A5103238312- HIV Research and Treatment
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Ubiquitin and proteasome pathways
- Hepatitis B Virus Studies
- Cardiac electrophysiology and arrhythmias
- Cytokine Signaling Pathways and Interactions
- Molecular Sensors and Ion Detection
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Luminescence and Fluorescent Materials
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Carbohydrate Chemistry and Synthesis
- Endoplasmic Reticulum Stress and Disease
- Magnolia and Illicium research
- RNA regulation and disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sphingolipid Metabolism and Signaling
- Connexins and lens biology
- Ginkgo biloba and Cashew Applications
- Ultrasound and Hyperthermia Applications
Fudan University
2016-2024
Minhang District Central Hospital
2016-2023
Shanghai Municipal Commission of Health and Family Planning
2023
Shangri-la Institute
2021
Beijing Hospital
2016-2018
Zhongshan Hospital
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2017
Indiana University – Purdue University Indianapolis
2016
Indiana University School of Medicine
2016
Wenzhou Medical University
2009-2016
Activity-dependent changes in protein synthesis modify synaptic efficacy. One mechanism that regulates mRNA translation the synapto-dendritic compartment is cytoplasmic polyadenylation, a process controlled by CPEB, polyadenylation element (CPE)-specific RNA binding protein. In neurons, very few mRNAs are known CPEB substrates, and none appear to be responsible for effects on plasticity found knockout mouse. These results suggest of other regulated CPEB. To identify them, we have developed...
Combination therapy (lenvatinib/programmed death-1 inhibitor) is effective for treating unresectable hepatocellular carcinoma (uHCC). We reveal that responders have better overall and progression-free survival, as well high tumor mutation burden special somatic variants. analyze the proteome metabolome of 82 plasma samples from patients with (HCC; n = 51) normal controls (n 15), revealing individual differences outweigh treatment differences. Responders exhibit enhanced activity in...
Honokiol, a well-tolerated natural product, can inhibit the proliferation of cancer cells. But its water insolubility hampers systemic administration for therapy cancer. As drug delivery system, pegylated liposome (PEGL) increase solubility and targeting drug. Honokiol has been successfully encapsulated by PEGL in our laboratory. We wondered whether combination treatment with liposomal honokiol (H-PEGL) cisplatin (DDP) could improve antitumor efficacy ovarian carcinoma. H-PEGL introduce...
Background/Aims: Dysregulation of ubiquitin-associated protein 2-like (UBAP2L) has been reported in tumors, but its role hepatocellular carcinoma (HCC) progression is unclear. Methods: The expression levels UBAP2L HCC tissues and cell lines were detected by western blot quantitative real-time (qRT) PCR. effects on biological traits, including migration invasion, investigated wound healing assay matrigel transwell assay. Simultaneously, the epithelial-mesenchymal transition (EMT) markers...
Gastric cancer (GC) is one of the most common causes cancer-related deaths worldwide, and chemotherapy still a standard strategy for treating patients with advanced GC. Lipid metabolism has been reported to play an important role in carcinogenesis development However, potential values lipid-metabolism-related genes (LMRGs) concerning prognostic value prediction responsiveness GC remains unclear. A total 714 stomach adenocarcinoma were enrolled from Cancer Genome Atlas (TCGA) Gene Expression...
Background: Autophagy plays an important role in cardiovascular disease. Controversy still exists regarding the effect of autophagy on ischemic/hypoxic myocardium. Cardiac shock wave therapy (CSWT) is effective alternative treatment for refractory ischemic heart Whether CSWT can regulate cardiomyocyte under hypoxic conditions not clear. We established a myocardial hypoxia model using H9c2 cell line and performed waves (SWs) to evaluate SW autophagy. Methods: The cells were incubated...
Researches have showed that cardiac shock wave therapy (CSWT) could improve left ventricular function and attenuate LV remodeling of the ischemic heart. Apoptosis plays an important role in myocardial infarction determines heart prognosis. However, it is still not clear whether CSWT sufficient to acute (AMI) induced cardiomyocyte apoptosis vivo. In this study, we used a rat model examine after AMI explore potential mechanisms.We generated investigate possible regulatory mechanisms CSWT. All...
Extracorporeal cardiac shock wave therapy (CSWT) has been used to treat patients with severe coronary heart disease and failure good results; however, the safety of this treatment is still controversial. Its in clinical setting on microstructures confirmed, but influence ultrastructures myocardial cells not clear. In study, 12 Sprague-Dawley rats were randomly divided into control (NC) CSWT (NC+SW) groups. The rate, blood pressure, serum troponin I (TNI), ultrasound evaluated, inflammatory...
