A5005603726- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Pathology Studies
- Nanoparticle-Based Drug Delivery
- Medical Imaging Techniques and Applications
- Orthopaedic implants and arthroplasty
- Lymphoma Diagnosis and Treatment
- Characterization and Applications of Magnetic Nanoparticles
- Radiation Therapy and Dosimetry
- Radiation Effects and Dosimetry
- Radioactive Decay and Measurement Techniques
- Bone health and treatments
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- X-ray Diffraction in Crystallography
- Radioactive element chemistry and processing
- Ultrasound and Hyperthermia Applications
- Plant Genetic and Mutation Studies
- Monoclonal and Polyclonal Antibodies Research
- Nuts composition and effects
- Metal complexes synthesis and properties
- Protein Interaction Studies and Fluorescence Analysis
- Probiotics and Fermented Foods
- Gut microbiota and health
- Lung Cancer Treatments and Mutations
- Protein purification and stability
University of Belgrade
2015-2024
Institute of Economic Sciences
2004-2023
Vinča Institute of Nuclear Sciences
2005-2023
A. N. Nesmeyanov Institute of Organoelement Compounds
2023
Instituto Murciano de Investigación Biosanitaria
2023
Forschungs- und Beratungsstelle Arbeitswelt
2023
Japan Radioisotope Association
2017
Ministry of Interior of the Republic of Serbia
2017
Oncology Institute of Vojvodina
2003
Vienna Institute for Nature Conservation & Analyses
1999-2002
Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe3O4-Naked (80 ± 5 nm) and polyethylene glycol 600 diacid functionalized Fe3O4 (Fe3O4-PEG600) MNPs (46 0.6 nm). They characterized based on the external morphology, size distribution, colloidal properties. The obtained specific power absorption value for Fe3O4-PEG600 was 200 W/g, indicated potential hyperthermia cancer treatments. labeling yield, vitro stability...
The present study describes for the first time a procedure radiolabeling of fullerene (C60) nanocrystals (nanoC60) with Na 125I, as well biodistribution radiolabeled nanoC60 (125I–nanoC60). solvent exchange method tetrahydrofuran was used to make colloidal water suspensions particles. addition 125I during dissolution C60 gave higher radiochemical yield particles in comparison second option, which added after dissolved. Using photon correlation spectroscopy and transmission electron...
Radiolabeled albumin microspheres with encapsulated citric acid-coated magnetite nanoparticles were developed as a targeting approach to localize both radioactivity and magnetic energy at the tumor site. We present in vitro vivo studies of yttrium-90 (90Y)-labeled human serum (HSAMMS) multifunctional agent for possible applications bimodal radionuclide-hyperthermia cancer therapy. The HSAMMS produced using modified emulsification-heat stabilization technique contained 11 nm coated acid,...
Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated nontoxic to CT-26 mouse colon cells up 1.0 mg ml-1in vitro. In oscillating magnetic field, citrate-coated (CA/SPIONs) displayed highest rate (SAR ∼ 253 W g-1)...
The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and helveticus 52 on glucose (blood level tolerance), lipids (cholesterol triglycerides), transaminases (AST ALT), ALP, urea, creatinine, along with body weight, food intake, liquid consumption, gross pathology in a mouse model metabolic syndrome. Male C57BL/6J mice were fed high-fat high-sucrose diet treated by oral gavage probiotic mixture three different concentrations (107, 108, 109 CFU/mL) once daily for...
Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity energy at a tumor site. The coating of MNPs phosphates made them biocompatible, increased their colloidal stability allowed binding the radionuclide 90Y available functional groups on surface MNPs. IDP IHP have not hitherto been used for results this study functionalized...
As an alternative to classical brachytherapy, intratumoral injection of radionuclide-labeled nanoparticles (nanobrachytherapy, NBT) has been investigated as a superior delivery method over intravenous route for radionuclide therapy solid tumors. We created superparamagnetic iron oxide (SPIONs) coated with meso-1,2-dimercaptosuccinic acid (DMSA) and radiolabeled Lutetium-177 (177Lu), generating 177Lu-DMSA@SPIONs potential antitumor agent nanobrachytherapy. Efficient radiolabeling DMSA@SPIONS...
To investigate the influence of certain cytotoxic drugs on organ uptake following (99m)Tc-radiopharmaceuticals: (99m)Tc-2,3-dicarboxypropane-1,1-diphosphonic acid ((99m)Tc-DPD), (99m)Tc-meso-2,3-dimercaptosuccinic ((99m)Tc-DMSA), (99m)Tc-tin colloid and (99m)Tc-macroaggregated albumin ((99m)Tc-MAA). Methotrexate sodium cyclophosphamide were used as models to evaluate these effects.Two groups healthy male Wistar rats treated separately by oral application for 7 days. On eighth day, each...
Summary Colloidal particle size is an important characteristic to consider when choosing a radiopharmaceutical for diagnosis and therapeutic purposes in nuclear medicine. Photon correlation spectroscopy (PCS) transmission electron microscopy (TEM) were used determine the particle‐size distribution of 90 Y‐ 99m Tc‐labelled antimony trisulfide (Sb 2 S 3 ) tin colloids (Sn‐colloid). Y‐Sb Tc‐Sb found have diameter 28.92 ± 0.14 35.61 0.11 nm, respectively, by PCS. By TEM, particles measured be...
Two novel diamine dioxime ligands, 4,7‐diaza‐3,8‐diethyldecane‐2,9‐dione bis oxime (3) and 4,9‐diaza‐3,10‐diethyldodecane‐2,11‐dione (5), were synthesized in order to develop new brain perfusion imaging agents, based on 99m Tc(V)‐complexes. The synthesis involved condensation of 2‐hydroxyimino‐3‐pentanone with appropriate protic solvent which afforded the imine adducts. Subsequent reduction functional groups yielded a diastereoisomeric mixture 3 5. UV–visible, IR, 1 H NMR, 13 C NMR elemental...
The extensive development of radiopharmaceuticals towards early tumour detection and treatment has increased the demand for new ligands with higher selectivity. Research been done on potential novel O , ′‐diethylethylenediamine‐ N ′‐di‐3‐propanoate ( L ) ligand as a radionuclide vehicle targeting. Under alkaline conditions, hydrolyses produces half ester L' diacid L'' ), characteristic donor atom array . Ligand was successfully labelled 99m Tc at pH = 9 by coordination octahedral fac ‐[...