A5100329919- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- interferon and immune responses
- Occupational exposure and asthma
- Nanoplatforms for cancer theranostics
- Reproductive System and Pregnancy
- IL-33, ST2, and ILC Pathways
- Advanced Nanomaterials in Catalysis
- Cytokine Signaling Pathways and Interactions
- Luminescence and Fluorescent Materials
- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- HIV-related health complications and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related gene regulation
- Toxoplasma gondii Research Studies
- Immune Cell Function and Interaction
- Fatty Acid Research and Health
- Neurological Disease Mechanisms and Treatments
- NF-κB Signaling Pathways
Shanghai Institute of Nutrition and Health
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Shanghai Institutes for Biological Sciences
2025
University of South China
2024
China Medical University
2012-2023
Army Medical University
2023
Southwest Hospital
2023
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
NLRP3 inflammasome activation plays an important role in diabetic cardiomyopathy (DCM), which may relate to excessive production of reactive oxygen species (ROS). Gypenosides (Gps), the major ingredients Gynostemma pentaphylla (Thunb.) Makino, have exerted properties anti-hyperglycaemia and anti-inflammation, but whether Gps improve myocardial damage mechanism remains unclear. Here, we found that high glucose (HG) induced by activating then promoting IL-1β IL-18 secretion H9C2 cells NRVMs....
Scope Premature ovarian insufficiency (POI) is a common female infertility problem, with its pathogenesis remains unknown. The NOD‐like receptor family pyrin domain‐containing 3 (NLRP3)‐mediated pyroptosis has been proposed as possible mechanism in POI. This study investigates the therapeutic effect of α‐ketoglutarate (AKG) on reserve function POI rats and further explores potential molecular mechanisms. Methods results are caused by administration cyclophosphamide (CTX) to determine whether...
The implementation of pyroptosis exhibits significant potential as a tactic to enhance tumor immune microenvironments. Previous applications inducers have encountered various limitations, such the development drug resistance, manifestation toxic side effects, and deficiency in targeting capabilities. As result, there is growing demand for therapeutic molecules that can overcome these obstacles. Therefore, objective this study develop multifunctional nanospheres addresses challenges by...
Dysfunction of the non-canonical NF-κB signaling pathway has been causally associated with numbers cancers and autoimmune diseases. However, specific inhibitors for this remain to be developed. Here we showed that structure-based cell-based screening yielded a potent small molecule targeting RelB inhibit pathway, while had no inhibitory effect on canonical pathway. Mechanistically, inhibitor directly interacted protein disrupted binding its target DNA, thus repressing transactivity genes....
Purpose: This study aimed to investigate the regulatory effects of methylene blue (MB) on diabetic retinopathy (DR) and explored molecular mechanisms MB as a retina protection agent. Methods: The thicknesses retinal layers permeability blood-retinal barrier (BRB) were measured by histology analysis, expression levels NLRP3, ASC, procaspase-1, caspase-1, IL-1β, IL-18 western blotting. Lentivirus-based knockdown NLRP3 gene was used confirm role inflammasome. Results: treatment attenuates DR...
Short-chain fatty acids are gut-bacteria-derived metabolites that execute important regulatory functions on adaptive immune responses, yet their influence inflammation driven by innate immunity remains understudied. Here, we show propionate treatment in drinking water or upon local application into the joint reduced experimental arthritis and lowered inflammatory tissue priming mediated synovial fibroblasts. On a cellular level, incubation of fibroblasts with physiological mixture...
Exposure to crystalline silica (CS) results in a persistent pulmonary inflammatory response, which abnormal tissue repair and excessive matrix deposition. Due vague pathogenesis, there is virtually no practical therapeutic approach. Here we showed the pharmacological effects of TUDCA on CS-induced inflammation fibrosis. It also helped faster recovery CS-impaired function. Mechanistically, suppressed interferon (IFN)-γ interleukin (IL)-17A productions by helper T (Th) cells. We demonstrated...