Tumor-associated antigens (TAAs) trigger a TAA-specific immune response, thus they are the crux of antitumor immunosurveillance. A major advance in tumor immunology last 20 years was marked by verification that CTL or B-cell epitopes rather than integral TAAs induce immunoreactivity. Previous studies on correlation between heparanase (Hpa) expression and clinical pathological features have generally used commercial antibodies against full-length Hpa protein functional epitopes, antigen...
Autoimmune manifestations are common in human immunodeficiency virus (HIV) patients. However, the autoantibody spectrum associated with HIV infection and impact of antiretroviral therapy (ART) remains to be determined. The plasma for patients was characterized by protein microarrays containing 83 autoantigens confirmed enzyme-linked immunosorbent assay (ELISA). Regulatory T cells (Tregs) myeloid-derived suppressor (MDSCs) were analyzed flow cytometry their effects on autoantibodies...
The purpose of this study was to investigate the expression profile long non-coding RNA (lncRNA) MT1JP in hepatocellular carcinoma (HCC), and explore relationship between its level clinical indicators, as well prognosis HCC patients.In study, 45 pairs tumor tissue specimens paracancerous ones collected from patients were examined through quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) method, interplay patients, also analyzed. Meanwhile, cell lines further verified by qRT-PCR. In...
GH stimulates the phosphorylation of tyrosine residues in receptor (GHR), Janus kinase 2 (JAK2), and other signaling proteins a transient manner that subsides within 1 h. To assess possible roles cytokine-induced Src homology domain (SH2) (CIS/SOCS) these responses, we studied expression disposition CIS/SOCS rat adipocytes, physiological target action. A tyrosine-phosphorylated protein appears to be GHR was coprecipitated from extracts GH-treated adipocytes with α-CIS. In contrast, no...
Inhibiting vascular endothelial foam is the focus of clinical attention. Using SonoVue (an ultrasound contrast agent), salusin- α gene was transfected into arterial intima an atherosclerotic rabbit model induced by a high-fat diet in this study. Subsequently blood lipid indexes, pathological structure intima, and changes molecules regulating atherosclerosis were investigated. The high-density lipoprotein C apolipoprotein A values overexpression (P) group higher than those interference (RP) (...
Historically, coinfection of HIV and hepatitis C virus (HCV) was frequent among Chinese former blood donors (FBDs). This is largely due to ignorance/lack education regarding appropriate sterilizing techniques and/or the availability single-use needles equipment. Although HCV shares identical transmission routes with HIV, source in donor population still remains unknown. In this study, we investigated evolution FBD group. Similar previous reports, two subtypes (HCV 1b 2a) one subtype (Thai-B)...
Unsymmetrical pentamethine cyanine fluorophores were developed and used to visualize physiological acidities from the whole-animal cellular scale with pH-responsive deep-red fluorescence.
Honokiol, a well-tolerated natural product, can inhibit the proliferation of cancer cells. But its water insolubility hampers systemic administration for therapy cancer. As drug delivery system, pegylated liposome (PEGL) increase solubility and targeting drug. Honokiol has been successfully encapsulated by PEGL in our laboratory. We wondered whether combination treatment with liposomal honokiol (H-PEGL) cisplatin (DDP) could improve antitumor efficacy ovarian carcinoma. H-PEGL introduce...
Although antiretroviral therapy (ART) is effective at suppressing the human immunodeficiency virus type 1 (HIV-1) replication, HIV-1 infection still a global public health problem. accessory protein viral R (Vpr) multifunctional with primary role in regulating cellular apoptosis.[1] The amino acid (aa) positions 52–96 C-terminus of Vpr were identified as apoptosis-regulating domain.[2,3] In this study, we found natural variant truncated 54 aa position (∗54Vpr) from HIV patients acquired...
Objective To evaluate the safety of Cardiac Shock Wave Therapy (CSWT) on normal rat heart. Methods Twelve rats were randomly divided into control group (NC, n=6) and (SW) treated (NC+ SW, n=6). All animals sacrificed 24 hours after SW treatment to collect specimens.Hematoxylin eosin (HE) staining was used for histopathology examination, cell apoptosis rate determined by TUNEL staining.Apoptosis related proteins expression analyzed Western blotting. Results HE revealed that there...