A5100644257- Colorectal Cancer Screening and Detection
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Medical Research and Treatments
- Cancer, Hypoxia, and Metabolism
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- RNA Research and Splicing
- Acupuncture Treatment Research Studies
- Bone and Dental Protein Studies
- Curcumin's Biomedical Applications
- Autoimmune and Inflammatory Disorders Research
- Piperaceae Chemical and Biological Studies
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Bowel Disease
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2014-2024
First Affiliated Hospital of Henan University
2024
Baotou Medical College
2023
Chongqing Cancer Hospital
2023
Chongqing University
2023
Yichang Central People's Hospital
2021
China Three Gorges University
2021
University of Electronic Science and Technology of China
2019
The First Affiliated Hospital, Sun Yat-sen University
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Objective The effect of colonoscopy on colorectal cancer mortality is limited by several factors, among them a certain miss rate, leading to adenoma detection rates (ADRs). We investigated the an automatic polyp system based deep learning rate and ADR. Design In open, non-blinded trial, consecutive patients were prospectively randomised undergo diagnostic with or without assistance real-time providing simultaneous visual notice sound alarm detection. primary outcome was Results Of 1058...
As more is learned about lactate, it acts as both a product and substrate functions shuttle system between different cell populations to provide the energy for sustaining tumor growth proliferation. Recent discoveries of protein lactylation modification mediated by lactate play an increasingly significant role in human health (e.g., neural osteogenic differentiation maturation) diseases tumors, fibrosis inflammation, etc.). These views are critically first described detail this review....
MicroRNAs (miRNAs) play important roles in the growth and metastasis of colon cancer. It is known that one set miRNAs are dysregulated cancer cells, but mechanism their role development still largely unknown. Our study focuses on miR-378 cells. Human tissues adjacent non-tumor were collected from patients diagnosed pathological examinations. In addition, human cell lines LoVo, CaCo2, SW1116, SW480 HCT-116, a normal colonic mucosa line NCM460 included. Quantitative RT-PCR was used to detect...
Computer-aided detection (CADe) of colon polyps has been demonstrated to improve polyp and adenoma during colonoscopy by indicating the location a given on parallel monitor. The aim this study was investigate whether embedding CADe system into primary monitor may serve increase detection, without increasing physician fatigue level.Consecutive patients presenting for colonoscopies were prospectively randomized undergo routine with or assistance real-time system. Fatigue level evaluated from...
Non-alcoholic fatty liver disease (NAFLD) has been considered as a multi-factorial metabolic syndrome. MicroRNA-375 (MiR-375) was significantly up-regulated in serum of NAFLD patients and the role miR-375 addressed putative biomarker progression. However, specific function progression is still unclear molecular mechanisms underlying have yet to be elucidated. Our study aimed at investigating regulatory pathogenic find out whether regulates expression level adipokines inflammatory cytokines...
Akkermansia muciniphila is considered the “paradigm for next-generation beneficial microorganisms” and has been reported to help alleviat immune-related diseases. Evidence shows that herbal medicine can treat disease by regulating abundance of A. . Recent studies have revealed a link between Here, we systematically reviewed association , medicine, diseases (including inflammatory bowel disease, human immunodeficiency virus, cancer immunotherapy, liver injury). We also summarize potential...
Evidence has shown that deep learning computer aided detection (CADe) system achieved high overall accuracy for polyp during colonoscopy.The performance of CADe on non-polypoid laterally spreading tumors (LSTs) and sessile serrated adenomas/polyps (SSA/Ps), with higher risk malignancy transformation miss rate, not been exclusively investigated.A previously validated was tested LSTs SSA/Ps. 1451 LST images from 184 patients were collected between July 2015 January 2019, 82 SSA/Ps videos 26...
Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM formation of de novo vascular networks by highly invasive tumor cells, instead endothelial cells. An understanding mechanisms will contribute to targeted therapy GBMs. present study, efficacy curcumin (CCM) on its were investigated. It was that CCM inhibits formation, proliferation, migration invasion human glioma U251...
To study the relationship between non-alcoholic steatohepatitis (NASH) and atherosclerosis in young middle-aged patients, to provide clinical evidence that will aid prevention prediction of development or cardiovascular diseases patients with fatty liver disease (NAFLD).Fifty-one biopsy-proven NAFLD (18 60 years age) were divided into two groups: cases simple (NAFL, n = 11) NASH (n 40). All subjects underwent physical examination anthropometric measurements. Fasting serum was assayed by...
The biological function of circular RNA 0000514 (circ_0000514) in breast cancer (bc) is still unknown. In this study, we downloaded the microarray dataset GSE101123 from Gene Expression Omnibus database and then analysed differentially expressed RNAs bc tissues compared with adjacent tissues, demonstrated that circ_0000514 was up-regulated tissues. Circ_0000514, miR-296-5p CXC chemokine ligand10 (CXCL10) expressions cell lines were probed by quantitativereal-time polymerase chain reaction...
The present study aimed to compare the clinical value of multi-band mucosectomy (MBM) versus endoscopic mucosal resection (EMR) for treatment patients with early-stage esophageal cancer. Between January 2011 and December 2012, 68 cancer who underwent MBM EMR were enrolled into study. curative rate, duration surgery, complications follow-up records retrospectively analyzed. Of included, 33 treated 35 EMR. There was no significant difference in rate complete between groups (P>0.05). mean...
Many studies have reported minor complications and disturbance of the gut microbiota after colonoscopy. Compared with air, carbon dioxide (CO2) insufflation could decrease complications, but its impact on remains unknown.Thirty-eight healthy subjects were assessed twenty randomized to receive either CO2 or air during Neither participants nor staff involved in follow-up knew which gas was used. Minor using symptom scores. Fecal samples collected at eight time-points for microbiome analysis by...
The adequate exposure of the ampullary orifice and reliable fixation duodenal papilla are always basic principles successful cannulation during endoscopic retrograde cholangiopancreatography (ERCP). In recent years, several traction strategies have proven to be effective in eversion a hidden within large diverticulum, such as using cannula [1], endobiliary forceps [2], or SpyBite [3] manipulate papilla. However, with above coaxial lifting strategies, it is not possible optionally adjust...
Objective To explore the effect and mechanism of miR-21 down-regulated which was induced by H 2O 2 on osteogenic differentiation MC3T3-E1 cells. Methods cells were cultured passaged, 7th generation harvested to use in experiment. The treated with different concentrations (0, 40, 80, 160, 320 μmol/L) 2. expression detected real-time quantitative PCR (RT-PCR) cell viability determined MTS. Then appropriate concentration obtained. analyze cells, divided into blank control group (group A), B),...
To evaluate the safety and effectiveness of Shenbei Guchang capsules in treatment diarrhea type irritable bowel syndrome (yang deficiency spleen kidney) under widely used conditions, an open, multicenter, controlled, phase Ⅳ clinical trial was conducted drug centers 16 domestic hospitals. 2 123 patients from June 10, 2011 to November 29, 2012 were enrolled trial. Drug approved by Sichuan Academy Medical Sciences, Provincial People's Hospital Ethics Committee before implementation. Before...
Aim: This study was to investigate the diagnostic value by using Liver stiffness measurement (LSM) measured FibroScan in patients with hepatocellular carcinoma (HCC).Methods: There were 48 HCC who underwent LSM (Each patient detected 5 different sites.) between June 2021 and February 2022 enrolled this research.LSM failure defined as zero valid shots (unsuccessful LSM), or ratio of interquartile range median 10 measurements (IQR/M) greater than 0.30 plus success rate (SR) less 60%...