A5039666314- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Total Knee Arthroplasty Outcomes
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Nanomaterials for catalytic reactions
- Genetic factors in colorectal cancer
- Knee injuries and reconstruction techniques
- Digital Media and Visual Art
- Organ Transplantation Techniques and Outcomes
- BRCA gene mutations in cancer
- Neurofibromatosis and Schwannoma Cases
- Congenital Anomalies and Fetal Surgery
- Adolescent and Pediatric Healthcare
- Protease and Inhibitor Mechanisms
- Advancements in Battery Materials
Hebei Normal University of Science and Technology
2024
Jiangsu University
2024
Zhejiang University of Science and Technology
2024
Zhuhai People's Hospital
2022
Jinan University
2014-2022
First Affiliated Hospital of Kunming Medical University
2021
Kunming Medical University
2021
Peking University
2020
Second Affiliated Hospital of Nanchang University
2017-2018
Nanchang University
2017-2018
Transition metal sulfides with designed nanostructures are expected to provide superior electrochemical performance when used as electrode materials for pseudocapacitors compared their oxide counterparts. In this paper, hollow Co 3 S 4 dodecahedra were successfully prepared using cobalt‐based zeolite imidazolium skeleton (ZIF‐67) the precursor and thioacetamide (TAA) sulfur source combined a facile one‐step vulcanization process. The cavity structure not only shortens carrier transport...
Interferon-induced transmembrane protein 3 (IFITM3) has been shown to be overexpressed in multiple cancers. However, the role of IFITM3 metastasis hepatocellular carcinoma (HCC) is still poorly understood. In this study, we showed that was frequently HCC tissues compared with adjacent nontumor tissues. Overexpression significantly correlated tumor and poor prognosis HCC. Knockdown dramatically decreased MMP9 expression inhibited invasion vitro vivo. Moreover, upregulation rescued migration...
Cuproptosis is a novel form of cell death, correlated with the tricarboxylic acid (TCA) cycle. However, metabolic features and benefit immune checkpoint inhibitor (ICI) therapy based on cuproptosis have not yet been elucidated in Hepatocellular carcinoma (HCC). First, we identified validated three subtypes 10 cuproptosis-related genes (CRGs) HCC patients. We explored correlation between metabolism-related pathways. Besides, comprehensive analysis was performed. Then, calculated gene...
The interferon-induced transmembrane protein 3 (IFITM3, also called 1‑8U) gene represents dysregulated expression in various tumors and is involved tumorigenesis progression. However, the role of IFITM3 its underlying mechanism hepatocellular carcinoma (HCC) are still far from elucidated. MicroRNAs (miRNAs), a class endogenous (approximately 22 nucleotides) small noncoding RNAs, can post‑transcriptionally regulate by repressing translation or silencing target genes that play critical roles...
Abstract Background The 5-hydroxymethylcytosine (5hmC) DNA modification is an epigenetic marker involved in a range of biological processes. Its function has been studied extensively tumors, neurodegenerative diseases, and atherosclerosis. Studies have reported that 5hmC closely related to the phenotype transformation vascular smooth muscle cells endothelial dysfunction. However, its role coronary artery disease (CAD) not fully studied. Results To investigate whether correlates with CAD...
Background/Aims: Dysregulation of ubiquitin-associated protein 2-like (UBAP2L) has been reported in tumors, but its role hepatocellular carcinoma (HCC) progression is unclear. Methods: The expression levels UBAP2L HCC tissues and cell lines were detected by western blot quantitative real-time (qRT) PCR. effects on biological traits, including migration invasion, investigated wound healing assay matrigel transwell assay. Simultaneously, the epithelial-mesenchymal transition (EMT) markers...
Conventional clinical detection methods such as CT, urine cytology, and ureteroscopy display low sensitivity and/or are invasive in the diagnosis of upper tract urinary carcinoma (UTUC), a factor precluding their use. Previous studies on biopsy have not shown satisfactory specificity application both gene mutation or methylation panels. Therefore, these unfavorable factors call for an urgent need sensitive non-invasive method UTUC.In this study, total 161 hematuria patients were enrolled...
ABSTRACT Human genome is continuously threatened by endogenous and exogeneous sources of DNA damage, damage repair (DDR) mechanisms are vital for instability cancer prevention. Homologous recombination (HRR) one the most important DDR because its high-fidelity. BRCA1/2 have long been best characterized HRR genes, but other non-BRCA1/2 genes should not be overlooked. In this study, we illustrate that RAD51D an gene in Chinese ovarian patients, from perspectives including prevalence (2.9%...
Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM formation of de novo vascular networks by highly invasive tumor cells, instead endothelial cells. An understanding mechanisms will contribute to targeted therapy GBMs. present study, efficacy curcumin (CCM) on its were investigated. It was that CCM inhibits formation, proliferation, migration invasion human glioma U251...
