A5085663976- Radiopharmaceutical Chemistry and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Peptidase Inhibition and Analysis
- Crystallography and molecular interactions
- Medical Imaging and Pathology Studies
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Medical Imaging Techniques and Applications
- Orthopaedic implants and arthroplasty
- Monoclonal and Polyclonal Antibodies Research
- Organometallic Complex Synthesis and Catalysis
- Advanced biosensing and bioanalysis techniques
- Radiation Therapy and Dosimetry
- Glycosylation and Glycoproteins Research
- Characterization and Applications of Magnetic Nanoparticles
- Magnetism in coordination complexes
- Nanoparticles: synthesis and applications
- Orthopedic Infections and Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Metalloenzymes and iron-sulfur proteins
- Graphene and Nanomaterials Applications
- Cell Adhesion Molecules Research
- interferon and immune responses
National Centre of Scientific Research "Demokritos"
2013-2024
Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety
2014-2024
Academy of Athens
2014
Institute of Biosciences & Applications
2013
National and Kapodistrian University of Athens
2008
Aristotle University of Thessaloniki
2003-2006
Actinium-225 (225Ac) is receiving increased attention for its application in targeted radionuclide therapy, due to the short range of emitted alpha particles conjunction with their high linear energy transfer, which lead eradication tumor cells while sparing neighboring healthy tissue. The objective our study was evaluation a gold nanoparticle radiolabeled 225Ac as an injectable radiopharmaceutical form brachytherapy local radiation treatment cancer. Au@TADOTAGA at pH 5.6 (30 min 70 °C), and...
The synthesis and characterization of neutral mixed ligand complexes fac-[M(CO)3(P)(OO)] cis-trans-[M(CO)2(P)2(OO)] (M = Re, 99mTc), with deprotonated acetylacetone or curcumin as the OO donor bidentate ligands a phosphine (triphenylphosphine methyldiphenylphosphine) monodentate P ligand, is described. were synthesized through corresponding fac-[M(CO)3(H2O)(OO)] 99mTc) intermediate aqua complex. In presence phosphine, replacement H2O molecule complex at room temperature generates tricarbonyl...
Superparamagnetic iron oxide nanoparticles with well-integrated multimodality imaging properties have generated increasing research interest in the past decade, especially when it comes to targeted of tumors. Bevacizumab (BCZM) on other hand is a well-known and widely applied monoclonal antibody recognizing VEGF-A, which overexpressed angiogenesis. The aim this proof-of-concept study was develop dual-modality nanoplatform for vivo single photon emission tomography (SPET) magnetic resonance...
The aim of this study was to develop a dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging probe by radiolabeling gadolinium-containing AGuIX derivatives with the positron-emitter Gallium-68 (68Ga).AGuIX@NODAGA nanoparticles were labeled 68Ga at high efficiency. Tumor accumulation in an appropriate disease model assessed ex vivo biodistribution and PET/MR imaging. 68Ga-AGuIX@NODAGA proven passively accumulate U87MG human glioblastoma tumor xenografts. Metabolite...
Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10‐tetraazacyclododecane‐1‐glutaric anhydride‐4,7,10‐triacetic acid (DOTAGA)[Gd 3+ ] 2,2'‐(7‐(1‐carboxy‐4‐((2,5‐dioxopyrrolidin‐1‐yl)oxy)‐4‐oxobutyl)‐1,4,7‐triazonane‐1,4‐diyl)diacetic acid) NODAGA[ 68 Ga have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature ligands available radiolabelling quantify them. High...
The aim of this study was to develop a dual-modality PET/MR imaging probe by radiolabeling iron oxide magnetic nanoparticles (IONPs), surface functionalized with water soluble stabilizer 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD), the positron emitter Gallium-68. Magnetite (Fe 3 O 4 MNPs) were synthesized via coprecipitation method and stabilized DPD. Fe -DPD MNPs characterized based on their structure, morphology, size, charge, properties. In vitro cytotoxicity studies showed reduced...
Purpose: To evaluate the antitumor efficacy of Ag 3 Au 1 Trp 1:2 NPs in a SCID mouse cancer model, with respect to their effect on tumor growth, tumor's metastatic potential and underlying molecular mechanism. Subjects Methods: were radiolabeled Gallium-68 biodistribution was studied Swiss mice without tumors bearing tumors. received intratumoral size measured using calipers. Lung liver tissues extracted microscopically for detection any sites. Changes Caspase-3 TNF-related...
Theranostic radioisotope pairs such as Gallium-68 (68Ga) for Positron Emission Tomography (PET) and Lutetium-177 (177Lu) radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field the treatment of cancer. The present work aims to demonstrate ability condensed colloidal nanocrystal clusters (co-CNCs) comprised iron oxide nanoparticles, coated alginic acid (MA) stabilized by a layer polyethylene glycol (MAPEG) be directly radiolabeled 68Ga its therapeutic analog...
The aim of this study was to develop a bioimaging probe based on magnetic iron oxide nanoparticles (MIONs) surface functionalized with the copolymer (p(MAA-g-EGMA)), which were radiolabeled positron emitter Gallium-68. synthesis hybrid MIONs realized by hydrolytic condensation single ferrous precursor in presence copolymer. synthesized MagP displayed an average Dh 87 nm, suitable for passive targeting cancerous tissues through enhanced permeation and retention (EPR) effect after intravenous...
The synthesis and characterization of three neutral tricarbonyl fac-M(CO)3(NNO) (M = Re, 99mTc) complexes based on the picolylamine N,N-diacetic acid (PADA) ligand is reported. One two carboxylate groups PADA efficiently conveniently derivatized with an amine nucleophile through use anhydride. In this work, aniline, benzylamine pyrrolidine were used as model nucleophiles. rhenium synthesized using [NEt4]2[Re(CO)3Br3] precursor fully characterized by elemental analysis, spectroscopic methods,...
During recent years, a plethora of pioneering radiolabeled nanoparticles have grown to be an integral part nuclear medicine as theranostic tools. Herein, we focus on the most representative examples past decade, which been investigated in conjunction with radioisotopes aiming serve drug delivery or imaging agents. The present review highlights key attributes each nanosystem and following classification nanovehicles is based increasing mass number (A) radioisotopic elements.
Radiolabeled gold nanoparticles (AuNPs) have been widely used for cancer diagnosis and therapy over recent decades. In this study, we focused on the development in vitro evaluation of four new Au nanoconjugates radiolabeled with technetium-99m (99mTc) via thiol-bearing ligands attached to NP surface. More specifically, AuNPs two different sizes (2 nm 20 nm, referred as Au(2) Au(20), respectively) were functionalized bifunctional thiol (referred L1H L2H). The shape, size, morphology both bare...
The synthesis and characterization of oxotechnetium oxorhenium mixed-ligand complexes the general formula MO[NN][S]3 (M = 99Tc Re), where NN represents bidentate ligand 2,2'-bipyridine S a monodentate thiophenol, is reported. were prepared by exchange reactions using 99Tc-gluconate ReOCl3(PPh3)2 as precursors for complexes, respectively. Compound 1 99Tc, 4-methylthiophenol) crystallizes in monoclinic space group P21/a, 23.12(1) Å, b 14.349(6) c 8.801(4) β 94.81(2)°, V 2918(2) Å3, Z 4. 3 Re,...