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Benjamin Wirth

ORCID: 0000-0001-7006-0410
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About
Contact & Profiles
A5020053026
Research Areas
  • Immune cells in cancer
  • Inflammasome and immune disorders
  • Pathogenesis and Treatment of Hiccups
  • Ubiquitin and proteasome pathways
  • Protein Degradation and Inhibitors
  • Autoimmune and Inflammatory Disorders Research
  • Urticaria and Related Conditions
  • Multiple Myeloma Research and Treatments

Universitätsklinikum Erlangen
 2021-2022

Friedrich-Alexander-Universität Erlangen-Nürnberg
 2021-2022

 The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
OPENALEX - Publications 
Jasna Friščić Martin Böttcher Christiane Reinwald Heiko Bruns Benjamin Wirth and 45 more Samantha-Josefine Popp Kellie Walker Jochen A. Ackermann Xi Chen Jason D. Turner Honglin Zhu Lisa Seyler Maximilien Euler Philipp Kirchner René Krüger Arif B. Ekici Triin Major Oliver Aust Daniela Weidner Anita Fischer Fabian T. Andes Željka Stanojević Vladimir Trajkovič Martin Herrmann Adelheid Korb‐Pap Isabel Wank Andreas Heß Johnathan Winter Viktor Wixler Jörg H. W. Distler G Steiner Hans P. Kiener Benjamin Frey Lasse Kling Karim Raza Silke Frey Arnd Kleyer Tobias Bäuerle Timothy R. Hughes Anika Grüneboom Ulrike Steffen Gerhard Krönke Adam P. Croft Andrew Filer Jörg Köhl Kerstin Klein Christopher D. Buckley Georg Schett Dimitrios Mougiakakos Markus Hoffmann

10.1016/j.immuni.2021.03.003 article EN publisher-specific-oa Immunity 2021-03-23
 Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition
OPENALEX - Publications 
Jasna Friščić Christiane Reinwald Martin Böttcher Miranda Houtman Maximilien Euler and 14 more Xi Chen Kellie Walker Philipp Kirchner Honglin Zhu Benjamin Wirth Daniela Weidner René Krüger Vladimir Trajkovič Arif B. Ekici Kerstin Klein Dimitrios Mougiakakos Caroline Ospelt Georg Schett Markus Hoffmann

Objective We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis flares. Pathogenic SFs is essentially mediated by epigenetic reprogramming. Bromodomain and extraterminal motif (BET) proteins translate changes into transcription. Here, we used a BET inhibitor (I‐BET151) to target inflammatory tissue reduce flare severity in murine experimental model. Methods BALB/c mice were treated intraperitoneal injection or local the paw with I‐BET151, which blocks interaction...

10.1002/art.42378 article EN cc-by-nc Arthritis & Rheumatology 2022-10-17
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