A5103008812- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Kruppel-like factors research
- Urinary and Genital Oncology Studies
- Endometrial and Cervical Cancer Treatments
- Effects of Radiation Exposure
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Cytokine Signaling Pathways and Interactions
- Vitamin D Research Studies
- Cancer-related Molecular Pathways
- Toxin Mechanisms and Immunotoxins
- S100 Proteins and Annexins
- Reproductive tract infections research
- DNA Repair Mechanisms
- Pulmonary Hypertension Research and Treatments
- High Altitude and Hypoxia
Nanjing Medical University
2016-2025
Nanjing Maternity and Child Health Care Hospital
2015-2025
Jiangxi University of Traditional Chinese Medicine
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Shanghai University of Traditional Chinese Medicine
2025
Jiangsu Province Hospital
2023-2024
Kangda College of Nanjing Medical University
2019
University of Arizona
2016
The Ohio State University
1991
// Mingming Lv 1,* , Pengfei Xu Ying Wu Lei Huang 3 Wenqu Li Shanshan 1 Xiaowei 5 Xin Zeng Rong Shen Xuemei Jia Yongmei Yin Yun Gu 2 Hongyan Yuan 1,4 Hui Xie 1,3 and Ziyi Fu Nanjing Maternity Child Health Medical Institute, Affiliated Maternal Hospital, University, Nanjing, China Department of Pathology, First 4 Oncology Lombardi Comprehensive Cancer Center, Georgetown University Washington, D.C., USA Pharmacology, School Basic Sciences, * These authors have contributed equally to this work...
Abstract Long noncoding RNA (lncRNA) has been recognized as a regulator of gene expression, and the dysregulation lncRNAs is involved in progression many types cancer, including epithelial ovarian cancer (EOC). To explore potential roles EOC, we performed lncRNA mRNA microarray profiling malignant benign cyst healthy control tissues. In this study, 663 transcripts were found to be differentially expressed EOC compared with normal We also selected 18 altered confirm validity analysis using...
Abstract Background Long-non-coding RNA PVT1 (lncRNA PVT1) can be used as an oncogenic regulatory non-coding (ncRNA) for many cancers. However, its function and mechanism in breast cancer (BRCA) are still not clearly elucidated. Objective We attempt to explain the of PVT1’s role from different perspectives. Methods analyzed expression correlation with related clinical data The Cancer Genome Atlas (TCGA) database. overexpression knockdown lentivirus infect MDA-MB-231 cell line verification,...
Abstract Gynaecologic and breast cancers share some similarities at the molecular level. The aims of our study are to highlight differences about IDO1, an important immune‐related gene in female cancers. NGS data from TCGA cervical squamous cell carcinoma (CESC), ovarian serous cystadenocarcinoma (OV), uterine corpus endometrial (UCEC), carcinosarcoma (UCS) invasive (BRCA) were analysed identify features, clinically significant potential therapeutic targets IDO1. We found IDO1 was...
The study aimed to evaluate the effectiveness of using specific indicators, particularly apparent diffusion coefficient (ADC), alone or in combination differentiate endometrial cancer (EC) from atypical hyperplasia (AEH) and explore non-invasive biomarkers for molecular classification EC. A retrospective analysis was conducted on 300 EC 126 AEH cases who had undergone preoperative magnetic resonance imaging, complete blood count, coagulation profile testing, tumor assessment. Postoperative...
The incidence of and mortality due to atherosclerosis, a leading cause cardiovascular disease, is rising annually. Oleanolic acid (OA), an active component the traditional Chinese medicine Ligustrum lucidum, has been proven have significant anti-inflammatory lipid-lowering potential. fli1a::EGFP+ zebrafish fed with oxidized low-density lipoprotein (oxLDL) diet were used as Atherosclerosis model. model oxalic driven by superparamagnetic ferrite nanoparticles (OA@SPIONs). Isolation enrichment...
