It has been proven and confirmed in numerous repeated tests, that the use of a combination several therapeutic methods gives much better treatment results than case separate therapies. Particularly promising is ionizing radiation magnetic hyperthermia one drug. To achieve this objective, magnetite nanoparticles have modified their core with α emitter 225Ac, an amount affecting only slightly properties. By 3-phosphonopropionic acid (CEPA) linker were conjugated covalently trastuzumab...

Industrialization and the growing consumption of medicines leads to global aquatic contamination. One antibiotics widely used against bacterial infections in both human veterinary medicine is tetracycline. Despite its positive antibiotic action, tetracycline resistant degradation, therefore it accumulates environment, including creating great health hazards, possibly stimulating resistance pathogenic organisms. In this research, aqueous suspensions semiconductor nanoparticles CdS were for...

Hybrid materials consisting of a monoolein lipidic cubic phase (LCP) incorporating two types magnetic nanoparticles (NP) were designed as addressable drug delivery systems. The materials, prepared in the form gel, subsequently used macroscopic layer modifying an electrode and, after dispersion to nanoscale, magnetocubosomes. These LCPs characterized by small-angle X-ray scattering (SAXS), cross-polarized microscopy, measurements, and diagrams. dopants hydrophobic NPoleic hydrophilic...

The challenges associated with the uncontrolled presence of antibiotics such as tetracycline in environment have necessitated their removal through different techniques. Tetracycline is hard to degrade living organisms and can even be converted more toxic substances. In view this, we synthesized iron oxide nanoparticles good magnetization (70 emu g−1) 15 nm particle size for adsorption photocatalytic degradation tetracycline. Characterization carried out on oxides revealed a bandgap 1.83 eV...

Abstract A novel degradable microgel based on poly( N -isopropylacrylamide) (pNIPA) cross-linked with , ’-bisacryloylcystine (BISS) and containing superparamagnetic iron oxide nanoparticles (SPION@CA) was synthesized by semi-batch precipitation polymerization examined as a potential hyperthermia-enhanced drug carrier. The pNIPA provided the temperature sensitivity, BISS responsible for degradation in presence of glutathione (GSH) (an –S–S–bond reductor naturally present cells), while...

We have synthesized citric-acid-stabilized magnetic nanoparticles with very good magnetization behavior and relatively low contribution from shape surface anisotropies. In this work, we report also on a simple adsorption of doxorubicin onto the these nanoferrites that can provide facile preparation process for potential drug carriers. To estimate amount adsorbed doxorubicin, propose novel method utilizing ternary system determination interactions between nanoparticles. The Gibbs free...

The exceptional magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) make them promising materials for biomedical applications like hyperthermia, drug targeting and imaging. Easy preparation SPIONs with the controllable, well-defined is a key factor their practical application. In this work, we report simple synthesis Ho-doped by co-precipitation route, controlled size, shape properties. To investigate influence ions ratio on nanoparticles’ properties, multiple...

Iron oxide nanoparticles are commonly used in many medical applications as they can be easily modified, have a high surface-to-volume ratio, and biocompatible biodegradable. This study was performed to synthesize designed for multimodal HER2-positive cancer treatment involving radionuclide therapy magnetic hyperthermia. The core (Fe3O4) coated with gold-198 layer creating so-called core-shell nanoparticles. These were then further modified bifunctional PEG linker monoclonal antibody achieve...

In this work, we present magnetic nanoparticles based on iron oxide doped with zinc synthesized using the wet co-precipitation method for environmental application. The morphology of samples was revealed by SEM and TEM, which showed particles granular shape size about 15 nm. specific surface areas materials BET were within range 85.7 to 101.5 m2 g−1 depending content in superparamagnetic (SPIONs). Magnetometry performed determine properties particles, indicating superparamagnetism....

We present a novel, multicomponent nanoparticulate carrier system based on superparamagnetic iron oxide nanoparticles with designed hydrophilic/hydrophobic balance oleic acid and TWEEN 80 to incorporate hydrophobic cannabinoids—cannabigerol cannabidiol—as well as the hydrophilic anthracycline drug epirubicin, forming conjugate anticancer system. Additionally, oxide-based formed core of system, thus providing it magnetic hyperthermia capabilities specific absorption rate comparable...

Doxorubicin exhibits unusual photoreactivity in aqueous solutions. Our data show that there are two distinct photoreactive pathways for doxorubicin. One is a two-step process leads to the formation of 3-methoxysalicylic acid, stable degradation product. The other pathway photoreduction doxorubicin form corresponding dihydroquinone, which undergoes spontaneous oxidation mediated by dissolved oxygen recover with hydrogen peroxide. account known nonlinear dependence fluorescence intensity on...

To limit cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should be synthesized to deliver the drug tumor tissue only. A good solution is anchor a magnetic nanoparticle molecule and use properly directed external field. The synthesis conjugate doxorubicin with nanoparticles (iron oxide) modified by us resulted in substantial depression aggregation process therefore allowed correct examination drug. It has been shown, performing electrochemical microbalance...

Abstract Studies on magnetoliposomes (MLUV) as potential carriers for magnetic‐field‐dependent drug delivery are presented. The systems were formed with hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) confined within the bilayer of liposomes. nanomechanical properties lipid membranes evaluated and related to amount incorporated SPIONs. It was found that presence SPIONs in membrane leads overall stiffening increases morphological inhomogeneity, facilitating rupture MLUV a...

Magnetoliposomes are promising candidates for the development of selective drug delivery systems in treatment cancer. Those nanosystems were tested as carriers a strong chemotherapeutic agent, doxorubicin, which is used against breast Herein, magnetic properties hydrophobic iron oxide nanoparticles located exclusively lipid bilayer to release this from magnetoliposomes. The cytotoxic activity nanostructures normal and cancer cell lines was determined on basis cells viability measurement...

Iron oxide-based nanoparticles have been modified in their core with holmium(III) an amount affecting only slightly magnetic properties. Nanoparticles were conjugated covalently biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such to specified tumor tissues. Systematic studies Ho3+-doped bioconjugates carried out as a preliminary step for future replacement 'cold' Ho 166Ho radionuclide, emitting 'soft'...