A5047789081- Systemic Lupus Erythematosus Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Phytochemistry and Bioactive Compounds
- Drug-Induced Adverse Reactions
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- Eosinophilic Disorders and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Erythrocyte Function and Pathophysiology
- Asthma and respiratory diseases
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Immune cells in cancer
- Lichen and fungal ecology
- Agricultural economics and policies
- Livestock Management and Performance Improvement
- Sepsis Diagnosis and Treatment
- Inflammation biomarkers and pathways
University of Belgrade
2009-2023
Institute of Rheumatology
2009-2018
Center for Rheumatology
2018
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2016
Universitätsklinikum Erlangen
2013
Sideritis scardica Griseb. (ironwort, mountain tea), an endemic plant of the Balkan Peninsula, has been used in traditional medicine treatment gastrointestinal complaints, inflammation, and rheumatic disorders. This study aimed to evaluate its gastroprotective anti-inflammatory activities. Besides, continuously increasing interest assessing role active constituents preventing risk cancer was a reason make detailed examination investigated ethanol, diethyl ether, ethyl acetate, n-butanol...
There is a worldwide ongoing investigation for novel natural constituents with cytotoxic and antioxidant properties. The aim of this study was to investigate chemical profile stated biological activities the supercritical CO2 extract (SCE) old man’s beard compared extracts obtained using conventional techniques (Soxhlet macerate). most abundant compound identified usnic acid, which content inversely proportional polarity solvent used highest in SCE, sample revealing activity tested tumor...
Background: Decreased activity of serum desoxyribonuclease I (DNase I) in systemic lupus erythematosus (SLE) has been reported, but its role as a biomarker SLE is still unelucidated.
Abstract Hyperuricemia is strongly linked to cardiovascular complications including atherosclerosis and thrombosis. In individuals with hyperuricemia, needle-shaped monosodium urate crystals (nsMSU) frequently form within joints or urine, giving rise gouty arthritis renal calculi, respectively. These nsMSU are potent instigators of neutrophil extracellular trap (NET) formation. Little known on the mechanism(s) that prevent formation hyperuricemic blood, which would potentially cause...
The relationship between Systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection has been suggested for decades, but the underlying mechanism of EBV influence on SLE development remains to be elucidated.
<i>Sideritis scardica</i> (mountain tea) is an endemic plant on the Balkan Peninsula traditionally used for treating different conditions, mainly of inflammatory nature. This study was aimed to examine cytotoxic activity <i>S. extracts against rat glioma C6 line and astrocytes in primary culture. The obtained data revealed that diethyl ether (extract 2) ethyl acetate 3) exerted a effect cells. Diethyl extract induced increase reactive oxygen species production, leading apoptotic autophagic...
Although Epstein-Barr virus (EBV) reactivation has long been associated with the pathogenesis of systemic lupus erythematosus (SLE), many aspects this relationship remain unclear. Our objective was to investigate association between EBV and achievement SLE remission low disease activity state (LLDAS) over a six-month period. Clinical, laboratory, virological tests (anti-EBV antibodies DNA) were performed among 51 patients active form on two occasions six months apart. LLDAS assessed at end...
We present a 43-year-old woman with relapsing–remitting multiple sclerosis (MS) who developed lupus syndrome after 32 months of IFN-β-1a therapy. She presented malaise, myalgia, arthralgia and fever. Laboratory tests showed high erythrocyte sedimentation rate, anaemia lymphopenia. Antibodies to double stranded DNA (dsDNA) IgG, IgM IgA classes were detected on Critidia luciliae. Additionally, levels anti-nucleosomal antibodies, low anti-histone anti-Ro/SSA antibodies also found. Diagnosis...
Healthy cells exhibit an asymmetric plasma membrane with phosphatidylserine (PS) located on the cytoplasmic leaflet of bilayer. Annexin A5-FITC, a PS binding protein, is commonly used to evaluate apoptosis in flow cytometry. exposed by apoptotic serves as major 'eat-me' signal for phagocytes. Although exposition has been observed after alternative stimuli, no clearance viable, exposing detected. Thus, besides exposure, membranes viable and might specific characteristics. Here, we show that...
Abstract Objective: Cross-cultural validation of the Serbian version Modified Falls Efficacy Scale (MFES). Methods: This cross-sectional study involved 257 women aged 65 years and above who were referred for dual-energy x-ray absorptiometry examination at Railway Healthcare Institute in Belgrade, Serbia, between January April 2016. Data collection comprised a sociodemographic questionnaire Geriatric Depression Scale-Short Form (GDS-SF) questionnaire, data related to fractures, level physical...
