of Hong Kong
2025
Nanjing Drum Tower Hospital
2025
Union Hospital
2019-2024
Jilin University
2019-2024
Peking Union Medical College Hospital
2020-2024
Zhongshan Hospital
2024
Fudan University
2024
Sun Yat-sen University
2024
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease characterized by aggressive and symmetric polyarthritis. Mammalian target of rapamycin (mTOR) was reported to be new for RA therapy its inhibitor can significantly reduce the invasive force fibroblast-like synoviocytes. Here, we determined effect curcumin alleviate inflammation synovial hyperplasia RA.
Schnitzler syndrome (SchS) is a rare acquired systemic autoinflammatory disorder, characterized by chronic urticarial rash and immunoglobulin M (IgM) monoclonal gammopathy. Anti-interleukin-1 (IL-1) therapies have been shown to be more effective in managing the clinical symptoms of SchS compared anti-IL-6 therapies. In this case report, we present male patient with rash, fever, arthralgia. Laboratory tests identified presence IgMκ protein, absence IL-1β serum. Whole exome sequencing (WES)...
Our previous studies demonstrated that activated T cells accumulate in perihematomal regions following intracerebral hemorrhage (ICH) and exacerbate hemorrhagic brain injury. In the present study, we aimed to explore mechanisms underlying brain-infiltrating cell activation associated pathophysiological effects neurological outcomes ICH. We employed standardized collagenase injection-induced autologous blood injection models of ICH male C57BL/6J mice. receptor (TCR) activation, immune...
BACKGROUND: Current guidelines recommend implantable cardioverter defibrillators for the primary prevention of sudden cardiac death (SCD) in patients with dilated cardiomyopathy left ventricular ejection fraction (LVEF)≤35%. However, its effectiveness is hindered by inability to reliably discriminate between risk SCD and competing heart failure deterioration, thereby limiting clinical utility. We aimed refine stratification model based on magnetic resonance imaging LVEF≤35%. METHODS: A total...
Abstract Background The role of the dysfunction left atrium in occurrence and development cardiovascular disease has been gradually recognized. We aim to compare impact on atrial (LA) function between patients with hypertrophic cardiomyopathy (HCM) hypertension (HTN) without LA enlargement using magnetic resonance feature tracking (CMR-FT), if possible, explore capability for providing clinical implication predicting adverse events early stage disease. Methods Consecutive 60 HCM HTN normal...
The excessive formation and release of neutrophil extracellular traps (NETs) in sepsis may represent a substantial mechanism contributing to multiorgan damage, which is associated with poor prognosis. However, the precise role NETs mediating transition from innate immunity adaptive during progression inflammation remains incompletely elucidated. In this study, we provide evidence that, despite reduction number CD4+ T cells late stage sepsis, there notable upregulation proportion Tregs....
Background Assessment of subclinical myocardial dysfunction by using feature tracking has shown promise in prognosis evaluation heart failure with preserved ejection fraction (HFpEF). Global early diastolic longitudinal strain rate (eGLSR) can identify earlier dysfunction; however, limited data are available on its prognostic value HFpEF. Purpose To evaluate the association between left ventricular (LV) eGLSR and primary composite outcomes (all-cause death or hospitalization) patients...
Abstract Background Recent findings elucidated hepatic PPARγ functions as a steatogenic-inducer gene that activates de novo lipogenesis, and is involved in regulation of glucose homeostasis, lipid accumulation, inflammation response. This study delved into comprehensive analysis how signaling affects the exercise-induced improvement insulin resistance (IR) non-alcoholic fatty liver disease (NAFLD), along with its underlying mechanism. Methods Chronic acute swimming exercise intervention were...
Abstract Cerebral metabolic dysfunction is a critical pathological hallmark observed in the aftermath of traumatic brain injury (TBI), as extensively documented clinical investigations and experimental models. An in‐depth understanding bioenergetic disturbances that occur following TBI promises to reveal novel therapeutic targets, paving way for timely development interventions improve patient outcomes. The 13 C isotope tracing technique represents robust methodological advance, harnessing...