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy. The aims of the present study were to screen critical miRNA and corresponding target genes that related development ESCC by weighted gene correlation network analysis (WGCNA) investigate functions experimental validation.Datasets mRNA expression data downloaded from GEO. R software was used for preprocessing differential analysis. differentially expressed protein-coding (DEGs) miRNAs (DEMs) selected (FDR <0.05 or...
Abstract Background To rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC). Methods The RNA-sequence clinical information were from the TCGA GTEx databases. We operated Cox regression to determine signatures related overall survival (OS) recurrence-free (RFS) respectively. diagnostic effectiveness of prognostic further explored. Results identified nine ( VAMP7 , MTMR14 ATG4D KLHL24 TP73 NAMPT CD46 HGS ATG4C ) three risk SERPINA1 HSPB8 SUPT20H...
This study aimed to explore the expression and hypermethylation of EPB41L3 JAM3 in cervical squamous cell carcinoma (CSCC) investigate their clinical significance. mRNA was analyzed using a public database, protein detected immunohistochemistry. The methylation status CSCC tissues cytological specimens quantitative methylation-specific PCR (qMSP). were downregulated CSCC. positively 39.4% frequently expressed those with lower FIGO stage no lymph node metastasis. 18.9% tissues. 52.3% related...
Radiation-induced bystander effect (RIBE) can promote tumor metastasis contributing to the failure of radiotherapy for esophageal squamous cell carcinoma (ESCC). Aberrant expression DJ-1 has been identified in ESCC; however, relationship between and RIBE ESCC remains unknown.We detected serum supernatants by enzyme-linked immunosorbent assay (ELISA) evaluated phenotypic experiments vivo vitro. RNA-seq, mass spectrometry, western blot (WB), immunoprecipitation (IP), dual-luciferase reporter...
Background Ovarian serous carcinoma (OSC) is the most common ovarian epithelial malignancy. Despite new medical and surgical advances, overall 5-year survival for OSC remains poor. There an important need to determine diagnostic prognostic markers this disease. Eph receptors are largest known family of receptor tyrosines characterised in humans. These involved development progression various diseases including cancer. EphB6 contains kinase domains that altered several conserved amino acids...
Ovarian cancer is the most lethal gynecological tumor in women worldwide. FAM111B (family with sequence similarity 111 member B) an oncoprotein associated multiple cancers, but its biological functions ovarian remain elusive. In this study, was overexpressed tissues and cell lines. Functional studies vitro revealed that silencing of inhibited proliferation, invasion, migration, as well increased apoptosis. Furthermore, arrested cycle at G1/S phase. western blot assays demonstrated resulted...
Cervical cancer is the most common gynecological cancer, encompassing cervical squamous cell carcinoma, adenocarcinoma, and other epithelial tumors. There are many diagnostic methods to detect cancers but no precision screening tool for adenocarcinoma at present.The mucus from three normal cervices (Ctrl), endocervical (EA), in situ (AIS) was collected proteomic analysis. The proteins were screened using liquid chromatography-mass spectrometry analysis (LC-MS). biological function of...
As a mitochondrial membrane protein, globular C1q receptor (gC1qR) can mediate variety of biological responses. Our study aims to investigate the role gC1qR in paclitaxel-induced apoptosis human ovarian cancer cells and elucidate its potential molecular mechanism. The level was examined using real-time PCR western blot analyses. Human viability, migration, proliferation were detected water-soluble tetrazolium salt (WST-1) assay, transwell H-thymidine incorporation into DNA (H-TdR)...
Restricted accessAbstractFirst published online March 1, 2016Role of Endothelial Hypoxia-Inducible Factors in Hypoxia-Induced Pulmonary VasoconstricitonY Gu, H Tang, […], JG Garcia, JX Yuan, DR Fraidenburg, J Chen, and A Makino+4-4View all authors affiliationsVolume 64, Issue 4https://doi.org/10.1136/jim-2016-000120.132