A5022271282- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Characterization and Applications of Magnetic Nanoparticles
- Radiation Therapy and Dosimetry
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Medical Imaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Medical Imaging and Pathology Studies
- Bone health and treatments
- Porphyrin Metabolism and Disorders
- Advanced Radiotherapy Techniques
- Atomic and Subatomic Physics Research
- Metabolism and Genetic Disorders
- Electrochemical Analysis and Applications
- Vanadium and Halogenation Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Cancer therapeutics and mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Radioactive element chemistry and processing
- Free Radicals and Antioxidants
- Chemical Synthesis and Characterization
- Phytase and its Applications
- Erythrocyte Function and Pathophysiology
- Enzyme Structure and Function
University of Belgrade
2016-2025
A. N. Nesmeyanov Institute of Organoelement Compounds
2023
Instituto Murciano de Investigación Biosanitaria
2023
Forschungs- und Beratungsstelle Arbeitswelt
2023
Vinča Institute of Nuclear Sciences
2014-2021
Vienna Institute for Nature Conservation & Analyses
2021
Japan Radioisotope Association
2017
Development of a complex based on iron oxide nanoparticles (IONPs) for diagnosis and dual magnetic hyperthermia/radionuclide cancer therapy accomplishing high yields radiolabeling great heat induction is still challenge. We report here the synthesis citric acid, poly(acrylic acid) (PAA) poly(ethylene glycol) coated IONPs their labeling with three radionuclides, namely, technetium (99mTc), yttrium (90Y), lutetium (177Lu), aiming at potential use in therapy. Polyol-synthesized are flowerlike...
Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe3O4-Naked (80 ± 5 nm) and polyethylene glycol 600 diacid functionalized Fe3O4 (Fe3O4-PEG600) MNPs (46 0.6 nm). They characterized based on the external morphology, size distribution, colloidal properties. The obtained specific power absorption value for Fe3O4-PEG600 was 200 W/g, indicated potential hyperthermia cancer treatments. labeling yield, vitro stability...
The aim of this study was to develop a dual-modality PET/MR imaging probe by radiolabeling iron oxide magnetic nanoparticles (IONPs), surface functionalized with water soluble stabilizer 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD), the positron emitter Gallium-68. Magnetite (Fe 3 O 4 MNPs) were synthesized via coprecipitation method and stabilized DPD. Fe -DPD MNPs characterized based on their structure, morphology, size, charge, properties. In vitro cytotoxicity studies showed reduced...
Radiolabeled albumin microspheres with encapsulated citric acid-coated magnetite nanoparticles were developed as a targeting approach to localize both radioactivity and magnetic energy at the tumor site. We present in vitro vivo studies of yttrium-90 (90Y)-labeled human serum (HSAMMS) multifunctional agent for possible applications bimodal radionuclide-hyperthermia cancer therapy. The HSAMMS produced using modified emulsification-heat stabilization technique contained 11 nm coated acid,...
Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated nontoxic to CT-26 mouse colon cells up 1.0 mg ml-1in vitro. In oscillating magnetic field, citrate-coated (CA/SPIONs) displayed highest rate (SAR ∼ 253 W g-1)...
Radiolabeled magnetic nanoparticles (MNPs) coated with hydrophilic phosphate ligands, i.e., imidodiphosphate (IDP) and inositol hexaphosphate (IHP), were developed as multifunctional agents to localize both radioactivity energy at a tumor site. The coating of MNPs phosphates made them biocompatible, increased their colloidal stability allowed binding the radionuclide 90Y available functional groups on surface MNPs. IDP IHP have not hitherto been used for results this study functionalized...
As an alternative to classical brachytherapy, intratumoral injection of radionuclide-labeled nanoparticles (nanobrachytherapy, NBT) has been investigated as a superior delivery method over intravenous route for radionuclide therapy solid tumors. We created superparamagnetic iron oxide (SPIONs) coated with meso-1,2-dimercaptosuccinic acid (DMSA) and radiolabeled Lutetium-177 (177Lu), generating 177Lu-DMSA@SPIONs potential antitumor agent nanobrachytherapy. Efficient radiolabeling DMSA@SPIONS...
Two novel diamine dioxime ligands, 4,7‐diaza‐3,8‐diethyldecane‐2,9‐dione bis oxime (3) and 4,9‐diaza‐3,10‐diethyldodecane‐2,11‐dione (5), were synthesized in order to develop new brain perfusion imaging agents, based on 99m Tc(V)‐complexes. The synthesis involved condensation of 2‐hydroxyimino‐3‐pentanone with appropriate protic solvent which afforded the imine adducts. Subsequent reduction functional groups yielded a diastereoisomeric mixture 3 5. UV–visible, IR, 1 H NMR, 13 C NMR elemental...
Application of bone-seeking radiopharmaceuticals is one the modalities in management metastatic bone pain. The present study aimed to investigate potential 177Lu-labeled phosphate/phosphonate ligands: 1-hydroxyethane 1,1-diphosphonic acid (HEDP), 2,3-dicarboxypropane-1,1-diphosphonic (DPD), and imidodiphosphate tetrasodium salt (IDP), as pain palliation agents. HEDP, DPD, IDP were radiolabeled with 177Lu high radiolabeling yield (98.49%, 93.31%, 90.69%, respectively), forming vitro stable...
The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment.
Two new Schiff base cobalt(III) ([Co(LH)Cl2], 1) and nickel(II) ([Ni(LH)ClO4], 2) complexes with a diimine-dioxime ligand, (4,9-diaza-3,10-diethyl-3,9-dodecadiene-2,11-dione bis oxime (LH2)), were synthesized characterized. The compounds obtained in MeOH from corresponding metal salts LH2 molar ratio 1:1 further characterized by mass spectrometry, IR spectroscopy, electrochemistry, elemental analysis. Previously reported copper(II) analog ([Cu2(LH)2]·(ClO4)2, 3) was joined to 1 2, the three...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
The environmental impact of radionuclides, found in nuclear waste, power plants, agriculture, industrial effluents, research centers, and medicine facilities, is highly important, especially the emerging era. Prior to its stabilization permanent disposal, development appropriate techniques for radionuclide removal from environment a critical topic. Particular attention given materials that are easy synthesize, manipulate, demonstrate high pollutant efficiency. Among different yttrium...
In this work there was investigated the influence of selenium and deodinases blockers on juvenile rats body weight during three months. The experiment carried out 64 divided into eight groups with individual animals per group. Following were formed: 1. Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU- IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- 8. Se-PTU-IA+. labeled (Se+) adequate they fed food that contained 0.334 mg Se/kg. (Se-) deficient obtained 0.031 As...