A5020703092- Autophagy in Disease and Therapy
- Multiple Sclerosis Research Studies
- Aortic aneurysm repair treatments
- Natural Antidiabetic Agents Studies
- Aortic Disease and Treatment Approaches
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Pharmacovigilance and Adverse Drug Reactions
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Connective tissue disorders research
- Regulation of Appetite and Obesity
- PI3K/AKT/mTOR signaling in cancer
- Nosocomial Infections in ICU
- Anesthesia and Neurotoxicity Research
- Liquid Crystal Research Advancements
- Pharmacology and Obesity Treatment
- RNA regulation and disease
- Magnetic Properties and Synthesis of Ferrites
- Pigment Synthesis and Properties
University of Belgrade
2007-2024
Institute of Biochemistry
2018
Institute of Pharmacology
2004-2011
University of Prishtina
2011
Abstract Arylpiperazine‐based dopaminergic/serotonergic ligands exert neuroprotective activity. We examined the effect of arylpiperazine D 2 /5‐ HT 1A ligands, N‐{4‐[2‐(4‐phenyl‐piperazin‐1‐yl)‐ethyl}‐phenyl]‐picolinamide ( 6a ) and N‐{3‐[2‐(4‐phenyl‐piperazin‐1‐yl)‐ethyl]‐phenyl}‐picolinamide 6b ), in experimental autoimmune encephalomyelitis EAE a model neuroinflammation. Both compounds (10 mg/kg i.p.) reduced clinical signs spinal cord homogenate‐immunized Dark Agouti rats. Compound was...
J. Neurochem. (2011) 118 , 205–214. Abstract Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis. Dark Agouti rats immunized with spinal cord homogenate (SCH) and carbonyl iron (CI), as an adjuvant, develop severe hyperacute form EAE. They succumb to EAE earlier have higher clinical scores lethality rate in comparison counterparts SCH + complete Freund’s adjuvant. There no difference the number cells or histological presentation CNS infiltrates two adjuvants....
The protective activity of dry olive leaf extract (DOLE) in carbon tetrachloride (CCl4)-induced liver damage and possible mechanisms involved this protection were investigated rats. Acute CCl4 intoxication resulted a massive hepatic necrosis, increased serum transaminases, perturbation oxidative stress parameters tissue [malondyaldehide, glutathione (GSH), catalase]. did not affect the expression caspase-3 cytochrome c as markers apoptosis; however, AMP-activated protein kinase (AMPK)...
We examined the status and role of autophagy, a process lysosomal recycling cellular material, in clear cell renal carcinoma (ccRCC). Paired samples tumor adjacent non-malignant tissue were collected from 20 patients with ccRCC after radical nephrectomy. The mRNA levels apoptosis (BAD, BAX, BCL2, BCLXL, BIM) autophagy (ATG4, BECN1, GABARAP, p62, UVRAG) regulators measured by RT-qPCR. protein autophagosome-associated LC3-II, receptor apoptotic marker PARP, as well phosphorylation initiator...
Abstract Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, while it safe most healthy postmenopausal women, there are still existing concerns regarding an increased risk for breast endometrial cancer as well a cardiovascular thromboembolic disease. Therefore, certain natural compounds with positive effects may be considered possible...
Endoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins ER capacity to fold disrupted, nonfunctional, unfolded, or misfolded accumulate lumen, leading endoplasmic stress (ER stress). One of ways uses overcome unfolded response (UPR) activation. UPR initiated by activation three transmembrane proteins. These are IRE-1a (inositol requiring enzyme-1a), PERK (protein kinase RNA-like kinase) ATF6...
It is known that physical activity undoubtedly exhibits positive effects, decreasing the incidence of many chronic diseases. But, at present, consider a pre-analytical factor/error related to sampling process. Namely, different types as well its intensity may influence broad array laboratory variables. The amount extracellular release and clearance from blood most these biomarkers markedly influenced by biological characteristics molecule(s), level training, type, duration exercise, time...
<h3>Background</h3> Osteoporosis is the most common metabolic bone disease. Postmenopausal loss of estrogen a major risk factor. <h3>Objectives</h3> To assess if total ethanolic extract <i>Sideritis scardica</i> could prevent osteoporosis in ovariectomized female rats. <h3>Methods</h3> Female Wistar rats were divided three groups: I-sham operated (control), II-ovariectomized-OV and III-ovariectomized, treated orally with <i>S.scardica</i> (300 mg/kg) during 20 weeks-OVT. In 18th experimental...
Summary: Background: Main objective of this study was to evaluate the influence statins and/or acetylsalicylic acid on biochemical characteristics abdominal aortic aneurysm (AAA) wall and intraluminal thrombus (ILT). Patients methods: Fifty patients with asymptomatic infrarenal AAA were analyzed using magnetic resonance imaging T1w sequence. Relative ILT signal intensity (SI) determined as a ratio between psoas muscle SI. Samples containing full thickness harvested from anterior surface at...