A5047349380- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Medical Imaging and Pathology Studies
- Radiation Therapy and Dosimetry
- Characterization and Applications of Magnetic Nanoparticles
- Radiopharmaceutical Chemistry and Applications
- Ultrasound and Hyperthermia Applications
- 3D Printing in Biomedical Research
- bioluminescence and chemiluminescence research
- Advanced biosensing and bioanalysis techniques
- Iron oxide chemistry and applications
- Mitochondrial Function and Pathology
- Transgenic Plants and Applications
- Erythrocyte Function and Pathophysiology
- Advanced Sensor and Energy Harvesting Materials
- Chemical Reactions and Isotopes
- Energy Harvesting in Wireless Networks
- Radiomics and Machine Learning in Medical Imaging
- Toxin Mechanisms and Immunotoxins
- Plant tissue culture and regeneration
- Innovative Energy Harvesting Technologies
- Advanced MRI Techniques and Applications
National and Kapodistrian University of Athens
2020-2024
National Centre of Scientific Research "Demokritos"
2017-2022
Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety
2017-2022
Institute of Nuclear and Particle Physics
2020
It has been proven and confirmed in numerous repeated tests, that the use of a combination several therapeutic methods gives much better treatment results than case separate therapies. Particularly promising is ionizing radiation magnetic hyperthermia one drug. To achieve this objective, magnetite nanoparticles have modified their core with α emitter 225Ac, an amount affecting only slightly properties. By 3-phosphonopropionic acid (CEPA) linker were conjugated covalently trastuzumab...
The aim of this study was to develop a dual-modality PET/MR imaging probe by radiolabeling iron oxide magnetic nanoparticles (IONPs), surface functionalized with water soluble stabilizer 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD), the positron emitter Gallium-68. Magnetite (Fe 3 O 4 MNPs) were synthesized via coprecipitation method and stabilized DPD. Fe -DPD MNPs characterized based on their structure, morphology, size, charge, properties. In vitro cytotoxicity studies showed reduced...
Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated nontoxic to CT-26 mouse colon cells up 1.0 mg ml-1in vitro. In oscillating magnetic field, citrate-coated (CA/SPIONs) displayed highest rate (SAR ∼ 253 W g-1)...
In vitro cell culture monitoring can be used as an indicator of cellular oxidative stress for the assessment different chemotherapy agents.A cell-based bioelectric biosensor was to detect alterations in superoxide levels medium HeLa cervical cancer cells after treatment with chemotherapeutic agent 5-fluorouracil (5-FU). The cytotoxic effects on were assessed by MTT proliferation assay, whereas damage and induction apoptosis measured fluorometrically mitochondria-targeted MitoSOX™ Red...
The combination of two imaging modalities in a single agent has received increasing attention during the last few years, since its synergistic action guarantees both accurate and timely diagnosis. For this reason, dual-modality contrast agents (DMCAs), such as radiolabeled iron oxide (namely Fe3O4) nanoparticles, constitute powerful tool diagnostic applications. In respect, here we focus on synthesis potential photon emission computed tomography/magnetic resonance (SPECT/MRI) DMCA, which...
The radiolabeled iron oxide nanoparticles constitute an attractive choice to be used as dual-modality contrast agents (DMCAs) in nuclear medical diagnosis, due their ability combine the benefits of two imaging modalities, for instance single photon emission computed tomography (SPECT) with magnetic resonance (MRI). Before use any DMCA, investigation its plasma extra- and on/intra cellular distribution peripheral human blood is paramount importance. Here, we focus on vitro 99mTc-DPD-Fe3O4...
The inevitable feedback between the environmental and energy crisis within next decades can probably trigger and/or promote a global imbalance in both financial public health terms. To handle this difficult situation, last decades, many different classes of materials have been recruited to assist management, production, storage so-called clean energy. Probably, ferromagnets, superconductors ferroelectric/piezoelectric stand at frontline applications that relate For instance, ferromagnets are...
Radiolabeled magnetic nanoparticles are promising candidates as dual-modality-contrast-agents (DMCA) for diagnostic applications. The immunocompatibility of a new DMCA is prerequisite subsequent in vivo Here, DMCA, namely Fe