A5084932079- Probiotics and Fermented Foods
- Autophagy in Disease and Therapy
- Microbial Metabolites in Food Biotechnology
- Gut microbiota and health
- Stress Responses and Cortisol
- Multiple Sclerosis Research Studies
- Posttraumatic Stress Disorder Research
- Anesthesia and Neurotoxicity Research
- Calcium signaling and nucleotide metabolism
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- Neuroendocrine regulation and behavior
- Phytochemistry and Bioactive Compounds
- Retinoids in leukemia and cellular processes
- Medicinal plant effects and applications
- Natural product bioactivities and synthesis
- Immune Response and Inflammation
- Protein purification and stability
- Parkinson's Disease Mechanisms and Treatments
- Forensic Toxicology and Drug Analysis
- Antimicrobial Peptides and Activities
- Spectroscopy and Quantum Chemical Studies
- Meat and Animal Product Quality
- Advanced Drug Delivery Systems
- Phytoestrogen effects and research
University of Belgrade
2014-2024
University of Novi Sad
2018
Zemun Hospital
2017
Galena Biopharma (United States)
2015
We investigated the role of autophagy, a controlled cellular self-digestion process, in regulating survival neurons exposed to atypical antipsychotic olanzapine. Olanzapine induced autophagy human SH-SY5Y neuronal cell line, as confirmed by increase autophagic flux and presence vesicles, fusion autophagosomes with lysosomes, expression autophagy-related (ATG) genes ATG4B, ATG5, ATG7. The production reactive oxygen species, but not modulation main repressor MTOR or its upstream regulators...
In this study, we checked lactobacilli strains of human origin for their potential as probiotic. Samples were collected from oral mucosa 16 healthy individuals, out which twenty isolates obtained and two them selected identified Lactobacillus plantarum (G1) L. casei (G3). Both exhibited antagonistic action towards pathogenic microorganisms such Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella abony, Clostridium sporogenes, but not on the growth Candida albicans....
Abstract Arylpiperazine‐based dopaminergic/serotonergic ligands exert neuroprotective activity. We examined the effect of arylpiperazine D 2 /5‐ HT 1A ligands, N‐{4‐[2‐(4‐phenyl‐piperazin‐1‐yl)‐ethyl}‐phenyl]‐picolinamide ( 6a ) and N‐{3‐[2‐(4‐phenyl‐piperazin‐1‐yl)‐ethyl]‐phenyl}‐picolinamide 6b ), in experimental autoimmune encephalomyelitis EAE a model neuroinflammation. Both compounds (10 mg/kg i.p.) reduced clinical signs spinal cord homogenate‐immunized Dark Agouti rats. Compound was...
The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and helveticus 52 on glucose (blood level tolerance), lipids (cholesterol triglycerides), transaminases (AST ALT), ALP, urea, creatinine, along with body weight, food intake, liquid consumption, gross pathology in a mouse model metabolic syndrome. Male C57BL/6J mice were fed high-fat high-sucrose diet treated by oral gavage probiotic mixture three different concentrations (107, 108, 109 CFU/mL) once daily for...
Diabetic neuropathy is one of the most deleterious complications diabetes mellitus in humans. High fat diet (HFD)‐fed C57BL/6 J mice are a widely used animal model for type 2 and metabolic syndrome. We investigated effects metformin simvastatin on ultrastructural characteristics sciatic nerve fibers these mice. Metformin treatment increased number structural defects myelin sheet surrounding already affected nerves HFD fed mice, reduced numbers to levels seen control These results warrant...
Abstract Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, while it safe most healthy postmenopausal women, there are still existing concerns regarding an increased risk for breast endometrial cancer as well a cardiovascular thromboembolic disease. Therefore, certain natural compounds with positive effects may be considered possible...
The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher selectivity. Research been done on potential novel O , ′‐diethylethylenediamine‐ N ′‐di‐3‐propanoate ( L ) ligand as a radionuclide vehicle targeting. Under alkaline conditions, hydrolyses produces half ester L' diacid L'' ), characteristic donor atom array . Ligand was successfully labelled 99m Tc at pH = 9 by coordination octahedral fac ‐[...
Objective: The suitability of the rabbit as an animal model for primary screening and selection pilot scale batches during early stages formulation development was studied.
Melanoma, an aggressive skin tumor with high metastatic potential, is associated mortality and increasing morbidity. Multiple available chemotherapeutic immunotherapeutic modalities failed to improve survival in advanced disease, the search for new agents ongoing. The aim of this study was investigate antimelanoma effects O , -diethyl-( S )-ethylenediamine- N ′di-2-(3-cyclohexyl) propanoate dihydrochloride (EE), a previously synthesized characterized organic compound. Mouse melanoma B16 cell...
Type 2 diabetes is a major health burden to the society. Macrophages and liver inflammation emerged as important factors in its development. We investigated ultrastructural changes liver, with special emphasis on macrophages high fat diet (HFD) fed C57BL/6 J mice treated metformin or simvastatin, two drugs that are used frequently diabetes. Both simvastatin reduced damage HFD animals, manifested prevention of nonalcoholic steatohepatitis development activation number well percentage these...
Abstract This study was conducted to explore the effects of specific psychosocial paradigm on predator animal posttraumatic stress model and test hypothesis that psychosocially stressed rats would exibit abnormal levels cortisol a larger suppression after application dexamethasone. Animals were divided in two groups: experimental control groups. The group exposed types stressors: acute immobilization stress, combined daily social with Blood sampling performed at three different times. We...
Aim: To further examine the neurobiological mechanisms and their outcomes responsible for PTSD sequelae induced by laboratory animal model to explore effects of chronic psychosocial paradigm. We tested hypothesis that our would display abnormalities in glucocorticoid levels are manifest people with psychosocially stressed rats exhibit a significantly greater suppression corticosterone than control following administration dexamethasone.Methods: Animals were divided into two groups. The...
<h3>Background</h3> Osteoporosis is the most common metabolic bone disease. Postmenopausal loss of estrogen a major risk factor. <h3>Objectives</h3> To assess if total ethanolic extract <i>Sideritis scardica</i> could prevent osteoporosis in ovariectomized female rats. <h3>Methods</h3> Female Wistar rats were divided three groups: I-sham operated (control), II-ovariectomized-OV and III-ovariectomized, treated orally with <i>S.scardica</i> (300 mg/kg) during 20 weeks-OVT. In 18th experimental...
Aim: To further examine the neurobiological mechanisms and their outcomes responsible for PTSD sequelae induced by laboratory animal model to explore effects of chronic psychosocial paradigm. We tested hypothesis that our would display abnormalities in glucocorticoid levels are manifest people with psychosocially stressed rats exhibit a significantly greater suppression corticosterone than control following administration dexamethasone.Methods: Animals were divided into two groups. The...
The present study was dedicated to determining probiotic potential of a human isolate G-4, originated from meconium. identified using morphological, physiological and biochemical assays molecular method based on 16S rRNA gene sequencing. In order evaluate its properties in vitro tests were performed: the survival simulated gastrointestinal conditions, adhesion hexadecane, antimicrobial activity. Safety aspects examined by testing toxicity, tolerance bacterial translocation vivo, as well...