A5013148123- Nanoparticle-Based Drug Delivery
- Fullerene Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- ATP Synthase and ATPases Research
- Mesoporous Materials and Catalysis
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Essential Oils and Antimicrobial Activity
- Lipid Membrane Structure and Behavior
- Clay minerals and soil interactions
- Free Radicals and Antioxidants
- Adsorption and biosorption for pollutant removal
- Rabbits: Nutrition, Reproduction, Health
- Chemotherapy-induced cardiotoxicity and mitigation
- Microbial Metabolism and Applications
- Flavonoids in Medical Research
- Plant Toxicity and Pharmacological Properties
- Nitric Oxide and Endothelin Effects
Shanghai University
2022-2025
Jiamusi University
2021
Chinese Academy of Sciences
2017-2020
Center for Excellence in Education
2017-2020
Beijing National Laboratory for Molecular Sciences
2017-2020
Institute of Chemistry
2019-2020
University of Chinese Academy of Sciences
2017-2020
University of Oxford
2020
Jinzhou Medical University
2009-2017
China Agricultural University
2015-2017
Abstract: Naringenin (NRG), a flavonoid compound, had been reported to exhibit extensive pharmacological effects, but its water solubility and oral bioavailability are only ~46±6 µg/mL 5.8%, respectively. The purpose of this study is design develop NRG-loaded solid lipid nanoparticles (NRG-SLNs) provide prolonged sustained drug release, with improved stability, involving nontoxic nanocarriers, increase the by means pulmonary administration. Initially, group contribution method was used...
In this study, we developed a lipid-coated hollow calcium phosphate (LCP) nanoparticle for the combined application of two chemotherapeutic drugs to human lung cancer A549 cells. Hydrophilic doxorubicin (DOX) was incorporated into structure (HCP), and lipid bilayer containing hydrophobic paclitaxel (PTX) subsequently coated on surface HCP. The study combinational effects demonstrated that combination DOX PTX at mass ratio 12:1 showed synergistic effect against particle size, zeta potential,...
This work aimed to develop a sustained release solid dispersion of ivermectin (IVM-SD) in lipid matrix (hydrogenated castor oil, HCO) for subcutaneous delivery. Solvent-melting technology was employed prepare IVM-SDs using HCO. The physicochemical properties the were evaluated by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), and Fourier transform infrared spectroscopy (FTIR). IVM from with HPLC vitro. Pharmacokinetics studied rabbits following single administration...
The tumor vasculature with unique characteristics offers an attractive target for anti-cancer therapy. Herein, we put forward a novel antitumor therapeutic mechanism based on the gadofullerene nanocrystals (GFNCs), agent have previously shown to efficiently disrupt by size-expansion assistance of radiofrequency (RF). However, vascular disrupting RF-assisted GFNCs treatment was not further studied. In present work, rapid blood flow shutdown has been observed perfusion imaging in vivo and...
The traditional photodynamic therapy (PDT) using a photosensitizer and oxygen under light generates reactive species (ROS) to kill tumor cells.
Despite the great efforts for tumor therapy in last decades, currently chemotherapy induced toxicity remains a formidable problem cancer patients, and it usually prohibits from successful completion due to severe side effects. In general, main effects of chemotherapeutic agents are as-produced reactive oxygen species (ROS) that not only harm cells but also damage patients' organs. Here we report application amino acid derivatives fullerene (AADF) which strongly scavenge excess ROS protect...
A proposed molecular mechanism of the anti-apoptosis effect GF-Ala through a mitochondria mediated pathway.
Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, closely related to progression. In this study, we investigated the biological function mechanism action Gankyrin glycolysis its association with NSCLC. Analyzed data from The Cancer Genome Atlas as well NSCLC specimens adjacent tissues demonstrated that expression was upregulated compared normal tissues. found significantly...
Tumor-associated antigens (TAAs) trigger a TAA-specific immune response, thus they are the crux of antitumor immunosurveillance. A major advance in tumor immunology last 20 years was marked by verification that CTL or B-cell epitopes rather than integral TAAs induce immunoreactivity. Previous studies on correlation between heparanase (Hpa) expression and clinical pathological features have generally used commercial antibodies against full-length Hpa protein functional epitopes, antigen...
It is important to get high-quality magnetic resonance images at high field (>3 T) for medical diagnoses.
Objective: This study aims to apply closed Non-interactive Literature-Based Knowledge Discovery into the field of traditional Chinese medicine (TCM) excavate invisible connection between non-interactive documents and probe possible hazard factors diagnosis treatment TCM on Diabetic Retinopathy, thus offer references for scientific research clinical scientists. Methods: Discovery, a kind unique informatics method proposed by DR. Swanson from U. S., consists two processes, namely, open...
GF-Ala afforded a significant protection against insulin resistance induced by oxidative stress in 3T3-L1 adipocytes. It could reverse the increase of JNK activation and decreases insulin-stimulated PI3K, Akt, p70S6K GLUT4 translocation.