A5100416822- Spectroscopy and Laser Applications
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Atmospheric and Environmental Gas Dynamics
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Atmospheric Ozone and Climate
- Mitochondrial Function and Pathology
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Sustainable Supply Chain Management
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related gene regulation
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and Biological Activities
Zhongnan Hospital of Wuhan University
2024-2025
Wuhan University
2024-2025
Zhuhai People's Hospital
2022-2024
Jinan University
2013-2024
Anhui Medical University
2020-2024
Dongguan People’s Hospital
2023-2024
Jining Medical University
2024
First Affiliated Hospital of Anhui Medical University
2022-2024
First Affiliated Hospital of Jinan University
2024
Shandong Academy of Agricultural Sciences
2022
Gastric cancer (GC) is the fifth most commonly diagnosed malignancy. Paclitaxel (PTX) an effective first-line chemotherapy drug in GC treatment, but resistance of PTX attenuates therapeutic effect. Circular RNA circ-PVT1 can exert oncogenic effect GC. But function involved still unknown. In present study, expression levels circ-PVT1, miR-124-3p and ZEB1 PTX-resistant tissues cells were detected by quantitative real-time polymerase chain reaction (RT-qPCR). was assessed...
Abstract Mitochondrial dysfunction is becoming one of the main pathology factors involved in etiology neurological disorders. Recently, mutations coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10 (CHCHD10) which encode two homologous proteins that belong to mitochondrial CHCH protein family, are linked Parkinson’s disease amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD), respectively. However, physiological pathological roles these twin have not been...
Abstract Endonuclease G (ENDOG), a nuclear-encoded mitochondrial intermembrane space protein, is well known to be translocated into the nucleus during apoptosis. Recent studies have shown that ENDOG might enter matrix regulate genome cleavage and replication. However, little about role of in cytosol. Our previous work showed cytoplasmic competitively binds with 14-3-3γ, which released TSC2 repress mTORC1 signaling induce autophagy. Here, we demonstrate could also release Rictor from 14-3-3γ...
Aggresomes are the product of misfolded protein aggregation, and presence aggresomes has been correlated with poor prognosis in cancer patients. However, exact role tumorigenesis progression remains largely unknown. Herein, multiomics screening reveal that OTUD1 plays an important retaining ovarian stem cell (OCSC) properties. Mechanistically, elevated levels lead to formation OTUD1-based cytoplasmic aggresomes, which is mediated by a short peptide located intrinsically disordered N-terminal...
Background/Aims: The ubiquitin-specific peptidase USP22 mediates various cellular and organismal processes, such as cell growth, apoptosis, tumor malignancy. However, the molecular mechanisms that regulate activity remain poorly understood. Here we identify STAT3 a new interactor. Methods:· We used western blotting RT-PCR to measure key protein, acetylated STAT3, mRNA levels in HEK293 colorectal cancer lines transfected with expression plasmids or specific siRNAs. Co-immunoprecipitation was...
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes mellitus. Ginsenoside Rg1 (Rg1) an important active ingredient extracted from Panax ginseng. This study aimed to investigate role and molecular mechanism DN model.The mesangial cell line HBZY-1 was induced by high glucose (HG; 30 mM D-glucose). HG-induced cells were treated with (2.5, 5, 10 µmol/L). Cell viability measured MTT assay. Apoptosis detected flow cytometry. Related proteins western blot....
Abstract Photoacoustic spectroscopy (PAS), as a nondestructive method, permits high sensitivity and selectivity in trace gas detection fields. Advances differential PAS configurations have dramatically suppressed the background noise triggered detectivity improvement. A detailed review on development of photoacoustic sensors is presented: using two identical cavity cells optical path types provides good performance for coherent suppression, mode excitation technique, which evaluates signal...
The incidence of primary liver cancer (PLC) has experienced a significant global increase, primarily attributed to the rise in hepatocellular carcinoma (HCC). Unfortunately, HCC is often diagnosed advanced stages, leaving patients with limited treatment options. Therefore, transformation therapy crucial approach for long-term survival and radical resection HCC. Conversion demonstrated promise When integrated FOLFOX regimen, hepatic artery infusion chemotherapy (HAIC) can significantly...
More and more countries employ the Carbon Cap Trade mechanism (CCT-mechanism) to stimulate manufacturer produce much eco-friendly products. In this paper, we study how CCT-mechanism affects competitive manufacturers’ product design pricing strategies. Assume that there are two manufacturers; give optimal closed form solutions of carbon emission reduction rates retail prices in Nash game model Stackelberg with CCT-mechanism, respectively. Additionally, also discuss impacts consumer...
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy. The aims of the present study were to screen critical miRNA and corresponding target genes that related development ESCC by weighted gene correlation network analysis (WGCNA) investigate functions experimental validation.Datasets mRNA expression data downloaded from GEO. R software was used for preprocessing differential analysis. differentially expressed protein-coding (DEGs) miRNAs (DEMs) selected (FDR <0.05 or...
Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2), a mammalian orthologue of drosophila flamingo, belongs to the cadherin subfamily. CELSR2 mainly function in neural development and cilium polarity. Recent studies showed that gene is related many human diseases, including coronary artery disease, idiopathic scoliosis, cancer. Genome-Wide Association Studies data SNP CELSR2-PSRC1-SORT1 loci has strong association with circulating lipid levels disease. However, underlying mechanism...
Baipuhuang Keli (BPH, constituted by Bai Tou Weng (Pulsatilla chinensis (Bunge) Regel), Pu Gong Ying (Taraxacum mongolicum Hand.-Mazz.), Huang Qin (Scutellaria baicalensis Georgi), Bo (Phellodendron amurense Rupr.)) is a Chinese herbal formula with clearing heat and cooling blood, removing toxin effects, which suit for the case of breast cancer.Here, we aim to explore effects BPH on triple-negative cancer (TNBC) its potential mechanisms.In this study, cell viability assay, colony formation...
Abstract C11orf54 is an ester hydrolase highly conserved across different species. has been identified as a biomarker protein of renal cancers, but its exact function remains poorly understood. Here we demonstrate that knockdown decreases cell proliferation and enhances cisplatin-induced DNA damage apoptosis. On the one hand, loss reduces Rad51 expression nuclear accumulation, which results in suppression homologous recombination repair. other HIF1A competitively interact with HSC70,...
A novel quantitative method using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry was developed for simultaneous determination of the important active constituents including shionone, luteolin, quercetin, kaempferol and ferulic acid in Aster tataricus from different habitats. The separation performed on a C18 column with acidified aqueous acetonitrile gradients. Quantification analytes achieved by use hybrid quadrupole spectrometer. Multiple...
Bupleurum chinense DC is a plant widely used in Chinese traditional medicine. Saikosaponins are the major bioactive constituents of B. DC. biosynthesis has been more intensively studied than any other metabolic processes or constituents. However, whole-genome sequencing and chromosome-level assembly for genus have not reported yet. Here, we report high-quality genome through integration PacBio long-read sequencing, Illumina short-read Hi-C sequencing. The was phased into haplotype 0 (621.27...
Lung cancer is the leading cause of cancer-associated mortality worldwide, and most lung cancers are classified as non-small cell (NSCLC). MiR-328 influence progression multiple tumors, but role miR-328-5p in NSCLC has not been elucidated. The aim this study was to illuminate oncogenic potential molecular mechanisms lysyl oxidase like 4 (LOXL4) NSCLC.Expression detected by real-time quantitative polymerase chain reaction (qRT-PCR) tumor non-tumor adjacent tissues. After Lentivirus-miR-328-5p...