A5101549643- RNA modifications and cancer
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Tuberous Sclerosis Complex Research
- Vascular Tumors and Angiosarcomas
- Breast Lesions and Carcinomas
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Soft tissue tumor case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Impact of AI and Big Data on Business and Society
- Cutaneous lymphoproliferative disorders research
- Curcumin's Biomedical Applications
- vaccines and immunoinformatics approaches
- Chemical Reactions and Isotopes
- Heat shock proteins research
Nantong University
2015-2024
Taizhou People's Hospital
2015-2024
Nanjing Medical University
2023-2024
China University of Geosciences
2024
Liaocheng People's Hospital
2017-2022
Hubei University of Science and Technology
2022
Hunan University of Technology
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2005
Abstract The outbreak of a novel febrile respiratory disease called COVID-19, caused by newfound coronavirus SARS-CoV-2, has brought worldwide attention. Prioritizing approved drugs is critical for quick clinical trials against COVID-19. In this study, we first manually curated three Virus-Drug Association (VDA) datasets. By incorporating VDAs with the similarity between and that viruses, constructed heterogeneous network. A Random Walk Restart method (VDA-RWR) was then developed to identify...
Curcumin is a natural compound extracted from the dried rhizomes of Curcuma (curcuma root or zedoary) that exhibits extensive pharmacological effects and low toxicity. The aim present study was to investigate whether curcumin inhibits cell proliferation promotes apoptosis laryngeal cancer through Bcl-2 phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), by upregulating microRNA-15a (miR-15a). It demonstrated proliferation, increased caspase-3 activity human cells. Furthermore, decreased...
Abstract Background It is of great concern to identify prognostic signatures for the prediction and esophageal squamous cell carcinoma (ESCC), which lethal pathological type malignancy. Method Bulk RNA sequencing scRNA-seq data were retrieved from GSE53624, GSE53622, GSE188900. Disulfidptosis-related differentially expressed genes (DEGs) identified between disulfidptosis-high score disulfidptosis-low groups. Functional annotation DEGs analyzed by Gene Ontology (GO). Consistent clustering...
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance epithelial growth factor receptor (EGFR) Kirsten rat sarcoma viral oncogene (KRAS) mutations prognosis PPMA. A total 29 patients with PPMA from among 1,469 surgically resected were enrolled. All tumours expressed CK7 5 cases exhibited co-expression CK20. 8 EGFR, 14 P53 2 CEA....
Pancreatic adenocarcinoma (PAAD) remains challenging to diagnose and treat clinically due its difficult early diagnosis, low surgical resection rate, high risk of postoperative recurrence metastasis. SMAD4 is a classical mutated gene in pancreatic cancer lost up 60%-90 % PAAD patients, mutation often predicts poor prognosis treatment resistance. In this study, based on the expression profile data The Cancer Genome Atlas database, we identified ceRNA network composed 2 lncRNAs, 1 miRNA, 4...
Peritoneal metastasis is one of the main causes death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors GC and may be key peritoneal metastasis. In this study, we elucidated regulatory role galectin-1 cell tissues underwent hematoxylin-eosin (HE), immunohistochemical (IHC), Masson trichrome staining to analyze difference expression collagen deposition different clinical stages. The adhesion mesenchymal cells was determined using HMrSV5 human...
BACKGROUND:Protocadherin 8 (PCDH8) functions as a tumor-suppressor gene in many types of cancer. This study aimed to investigate the role PCDH8 esophageal squamous cell carcinoma (ESCC). MATERIAL AND METHODS:Cell proliferation, apoptosis, transwell assay, tube formation assays, and tumor xenograft experiment were performed explore progression ESCC. RESULTS:PCDH8 was found be downregulated ESCC cells. Ectopic expression blocked invasion, migration induced apoptosis Furthermore, vascular...
Recently, many researches demonstrated that microRNAs (miRNAs) are new small molecule drug targets. Identifying molecule-miRNA associations (SMiRs) plays an important role in finding clues for various human disease therapy. Wet experiments can discover credible SMiR associations, however, it is costly and time-consuming. Therefore, computational models developed to uncover possible associations. In this study, we designed a association prediction model, RWNS. RWNS integrated biological...
Considering the essential role of plakophilin 3 (PKP3) in maintenance cell-cell adhesion, dysregulation PKP3 is involved human diseases. This study aimed to explore clinical significance ovarian cancer. Immunohistochemistry was performed examine expression 157 cancer specimens from primary patients. expressed both cytoplasm and nucleus. Eighty-one (51.6%) out tissues showed expression, while absent observed normal tissues. High associated with lymph node metastasis (LNM, P = .004) advanced...
Galectin-1 (Gal1) and non-SMC condensin I complex, subunit G (NCAPG) are associated with metastasis in several malignant tumors. However, their precise roles gastric cancer (GC) remain uncertain. This study explored the clinical significance relationship of Gal1 NCAPG GC. expressions were significantly up-regulated GC compared to adjacent non-cancerous tissues by immunohistochemistry (IHC) Western blotting. Besides, methods including stable transfection, quantitative real-time reverse...
Abstract Introduction: Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to thyroid carcinoma and the abnormal expression of transcription factor-1 (TTF-1). We herein report case TL-LGNPPA with review its clinical characteristics treatment provided. Patient concerns Diagnosis: The patient was 50-year-old Chinese woman complaint three-year history phlegm blood pharyngeal discomfort. There were no remarkable...
Angiomyolipoma is an extremely rare, benign mesenchymal tumor of the nasal cavity, primarily common in kidney and secondarily liver. According to author's knowledge, no cases angiomyolipoma septum have been identified date. We report a case patient with giant at posterior end who recovered after surgery without any complication.
摘要: 患者男,50岁,因右肩部反复发生肿物30年、再次发现肿物3个月于2021年4月就诊。1991年患者20岁时初次发现右肩部1个黄豆大小、凸出的肿物,同年7月10日在泰州人民医院紧贴肿物边缘切除,术后病理诊断"纤维瘤"……
Background Carcinosarcoma is a rare esophageal tumor, accounting for approximately 0.27-2.8% of malignant tumors. This study aims to investigate the clinical pathological characteristics, surgical treatment outcomes, and analysis prognostic factors in carcinosarcoma (ECS). Methods Clinical data from sixteen patients diagnosed with sarcomatoid carcinoma who underwent interventions were retrospectively analyzed. features, modalities, postoperative outcomes systematically examined. Results Out...