<b><i>Objective:</i></b> The aim of this paper is to report<b> </b>the first case drug-induced eosinophilic myocarditis (EM) in a patient with hereditary periodic fever syndrome (PFS). <b><i>Case:</i></b> A 28-year-old man hyper-IgD syndrome, one the PFS, developed sulfasalazine-induced systemic hypersensitivity reaction complicated by EM. Thirteen days after sulfasalazine introduction, which had been given for arthritis, fever,...
We present a patient who developed carbamazepine (CBZ)-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated high serum procalcitonin (PCT). The presentation (high fever, hepatosplenomegaly, leukocytosis), PCT CRP initially suggested sepsis, he was treated antibiotics, while CBZ continued. rash hepatitis worsened. After withdrawal of CBZ, corticosteroid therapy administered the recovered normalization PCT. This case demonstrates that may be increased in...
Systemic lupus erythematosus (SLE) is characterized by an imbalance between proinflammatory and anti-inflammatory mediators. Single-nucleotide polymorphisms (SNPs) in genes coding IL10RA, IL10RB, IL22RA could affect their expression or function disrupt immune homeostasis. We aimed to analyze the associations of polymorphisms/haplotypes with patients' susceptibility clinical manifestations SLE. Our study included 103 SLE patients 99 healthy controls. The genotypes selected within IL10RA...
Background. Despite successful primary percutaneous coronary intervention (PCI) after ST-segment elevation myocardial infarction (STEMI), some patients develop left ventricular systolic dysfunction (LVSD) and acute heart failure (HF). Identifying with an increased risk of developing LVSD by means biomarkers may help select requiring more aggressive therapy.Objectives. The aim this study was to evaluate the relationship between levels oxidative stress markers development HF early...
Abstract Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, while it safe most healthy postmenopausal women, there are still existing concerns regarding an increased risk for breast endometrial cancer as well a cardiovascular thromboembolic disease. Therefore, certain natural compounds with positive effects may be considered possible...
Epstein–Barr virus (EBV) infection has been shown as a potential risk factor for the development of rheumatoid arthritis (RA). This prospective research aimed to investigate whether EBV markers changed during six-month follow-up period in 133 RA patients (80 newly diagnosed on methotrexate (MTX)—RA-A, and 53 biologic therapy—RA-B) it was related disease outcome. Reduction activity inflammation obtained. A significant decline seroprevalence titer anti-VCA-IgM (p = 0.022 p 0.026)...
Causes for cow culling in a tie stall system were investigated on sample of 3060 cows culled 2011, seven large dairy farms the Belgrade region. The total level was 34.58% average number cows. decreased with lactation order (from 981 first to 294 sixth and later lactations). most dominant cause diseases legs hooves (28.4%), as expected, having mind system. If selection (low production) is abstracted reason culling, what stands out by importance are metabolic (15.7%) problems reproduction...
<h3>Background and Objectives</h3> In autoimmune conditions, like rheumatoid arthritis (RA), the own immune system attacks body causes inflammation. One of consequences inflammation during diseases is a changed glycosylation profile IgG antibodies. RA not only characterised by an altered N-glycan structure bound to Fc portion molecules but also circulating factors (RF) that recognizes as antigen. The aim our work was investigate complexes in blood patients with seropositive seronegative RA....
<h3>Background:</h3> Sjogren's syndrome is a relatively common autoimmune disease, especially in its early stages, and can have very nonspecific symptoms. Additionally, large number of patients positive rheumatoid factor (RF), which often misdirect the diagnosis towards arthritis. In RF-positive without anti-Ro antibodies, biopsy minor salivary gland necessary for disease diagnosis, unacceptable significant patients. For this reason, new diagnostic markers that could differentiate from...
Sideritis scardica Griseb., Lamiaceae (mountain tea), an endemic plant of Balcan peninsula, traditionally has been known for its anti-inflammatory and gastroprotective properties [1]. The dried aerial parts the mountain tea were extracted using ethanol, diethyl ether, ethyl acetate, n-butanol. total phenolics content was determined by Folin-Ciocalteu method. extracts tested their antioxidant activity measuring reduction DPPH absorption to indicate capacity scavenge free radicals. HPLC method...
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe, potentially life-threatening idiosyncratic drug reaction.It usually caused by antiepileptics, antibiotics or non-steroidal antiinflammatory drugs, after latency period of three weeks to months.Typical clinical features include mucocutaneous rash, fever, lymphadenopathy internal organ involvement.We report patient systemic sclerosis, rheumatoid arthritis osteoporosis who developed possible DRESS lamotrigine,...