Abstract Background Diabetic kidney disease (DKD) makes up nearly half of all chronic cases and is a major cause mortality for people with diabetes. However, the study association longitudinal Chinese visceral adiposity index (CVAI) DKD still missing. Methods This prospective cohort included 7874 diabetes patients from Kailuan study. These participants had complete repeated waist circumference, body mass index, triglycerides high‐density lipoprotein cholesterol measurements that formed...
Background: Myocardial fibrosis predicts adverse outcomes in myocardial infarction (MI) and other cardiovascular conditions. Cardiovascular magnetic resonance (CMR) can non-invasively detect focal diffuse fibrosis, but comprehensive validation against histology remains scarce. Aims: To assess the comparative diagnostic performance of CMR methods detecting using a mini-swine model as gold standard. Methods: Eighteen (16 MI; 2 healthy) underwent cine, LGE, T1- ECV-mapping. Two commonly-used...
In patients with acute myocarditis, cardiac MRI−derived native T1 and extracellular volume fraction provided incremental prognostic value for predicting occurrence of major adverse cardiovascular events when combined in a model conventional clinical imaging parameters.
Meniere disease (MD) is a common inner ear disorder closely related to immune abnormalities, but research on the characteristic genes between MD and responses still insufficient. We employ bioinformatics machine learning predict potential biomarkers cells associated with MD, investigating Mendelian randomization causation providing new insight for early diagnosis, prevention, treatment of MD. obtained relevant data from GEO database using R, conducted differential gene analysis, performed...
Background Considering that 30% to 40% of patients do not benefit from cardiac resynchronization therapy implantation, it is insufficient evaluate with heart failure reduced ejection fraction solely based on QRS duration and morphology for guiding decisions prognosis. A crucial step in addressing this issue conducting a comprehensive pathophysiological assessment understand the mechanisms underlying dyssynchrony inefficient contraction. This study aims utilize magnetic resonance imaging...
Despite current recommendations for heart failure with preserved ejection fraction (HFpEF), few studies have demonstrated the ability of MRI to identify subtle functional differences between HFpEF essential hypertension (HFpEF-HTN) patients and (HTN).This study aimed detect evaluate in HTN using feature-tracking (FT) ascertain optimal strain cutoffs diagnosis HFpEF-HTN.Retrospective study.Three groups (84 HFpEF-HTN; 72 HTN; 70 healthy controls).1.5T, steady-state free precession (SSFP),...
Subclinical hypothyroidism is known to increase the risk of cardiovascular diseases and mortality. However, longitudinal association between subclinical incident metabolic syndrome remains unclear.A total 3615 participants from Beijing Health Management Cohort were enrolled 2012 2014 followed through 2019. People placed into euthyroidism groups according serum-free thyroxine TSH concentrations. We used Cox proportional hazards regression models investigate relationship level considering...
Background Studies over the past 15 years have demonstrated that a considerable number of patients with dilated cardiomyopathy (DCM) who died from sudden cardiac death (SCD) had left ventricular (LV) ejection fraction (LVEF) 35% or higher. Purpose To identify clinical and MRI risk factors for adverse events in DCM LVEF Materials Methods In this retrospective study, consecutive higher underwent between January 2010 December 2017 were included. The primary end point was composite SCD aborted...
Abstract The clinical features, CMR characteristics and outcomes of arrhythmogenic left ventricular cardiomyopathy (ALVC), which is a very rare nonischemic cardiomyopathy, are currently not well studied. purpose the study to investigate cardiovascular magnetic resonance (CMR) imaging (ALVC). Fifty-three consecutive patients with ALVC were divided into two groups: without right (RV) involvement (n = 36, group 1) those RV 17, 2). Clinical symptoms, cardiac electrophysiological findings,...
Abstract Context Nonalcoholic fatty liver disease (NAFLD) has emerged as a public health issue, while no drugs have been specifically approved for treatment. Objective This study aimed to examine the association between statin use and NAFLD occurrence, progression, regression. Methods A cohort was designed based on Kailuan Study electronic medical records from General Hospital. Participants aged 18 years with indication, including nonstatin users, were enrolled 2010 2017. Propensity score...