Objectives The purpose of this study was to prospectively investigate the value real-time ultrasound elastography for diagnosis liver fibrosis in patients with chronic hepatitis B and correlate elastographic findings histologic stages blood parameters. Methods Liver biopsies, testing, were performed 71 viral cirrhosis. ratio elastic strain tissue that muscle determined correlated laboratory examination results. Results There a highly negative correlation between stage (Spearman r = −0.702; P...
Abstract Background Antiretroviral therapy (ART) can reduce opportunistic infections and mortality rates among individuals infected with human immunodeficiency virus (HIV); however, some HIV-infected exhibit poor immune recovery after ART. Hence, we explored the association between metabolome profiles in following Methods An untargeted metabolomics approach was used to analyze plasma samples from 18 HIV-negative 20 individuals, including 10 immunological non-responders (INR, CD4 + T cell...
The dual ligand functionalization of UCNP and MOF assembly on multiple UCNPs to obtain nanohybrid UCMs.
Occupational exposure to crystalline silica (CS) results in a persistent pulmonary inflammatory response that eventually leads abnormal tissue repair, disability, and death. The inflammatory-immune responses occur the early stages of CS exposure, both innate adaptive immunity are involved. CD4+ T cells play pivotal role pathogenesis CS-induced disease, which has no proven curative therapy. Dihydrotanshinone I (DHI), natural product isolated from Salvia miltiorrhiza Bunge (Danshen),...
Silicosis is caused by exposure to crystalline silica (CS). We have previously shown that blocking 4-1BB signaling attenuated CS-induced inflammation and pulmonary fibrosis. However, the cells express 4-1BB, which plays a vital role in promoting fibrosis, are still unknown. In this study, we demonstrated expression of elevated alveolar macrophages (AMs) lungs CS-injured mice. CS also markedly enhanced macrophage-like, MH-S cells. these cells, activation with an agonist antibody led...
Background Tonsil hypertrophy has negative impact on children's health, but its pathogenesis remains obscure despite the fact that numerous bacteriological studies have been carried out. Understanding innate immune and inflammatory states of hypertrophic tonsils with different clinical manifestations is great significance for defining tonsil establishing treatment strategies. The present study was undertaken to examine characteristics immunity inflammation in children palatine...
Background: Intestinal tumors are the third most common malignant worldwide, accounting for approximately 10% of all new cancer cases worldwide. Cancer prevention is a promising way to limit intestinal tumor incidence rate; however, challenges remain. Qingchang Wenzhong decoction (QCWZD) can clinically treat mild moderate ulcerative colitis symptoms. Moreover, mechanism by which it prevents has not been clarified. In this study, we explored QCWZD occurrence tumors. Methods: To study...
Autosomal dominant non-syndromic hearing loss (ADNSHL) has a broad phenotypic spectrum which includes bilateral, symmetrical, and high-frequency sensorineural loss, that eventually progresses into at all frequencies. Several genetic variations have been identified as causal factors underlying deafness, autosomal 5 (DFNA5) gene-related loss. Here, we report novel mutation (c.991-1G > C) in DFNA5, co-segregated with late-onset ADNSHL Chinese family was via exome sequencing Sanger of DNA from...
Bone morphogenetic proteins (BMPs) secreted by a variety of cell types are known to play essential roles in differentiation and matrix formation the bone, cartilage, muscle, blood vessel, neuronal tissue. BMPs activate intracellular effectors via C-terminal phosphorylation Smad1, Smad5, Smad9, which relay signaling forming complex with Smad4 translocate nucleus for transcriptional activation. Smad6 inhibits BMP through diverse mechanisms operative at membrane, cytosolic, nuclear levels....
5-aminolevulinic acid photodynamic therapy (ALA-PDT) is highly effective in the treatment of condyloma acuminata (CA). Previous research has indicated that ALA-PDT could induce cell death by different mechanisms, including apoptosis and autophagy, but role pyroptosis remains uncertain. Thus, this study aimed to explore whether a potential mechanism killing human papillomavirus (HPV) infected cells. HPV-positive HeLa cells were exposed ALA-PDT, then viability assay, lactate dehydrogenase...