The aim of this study was to investigate the mechanisms and effects B-cell lymphoma 2 (Bcl-2) on vasculogenic mimicry (VM) human glioma cells. U87 cells were cultured under hypoxic conditions then divided into four groups: Control, 3-(5-hydroxymethyl-2-furyl)-1-benzylindazole (YC-1), ABT-737 YC-1 + ABT-737. These groups treated with corresponding simulators. expression hypoxia-inducible factor-1α (HIF-1α), matrix metalloproteinase (MMP)-2, MMP-14 Bcl-2 in each group determined using a...
Introduction: Each hepatic artery is functionally essential for providing blood supply to the liver, and so are variant arteries. Variant arteries, including accessory right (ARHA) replaced (RRHA) commonly described in literature. However, they usually occur independently. Here, we report an extremely rare case that involved both ARHA RRHA arising from gastroduodenal (GDA) superior mesenteric (SMA), respectively. To date, this situation has never been reported They were preoperatively...
Atypical meningiomas (AM) are WHO grade II tumors with high heterogeneity and invasiveness, which unique in their clinical presentation, imaging, pathology, treatment, prognosis. In 2016, the diagnosis of AM remodified by classification central nervous system World Health Organization (WHO). order to further analyze treatment characteristics AM, diagnosis, surgery follow-up data 6 patients our hospital from January 2016 December 2019 were analyzed retrospectively.The six admitted between...
Currently, the clinical strategy for diagnosis of non-muscle invasive bladder cancer (NMIBC) such as cystoscopy and cytology are and/or with limited accuracy. OncoUrine, a urinary assay mutation methylation biomarkers, have showed high accuracy in detection upper tract carcinoma (UTUC) patients hematuria. The aim this study is to evaluate performance OncoUrine NMIBC patients.In multicenter prospective study, total 203 were enrolled, including 60 present hematuria 143 under recurrence...
Abstract Background: Conventional clinical detection methods such as CT, urine cytology, and ureteroscopy display low sensitivity and/or are invasive in the diagnosis of upper tract urinary carcinoma (UTUC), a factor precluding their use. Previous studies on biopsy have not shown satisfactory specificity application both gene mutation or methylation panels. Therefore, these unfavorable factors call for an urgent need sensitive non-invasive method UTUC. Methods: In this study, total 161...
To investigate the molecular mechanism of defense response "Cabernet Sauvignon" grapes to feeding by
e16509 Background: At present, bladder cancer is diagnosed mainly through cystoscopy as the "gold standard" method, which invasive, costly, and painful for patients. Meanwhile, current non-invasive liquid biopsy approaches, such FISH or cytology, still do not show adequate performance in diagnosis of because unsatisfactory sensitivity. Therefore, developing a novel method that performs higher sensitivity specificity, especially negative predictive value(NPV) an urgent issue to be addressed...
Objective To study the hemodialysis filtration effect on inflammatory state of patients.Methods We selected 30 cases maintenance (MHD) patients in room,and randomly divided them into observation group and control (n=15).Observation was treated with combined filtration,the hemodialysis,then observed recorded improvement conditions ALb,BUN,Scr,IL-6,TNF alpha hs-CRP levels two groups.Results 12 weeks after treatment IL-6,TNF alpha,hs-CRP were significantly lower than those group,ALb propagated...
Objective: To observe the mid-term clinical outcome of total knee arthroplasty (TKA) with domestic A3 posterior stabilized prosthesis. Methods: The data 342 patients (438 knees) who underwent primary TKA by same surgeon from June 2012 to December 2013 in Peking University Third Hospital were retrospectively collected. divided into 2 groups according type prosthesis: 107 (137 prosthesis, as group; 235 (301 a kind imported control group. In end, 311 (390 received complete follow-up.The...
Abstract Background: Upper tract urinary carcinoma (UTUC) includes renal pelvic cancer and ureteral cancer. For its diagnosis, ureteroscopy is the only method to obtain pathological result before surgery. However, there are also some problems with ureteroscopy. In addition trauma infection risks, possibility of exudation adhesion surrounding tissues after significantly increased, hypertension in cavity may cause tumor spread, use biopsy recurrence bladder tumors These unfavorable factors...
Abstract Background: There is still some limitations for the diagnosis of urinary cancers, such as invasiveness cystoscopy and ureteroscopy, requirements experienced experts in interpreting images, low sensitivity cytology FISH, great economic pressure long-term monitoring, etc. Thus, there an urgent need accurate, less-expensive, non-invasive method cancers. Previously, A Genetron Urinary Assay were developed, which showed good performances upper urothelial cancer bladder cancer. In...